Late-onset acute graft-versus-host disease mimicking hand, foot, and mouth disease

Abstract

Acute skin graft-versus-host disease (GVHD) classically presents as a pruritic erythematous maculopapular rash. We describe a patient who underwent allogeneic hematopoietic stem cell transplantation and presented with a hand foot and mouth disease like clinical presentation. Histopathology was suggestive of acute GVHD. This case is being reported to make dermatologists aware of this unusual presentation of GVHD.

Graft versus host disease localized to striae distensae: An example of locus minoris resistentiae

“…Though graft versus host disease is a systemic affliction, the skin is affected preferentially; in both acute and chronic forms. Atypical cutaneous variants have been previously described [Table 1] [15][16][17][18] highlighting the effect of the microenvironmental and constitutional factors on the final presentation of the Graft-versus-host disease represents one of the most common complications of allogeneic hematopoietic stem cell transplantation. 1 Its classification was previously based on the time point of 100 days (acute 100 days); though this was later revised to include cases of acute graft versus host disease that occurred beyond this time-point (persistent, recurrent and de-novo).…”