Late onset acute pancreatitis in P. falciparum malaria – An adverse reaction to intravenous artesunate?

Mahdi, Asmaa S.; Molai, Mariya; Chandwani, Juhi; Khalili, Huda Al; Ibrahim, Hashim; Pandak, Nenad; Khamis, Faryal; Petersen, Eskild

doi:10.1016/j.idcr.2018.04.010

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…transmitted by female Anopheles mosquitoes [ 24 ]. Although malaria is life-threatening, early diagnosis and appropriate treatment lead to it having an excellent prognosis [ 25 ]. Global data show that around 229 million people are affected by malaria, while about 409,000 succumb to it annually; hence, efforts are needed to prevent and control it [ 26 ].…”

Section: Malaria and Its Parasite Life Cyclementioning

confidence: 99%

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Recent Advances in the Therapeutic Efficacy of Artesunate

2022

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Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line drug for treating malaria. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses. It also exhibits antidiabetic, anti-inflammatory, anti-atherosclerosis, immunosuppressive activities, etc. During its administration, artesunate can be loaded in liposomes, alone or in combination with other therapeutic agents. Administration routes include intragastrical, intravenous, oral, and parenteral. The biological activity of artesunate is based on its ability to regulate some biological pathways. This manuscript reports a critical review of the recent advances in the therapeutic efficacy of artesunate.

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Section: Malaria and Its Parasite Life Cyclementioning

confidence: 99%

“…The pancreatitis was seen as a possible adverse reaction to intravenous ART [ 43 ] after using the adverse drug reaction probability score. Intravenous fluid and pain management led to a rapid response of pancreatitis, and it did not reoccur even up to 2 months post-treatment [ 25 ].…”

Section: Malaria and Its Parasite Life Cyclementioning

confidence: 99%