Late Genitourinary Toxicity Outcomes in 300 Prostate Cancer Patients Treated With Dose-escalated Image-guided Intensity-modulated Radiotherapy

Byrne, Keelan; Hruby, George; Kneebone, Andrew; Whalley, Deborah; Guo, Linxin; McCloud, Philip; Eade, Thomas

doi:10.1016/j.clon.2017.03.006

Cited by 16 publications

(18 citation statements)

References 43 publications

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“…In this study, previous TURP was significantly associated with grade 2 late GU toxicity. A study of IMRT demonstrated that previous TURP was associated with late GU toxicity [37]. Another study of IMRT, DM was reported as a predictive factor for late grade 2 or greater GU toxicities [38].…”

Section: Discussionmentioning

confidence: 99%

Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer

et al. 2020

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Background: Carbon-ion radiotherapy (CIRT) for prostate cancer was initiated at Kanagawa Cancer Center in 2015. The present study analyzed the preliminary clinical outcomes of CIRT for prostate cancer. Methods: The clinical outcomes of 253 patients with prostate cancer who were treated with CIRT delivered using the spot scanning method between December 2015 and December 2017 were retrospectively analyzed. The irradiation dose was set at 51.6 Gy (relative biological effectiveness) delivered in 12 fractions over 3 weeks. Biochemical relapse was defined using the Phoenix definition. Toxicities were assessed according to CTCAE version 4.0. Results: The median patient age was 70 (47-86) years. The median follow-up duration was 35.3 (4.1-52.9) months. According to the D'Amico classification system, 8, 88, and 157 patients were classified as having low, intermediate, and high risks, respectively. Androgen deprivation therapy was administered in 244 patients. The biochemical relapse-free rate in the low-, intermediate-, and high-risk groups at 3 years was 87.5, 88.0, and 97.5%, respectively (P = 0.036). Grade 2 acute urinary toxicity was observed in 12 (4.7%) patients. Grade 2 acute rectal toxicity was not observed. Grade 2 late urinary toxicity and grade 2 late rectal toxicity were observed in 17 (6.7%) and 3 patients (1.2%), respectively. Previous transurethral resection of the prostate was significantly associated with late grade 2 toxicity in univariate analysis. The predictive factor for late rectal toxicity was not detected. Conclusion: The present study demonstrated that CIRT using the spot scanning method for prostate cancer produces favorable outcomes.

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Section: Discussionmentioning

confidence: 99%

Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer

et al. 2020

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show abstract

“…In this study, TURP was significantly associated with grade 2 late GU toxicity. In a study of IMRT demonstrated that previous TURP was associated with late GU toxicity [35]. Other study of IMRT, DM was reported as a predictive factor for late Grade 2 or greater GU toxicities [36].…”

Section: Discussionmentioning

confidence: 99%

Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer

Takakusagi

Kato²,

Kano

et al. 2020

Preprint

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Background Carbon-ion radiotherapy (CIRT) for prostate cancer was initiated at Kanagawa Cancer Center in 2015. The present study analyzed the preliminary clinical outcomes of CIRT for prostate cancer. Methods The clinical outcomes of 253 patients with prostate cancer who were treated with CIRT delivered using the spot scanning method between December 2015 and December 2017 were retrospectively analyzed. The irradiation dose was set at 51.6 Gy (relative biological effectiveness) delivered in 12 fractions over 3 weeks. Biochemical relapse was defined using the Phoenix definition. Toxicities were assessed according to CTCAE version 4.0. Results The median patient age was 70 (47–86) years. The median follow-up duration was 35.3 (4.1–52.9) months. According to the D’Amico classification system, 8, 88, and 157 patients were classified as having low, intermediate, and high risks, respectively. Androgen deprivation therapy was administered in 244 patients. The biochemical relapse-free rate in the low-, intermediate-, and high-risk groups at 3 years was 87.5%, 88.0%, and 97.5%, respectively (P = 0.036). Grade 2 acute urinary toxicity was observed in 12 (4.7%) patients. Grade 2 acute rectal toxicity was not observed. Grade 2 late urinary toxicity and grade 2 late rectal toxicity were observed in 17 (6.7%) and three patients (1.2%), respectively. Diabetes mellitus and previous transurethral resection of the prostate were significantly associated with late grade 2 toxicity in univariate analysis. The predictive factor for late rectal toxicity was not detected. Conclusion The present study demonstrated that CIRT using the spot scanning method for prostate cancer produces favorable outcomes.

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“…In this study, previous TURP was signi cantly associated with grade 2 late GU toxicity. A study of IMRT demonstrated that previous TURP was associated with late GU toxicity [37]. Another study of IMRT, DM was reported as a predictive factor for late grade 2 or greater GU toxicities [38].…”

Section: Discussionmentioning

confidence: 99%

“…The present study had several limitations such as its single-institutional nature and short observation period. More than 80% of late toxicities occurred within 2 years after CIRT [37]; therefore, toxicities were evaluated for a su cient period in the present study. Further observation with a large patient cohort will be necessary to con rm our clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer

Takakusagi

Kato²,

Kano

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Carbon-ion radiotherapy (CIRT) for prostate cancer was initiated at Kanagawa Cancer Center in 2015. The present study analyzed the preliminary clinical outcomes of CIRT for prostate cancer. Methods: The clinical outcomes of 253 patients with prostate cancer who were treated with CIRT delivered using the spot scanning method between December 2015 and December 2017 were retrospectively analyzed. The irradiation dose was set at 51.6 Gy (relative biological effectiveness) delivered in 12 fractions over 3 weeks. Biochemical relapse was defined using the Phoenix definition. Toxicities were assessed according to CTCAE version 4.0. Results: The median patient age was 70 (47–86) years. The median follow-up duration was 35.3 (4.1–52.9) months. According to the D’Amico classification system, 8, 88, and 157 patients were classified as having low, intermediate, and high risks, respectively. Androgen deprivation therapy was administered in 244 patients. The biochemical relapse-free rate in the low-, intermediate-, and high-risk groups at 3 years was 87.5%, 88.0%, and 97.5%, respectively (P = 0.036). Grade 2 acute urinary toxicity was observed in 12 (4.7%) patients. Grade 2 acute rectal toxicity was not observed. Grade 2 late urinary toxicity and grade 2 late rectal toxicity were observed in 17 (6.7%) and 3 patients (1.2%), respectively. Previous transurethral resection of the prostate was significantly associated with late grade 2 toxicity in univariate analysis. The predictive factor for late rectal toxicity was not detected.Conclusion: The present study demonstrated that CIRT using the spot scanning method for prostate cancer produces favorable outcomes.

show abstract

Late Genitourinary Toxicity Outcomes in 300 Prostate Cancer Patients Treated With Dose-escalated Image-guided Intensity-modulated Radiotherapy

Cited by 16 publications

References 43 publications

Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer

Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer

Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer

Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer

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