Late Gadolinium Enhancement Imaging in Assessment of Myocardial Viability

Juan, Laura Jimenez; Crean, Andrew M.; Wintersperger, Bernd J.

doi:10.1016/j.rcl.2014.11.004

Cited by 32 publications

(16 citation statements)

References 96 publications

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“…In LGE CMR, an inversion recovery sequence is usually employed to differentiate hyperintensity of infarcted tissue from the adjacent hypo-intensity of normal tissue ( 22 23 ). Inversion time is adjusted to null normal myocardial signals ( 24 ). In other pre-clinical studies, cine LGE CMR represents an attractive alternative to inversion recovery-based LGE CMR for assessing infarct size in mice at high field strengths (7T) ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Self-Gated Late Gadolinium Enhancement at 7T to Image Rats with Reperfused Acute Myocardial Infarction

et al. 2018

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ObjectiveA failed electrocardiography (ECG)-trigger often leads to a long acquisition time (TA) and deterioration in image quality. The purpose of this study was to evaluate and optimize the technique of self-gated (SG) cardiovascular magnetic resonance (CMR) for cardiac late gadolinium enhancement (LGE) imaging of rats with myocardial infarction/reperfusion.Materials and MethodsCardiovascular magnetic resonance images of 10 rats were obtained using SG-LGE or ECG with respiration double-gating (ECG-RESP-gating) method at 7T to compare differences in image interference and TA between the two methods. A variety of flip angles (FA: 10°–80°) and the number of repetitions (NR: 40, 80, 150, and 300) were investigated to determine optimal scan parameters of SG-LGE technique based on image quality score and contrast-to-noise ratio (CNR).ResultsSelf-gated late gadolinium enhancement allowed successful scan in 10 (100%) rats. However, only 4 (40%) rats were successfully scanned with the ECG-RESP-gating method. TAs with SG-LGE varied depending on NR used (TA: 41, 82, 154, and 307 seconds, corresponding to NR of 40, 80, 150, and 300, respectively). For the ECG-RESP-gating method, the average TA was 220 seconds. For SG-LGE images, CNR (42.5 ± 5.5, 43.5 ± 7.5, 54 ± 9, 59.5 ± 8.5, 56 ± 13, 54 ± 8, and 41 ± 9) and image quality score (1.85 ± 0.75, 2.20 ± 0.83, 2.85 ± 0.37, 3.85 ± 0.52, 2.8 ± 0.51, 2.45 ± 0.76, and 1.95 ± 0.60) were achieved with different FAs (10°, 15°, 20°, 25°, 30°, 35°, and 40°, respectively). Optimal FAs of 20°–30° and NR of 80 were recommended.ConclusionSelf-gated technique can improve image quality of LGE without irregular ECG or respiration gating. Therefore, SG-LGE can be used an alternative method of ECG-RESP-gating.

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Section: Discussionmentioning

confidence: 99%

Self-Gated Late Gadolinium Enhancement at 7T to Image Rats with Reperfused Acute Myocardial Infarction

et al. 2018

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“…Similarly, in old myocardial infarction areas, the contrast agent accumulates in the interstitial space because of the fibrotic tissue that replaces the normal one. 23 Thus, the infarcted myocardium appears hyperenhanced, the microvascular obstruction zone is hypoenhanced (this phenomenon was observed in 20-50% of patients after revascularization according to Ahmed et al), and the normal myocardium appears black (is "nulled"), providing a high contrast between the viable and non-viable myocardial tissue. 24,25 These modifications are correlated with non-viable myocardium and frequently occur in dysfunctional segments.…”

Section: Assessment Of Myocardial Viabilitymentioning

confidence: 99%

“…12 Usually, the analysis of the myocardium is performed in the short-axis orientation with additional singleslice long axis outlook in 4, 3, and 2 chambers. 23 Furthermore, to assess and quantify myocardial fibrosis and global viability, MRI evaluates the possible chances of myocardial recovery, attempting to distinguish the 17 segments of the left ventricle. Ortiz-Perez et al have analyzed the relationship between the 17 segments to identify the late gadolinium enhancement pattern of the culprit lesion on angiography following an acute myocardial infarction.…”

Section: Assessment Of Myocardial Viabilitymentioning

confidence: 99%

See 1 more Smart Citation

Cardiac Magnetic Resonance and Myocardial Viability: Why Is It so Important?

Rodean¹,

Beganu²,

Hodaş³

et al. 2017

Journal of Interdisciplinary Medicine

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For a better assessment of ischemic heart diseases, myocardial viability should be quantified. Current studies underline the importance and the evolution of several techniques and methods used in the evaluation of myocardial viability. Taking into account these considerations, the aim of this manuscript was to present the recent points of view regarding myocardial viability and its clinical significance in patients with ischemic cardiomyopathies and left ventricular dysfunction. On the other hand, the manuscript points out the role of magnetic resonance imaging (MRI), one of the most useful noninvasive imaging techniques, in the assessment of myocardial viability. By comparing the advantages and disadvantages of cardiac MRI, its usefulness can be better appreciated by the clinician. In the following years, it is considered that MRI will be an indispensable imaging tool in the assessment of ischemic heart disease, guiding interventions for revascularization and long-term risk stratification in patients with stable angina or myocardial infarction.

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“…The 3D technique allows free breathing navigated image acquisition, or shortened, volumetric acquisitions, at the cost of prolonged image acquisition time, and/or compromised signal to noise ratios, while the continuous interplay of contrast washout and scar enhancement evolves. Eventually, this interplay results in suboptimal suppression of healthy myocardial signal [53], in the later stages of enhancement.…”

Section: Cardiac Magnetic Resonance Imagingmentioning

confidence: 99%