Late-onset chronic mucocutaneous and ocular candidiasis and malignant thymoma

Abstract

Late-onset chronic mucocutaneous candidiasis (CMCC) is part of a spectrum of candidal infections. It usually develops during or after the fourth decade of life and is often associated with an underlying neoplasm, especially thymoma. A 56-year-old man with late-onset CMCC and thymoma had several unusual features. His malignant thymoma seemed to be more widespread than the thymomas of previously described patients. Ocular infection was present in addition to extensive involvement of the skin, nails, and oral mucosa. To our knowledge, this is the first report of ocular involvement in this syndrome. We also believe that this is the first patient with thymoma-associated late-onset CMCC to be treated effectively with ketoconazole.

Protection by Candida albicans of Staphylococcus aureus in the establishment of dual infection in mice

“…In clinical candidiasis, Candida albicans is frequently found with Staphylococcus aureus and Streptococcus species (2,7,10,11,(14)(15)(16)(17)(18)(19)(20)23). In addition, S. aureus has been found to be a frequent opportunist in experimentally induced candidiasis (19).…”

Co‐existent cutaneous cryptococcosis of the forearm and cutaneous alternariosis of the leg in patient with metastatic thymoma

“…Among these infections, cutaneous mycoses are unusual and implicated agents are essentially candidiasis and dermatophytosis 23 . Only “late onset chronic mucocutaneous candidiasis” is recognized to be a characteristic association with thymoma 24 . Our case study highlights that patients with iatrogenic and endogenous causes of immunosuppression, particularly long‐term corticosteroid therapy and CD4 + lymphopenia, may develop extensive primary cutaneous rare mycosis.…”

A case of mixed connective tissue disease complicated with thymic carcinoma and Hashimoto's thyroiditis

“…26 Miscellaneous disease include hypertrophic osteoarthropathy, 27 nephrotic syndrome, 28 minimal change nephropathy, 29 pemphigus, 30 and chronic mucocutaneous candidiasis. 31 Primary thymic carcinoma is a rare neoplasm. At the National Cancer Center of Tokyo, 17 cases were resected over a 29-year period, during which time 79 thymomas and 2500 lung cancers were treated.…”