Late Haemorrhagic Disease in Sweden 1987–89

Ekelund, H

doi:10.1111/j.1651-2227.1991.tb11763.x

Cited by 57 publications

(38 citation statements)

References 7 publications

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“…The main cause or causes of the vitamin K deficiency remain unknown, but breast-feeding probably played an important role. To prevent the appearence of late HDN, some authors have proposed that vitamin K prophylaxis at birth should be followed by further doses of oral vitamin K during the first months of life, not only for high-risk patients but also for healthy newborns [2]. Our case and another previously reported case support this proposal [9].…”

Section: Discussionsupporting

confidence: 87%

Late hemorrhagic disease of the newborn as a cause of intracerebral bleeding

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Ginovart

et al. 1997

Annals of Hematology

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We report a case of a 4-week-old female who presented with late hemorrhagic disease of the newborn (HDN). The newborn was previously healthy, and she received 1 mg of intramuscular vitamin K at birth. She was exclusively breast-fed. At 4 weeks she began bleeding at the umbilicus and 4 days after she suffered an intracranial hemorrhage. Coagulation studies showed a deficiency of vitamin K-dependent coagulation factors, and the normalization of all clotting studies after administration of vitamin K confirmed the diagnosis of HDN. Our conclusions are that physicians must be alert to mild bleeding in newborns and that prophylaxis with 1 mg of intramuscular vitamin K at birth may be insufficient to prevent late HDN.

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Section: Discussionsupporting

confidence: 87%

Late hemorrhagic disease of the newborn as a cause of intracerebral bleeding

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Ginovart

et al. 1997

Annals of Hematology

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“…There are a number of likely reasons for this. Intramuscular administration of 1 mg of vitamin K 1 after delivery oers great protection from VKDB [6]. However, because of the invasiveness and associated risks, the acceptance of this form of prophylaxis has decreased in many places [3,12,13].…”

Section: Discussionmentioning

confidence: 99%

Oral vitamin K 1 prophylaxis for newborns with a new mixed-micellar preparation of phylloquinone: 3 years experience in Switzerland

Schubiger

Stocker

Bänziger

et al. 1999

European Journal of Pediatrics

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With the introduction of two oral doses of a mixed-micellar vitamin K1 preparation administered in the 1st week of life, the incidence of late vitamin K1-deficiency-bleeding has decreased from 7.2:100,000 between 1986-1987 to 2.8:100,000 between 1995 and 1998. This regimen may be suitable for prophylaxis of vitamin K1-deficiency-bleeding, however, it does not fully protect infants with cholestatic disease from late-onset bleeding. If oral prophylaxis is considered for these infants, vitamin K1 has to be administered repeatedly to all infants during the breast feeding period.

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“…In countries where PO administration was the primary form of prophylaxis, the incidence of late VKDB varied: from 1.6 per 100,000 infants (in the UK), 1.9 ( Japan), 5.1 (Sweden) to 6.4 (Switzerland) (19)(20)(21)(22). Some of these infants may also have had underlying disorders that affected vitamin K metabolism (23).…”

Section: Prevention Of Late Vkdbmentioning

confidence: 99%

Guidelines for vitamin K prophylaxis in newborns

Loewy

2018

Paediatrics &Amp; Child Health

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A joint statement with the College of Family Physicians of CanadaAll Canadian Paediatric Society position statements and practice points are reviewed regularly and revised as needed. Consult the Position Statements section of the CPS website www.cps.ca/en/documents for the most current version. Retired statements are removed from the website. AbstractNewborns are at risk for vitamin K deficiency bleeding (VKDB) caused by inadequate prenatal storage and deficiency of vitamin K in breast milk. Systematic review of evidence to date suggests that a single intramuscular (IM) injection of vitamin K at birth effectively prevents VKDB. Current scientific data suggest that single or repeated doses of oral (PO) vitamin K are less effective than IM vitamin K in preventing VKDB. The Canadian Paediatric Society and the College of Family Physicians of Canada recommend routine IM administration of a single dose vitamin K at 0.5 mg to 1.0 mg to all newborns. Administering PO vitamin K (2.0 mg at birth, repeated at 2 to 4 and 6 to 8 weeks of age), should be confined to newborns whose parents decline IM vitamin K. Health care providers should clarify with parents that newborns are at increased risk of VKDB if such a regimen is chosen. Current evidence is insufficient to recommend routine intravenous vitamin K administration to preterm infants undergoing intensive care.

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Late Haemorrhagic Disease in Sweden 1987–89

Cited by 57 publications

References 7 publications

Late hemorrhagic disease of the newborn as a cause of intracerebral bleeding

Late hemorrhagic disease of the newborn as a cause of intracerebral bleeding

Oral vitamin K 1 prophylaxis for newborns with a new mixed-micellar preparation of phylloquinone: 3 years experience in Switzerland

Guidelines for vitamin K prophylaxis in newborns

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