Late HCC onset after direct antiviral agents therapy in patients with sustained virological response: do we need to reconsider their efficacy according to long term follow-up?

Perrella, Alessandro; Izzi, Antonio; Punzi, Rodolfo; Adinolfi, Elena; Sbreglia, Costanza; Bellopede, Pasquale; Lanza, A; Martucci, Fiorella; Rinaldi, Luca

doi:10.1080/00365521.2018.1495260

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…HCC treatment includes mainly surgical resection, radiofrequency ablation, interventional therapy, and liver transplantation, of which surgical resection is the most commonly used [4,5]. However, because systemic chemotherapy drugs for HCC are ineffective, 70% of patients still have recurrence and metastasis 5 years after surgery [6,7]. Currently, the pathogenesis of HCC remains unclear, so finding a definitive and effective treatment is difficult [8].…”

Section: Introductionmentioning

confidence: 99%

Transmembrane and Ubiquitin-Like Domain Containing 1 Protein (TMUB1) Negatively Regulates Hepatocellular Carcinoma Proliferation via Regulating Signal Transducer and Activator of Transcription 1 (STAT1)

Chen

Zhang

et al. 2019

Med Sci Monit

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Background: Hepatocellular carcinoma (HCC) is a common malignancy, but the pathogenesis of HCC is unclear. TMUB1 has an inhibitory effect on normal hepatocytes, but its role in HCC has not been reported. Material/Methods: We used immunohistochemistry to observe the expression of transmembrane and ubiquitin-like domain containing 1 protein (TMUB1) and signal transducer and activator of transcription 1 (STAT1) in 132 HCC tissue specimens. The expression of TMUB1, STAT1, and CCND1 in HCC cells were detected by quantitative polymerase chain reaction (qPCR) and western blotting. Cell Counting Kit-8 (CCK-8) and 5-ethynyl-2'-deoxyuridine (EdU) assays were used for detecting HCC cells proliferation, and Transwell assays were used for observing the invasion and migration of HCC cells. Results: TMUB1 was negatively correlated with HCC pathological malignancy; low expression of TMUB1 indicated poor prognosis. TMUB1 inhibited proliferation but not metastasis in HCC cells. TMUB1 expression was positively correlated with STAT1 in 132 HCC tissues, TMUB1 promoted the expression of STAT1, and suppressed the expression of CCND1 in HCC cells. Conclusions: TMUB1 negatively regulates hepatocellular carcinoma proliferation via regulating STAT1.

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Section: Introductionmentioning

confidence: 99%

Transmembrane and Ubiquitin-Like Domain Containing 1 Protein (TMUB1) Negatively Regulates Hepatocellular Carcinoma Proliferation via Regulating Signal Transducer and Activator of Transcription 1 (STAT1)

Chen

Zhang

et al. 2019

Med Sci Monit

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Role of Liver Stiffness Measurement in Predicting HCC Occurrence in Direct-Acting Antivirals Setting: A Real-Life Experience

et al. 2019

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Oxaliplatin (OXA)-Loaded Nanoparticles Inhibit the Proliferation and Migration of Hepatocellular Carcinoma Cells

Yuan,

Zhou,

Yan

et al. 2024

j biomed nanotechnol

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Our study proposed to explore the impact of OXA-loaded nanoparticles on hepatocellular carcinoma (HCC) cell proliferation and migration. The nanoparticles (OXA@ cRGD-TAT-PLGA) were successfully established after optimizing the preparation method. The nanoparticle size was approximately 500 nm under the scanning electron microscope. The nanoparticles were stable with regular spheres. The loading content (LC) of OXA-loaded PLGA nanoparticles was 3.5%. The encapsulation efficiency (EE) was 61.5% with stable release processing. This was an ideal sustained-release material. The average particle size of four nanoparticles was approximately 200–300 nm with negative charges. The proliferation of HCC cells treated with blank nanoparticles was not significantly affected, indicating that blank nanoparticles showed no cytotoxicity, whereas OXA@PLGA-TAT-cRGD significantly promoted apoptosis and inhibited the migration and proliferation of HepG2 cells. The drug delivery vector modified with cRGD peptide constructs effectively delivered drugs into HCC cells. OXA@PLGA-TAT-cRGD showed promising effects on the promotion of apoptosis and inhibition of migration in HCC cells, thereby making it an ideal drug delivery material.

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Late HCC onset after direct antiviral agents therapy in patients with sustained virological response: do we need to reconsider their efficacy according to long term follow-up?

Cited by 3 publications

References 4 publications

Transmembrane and Ubiquitin-Like Domain Containing 1 Protein (TMUB1) Negatively Regulates Hepatocellular Carcinoma Proliferation via Regulating Signal Transducer and Activator of Transcription 1 (STAT1)

Transmembrane and Ubiquitin-Like Domain Containing 1 Protein (TMUB1) Negatively Regulates Hepatocellular Carcinoma Proliferation via Regulating Signal Transducer and Activator of Transcription 1 (STAT1)

Role of Liver Stiffness Measurement in Predicting HCC Occurrence in Direct-Acting Antivirals Setting: A Real-Life Experience

Oxaliplatin (OXA)-Loaded Nanoparticles Inhibit the Proliferation and Migration of Hepatocellular Carcinoma Cells

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