Late new morbidity in survivors of adolescent and young-adulthood brain tumors in Finland: a registry-based study

Gunn, Mirja Erika; Malila, Nea; Lähdesmäki, Tuire; Arola, Mikko; Grönroos, M; Matomäki, Jaakko; Lähteenmäki, Päivi

doi:10.1093/neuonc/nov115

Cited by 20 publications

(22 citation statements)

References 29 publications

(49 reference statements)

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“…In contrast, the majority of patients with CNS cancer receive cranial radiotherapy, which increases the risk of late endocrine and cerebrovascular morbidities and subsequent neoplasms. [23][24][25] Patients with lymphoma who receive anthracycline-based chemotherapy and/or mediastinal radiotherapy are at an increased risk of late cardiac morbidity. 26 Survivors of breast cancer also are likely to undergo chest wall radiotherapy and/or receive anthracycline-based chemotherapy and thus have an increased risk of late cardiac morbidity.…”

Section: Discussionmentioning

confidence: 99%

Long‐term survival among 5‐year survivors of adolescent and young adult cancer

Berkman

Livingston

Merriman

et al. 2020

Cancer

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BACKGROUND: Although there are a growing number of survivors of adolescent and young adult (AYA) cancer, to the authors' knowledge the long-term overall survival (OS) patterns for AYA cancer survivors are underreported. The objective of the current study was to assess the long-term survival of AYA cancer survivors and identify factors associated with diminished long-term survival. METHODS: The authors used The University of Texas MD Anderson Cancer Center's tumor registry to identify 5-year survivors of cancer diagnosed as AYAs (ages 15-39 years) between the years 1970 and 2005, and who were alive 5 years after diagnosis. Kaplan-Meier curves were used to estimate OS rates over time, and Cox proportional hazards models were fitted to evaluate the association of covariates with OS. RESULTS: The authors identified 16,728 individuals who were 5-year survivors of cancer and were diagnosed as AYAs with a median follow-up of 20.0 years. The 10-year, 20-year, and 25-year OS rates were 86% (95% confidence interval [95% CI], 85%-86%), 74% (95% CI, 73%-75%), and 68% (95% CI, 67%-68%), respectively, all of which were lower than the age-adjusted estimated survival rates of the general population. Long-term OS improved for AYAs diagnosed between 2000 and 2005 compared with those diagnosed in the prior decades (P < .001). Older age at the time of diagnosis, receipt of radiation, and diagnoses including central nervous system tumors and breast cancer each were associated with diminished long-term survival. CONCLUSIONS: AYA cancer survivors have inferior long-term survival compared with the general population. Studies investigating the prevalence and types of late treatment effects and causes of death among AYA survivors are needed to more accurately identify AYAs who are at highest risk of early or late mortality.

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Section: Discussionmentioning

confidence: 99%

Long‐term survival among 5‐year survivors of adolescent and young adult cancer

Berkman

Livingston

Merriman

et al. 2020

Cancer

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“…In long-term morbidity research in CCS, a broad variety of outcome assessment methods is used. Long-term morbidity outcomes can be assessed by self-reporting via questionnaires [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], by medical evaluation during outpatient clinic visits [25][26][27][28][29][30][31][32][33][34] or by linkage with existing registries such as national hospital discharge registries [35][36][37][38][39]. Authors often include different types and different numbers of organ systems in their calculations of physical long-term morbidity .…”

Section: Introductionmentioning

confidence: 99%

“…Also, incidence or prevalence estimates are often reported without describing which health conditions or organ systems were included in these calculations. Definitions of long-term morbidity outcomes also vary, for example, authors reporting on cardiovascular conditions generally report on heart failure, myocardial infarction, and hypertension, but some also include stroke as a cardiovascular condition [ 10 , 14 , 17 , 18 , 36 ]. While many authors do not grade the severity of the reported long-term morbidity in CCS, others use the Common Terminology Criteria for Adverse Events (CTCAE) [ 40 ], either in its original form or an adapted version incorporating specific additional outcomes that authors considered missing [ 41 – 43 ].…”

Section: Introductionmentioning

confidence: 99%

The Dutch LATER physical outcomes set for self-reported data in survivors of childhood cancer

et al. 2020

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Purposes Studies investigating self-reported long-term morbidity in childhood cancer survivors (CCS) are using heterogeneous outcome definitions, which compromises comparability and include (un)treated asymptomatic and symptomatic outcomes. We generated a Dutch LATER core set of clinically relevant physical outcomes, based on self-reported data. Clinically relevant outcomes were defined as outcomes associated with clinical symptoms or requiring medical treatment. Methods First, we generated a draft outcome set based on existing questionnaires embedded in the Childhood Cancer Survivor Study, British Childhood Cancer Survivor Study, and Dutch LATER study. We added specific outcomes reported by survivors in the Dutch LATER questionnaire. Second, we selected a list of clinical relevant outcomes by agreement among a Dutch LATER experts team. Third, we compared the proposed clinically relevant outcomes to the severity grading of the Common Terminology Criteria for Adverse Events (CTCAE). Results A core set of 74 self-reported long-term clinically relevant physical morbidity outcomes was established. Comparison to the CTCAE showed that 36% of these clinically relevant outcomes were missing in the CTCAE. Implications for Cancer Survivors This proposed core outcome set of clinical relevant outcomes for self-reported data will be used to investigate the self-reported morbidity in the Dutch LATER study. Furthermore, this Dutch LATER outcome set can be used as a starting point for international harmonization for long-term outcomes in survivors of childhood cancer.

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“…Survivors of CNS tumors are at risk for long-term adverse neurologic sequelae from the tumor and its treatment. [1][2][3][4][5][6] As survivors of CNS tumors age, there is a need to better understand the incidence of and risk factors for lateonset adverse neurologic sequelae and how risks for these adverse events may change over time.…”

mentioning

confidence: 99%

Longitudinal assessment of late-onset neurologic conditions in survivors of childhood central nervous system tumors: a Childhood Cancer Survivor Study report

et al. 2017

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Late new morbidity in survivors of adolescent and young-adulthood brain tumors in Finland: a registry-based study

Abstract: The AYA BT survivors have an increased risk of morbidity for multiple new outcomes for ≥5 years after their primary diagnosis. This emphasizes the need for structured late-effect follow-up for this patient group.

Cited by 20 publications

References 29 publications

Long‐term survival among 5‐year survivors of adolescent and young adult cancer

Long‐term survival among 5‐year survivors of adolescent and young adult cancer

The Dutch LATER physical outcomes set for self-reported data in survivors of childhood cancer

Longitudinal assessment of late-onset neurologic conditions in survivors of childhood central nervous system tumors: a Childhood Cancer Survivor Study report

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