Late Metastasis of Renal Cell Carcinoma in Distal Femur Treated with Knee Joint Preservation: A Case Report

Metastatic Clear Cell Renal Cell Carcinoma Presenting as Acute Appendicitis

“…Remarkably, the metastasis was identified more than five years following a nephrectomy for RCC, highlighting the need for awareness of this rare metastatic site and potential long-term recurrence. RCC metastasis to other sites following many years (decades) after being successfully treated with surgery was documented by some other authors [5][6][7][8]. These cases, including ours, underscore that RCC patients cannot be considered fully cured even after successful resection and suggest a possible reconsideration of surveillance periods and practices.…”

A case report of renal cell carcinoma metastasis revealed through late‐onset thyroid nodules

“…Late metastasis cases, including those with disease-free survival exceeding 10 years, have been reported. 19,20 The concept of temporary mitotic arrest or cellular dormancy may partially explain the occurrence of overt metastasis or recurrence many years after successful treatment of the primary tumor. Aging-related decline in immune function may influence host-tumor interaction, promoting the proliferation of dormant malignant cells in various tissues.…”

“…Our patient encountered this complication 13 years after the initial successful therapy. Late metastasis cases, including those with disease‐free survival exceeding 10 years, have been reported 19,20 …”

“…Late metastasis cases, including those with disease‐free survival exceeding 10 years, have been reported. 19 , 20 …”