Late febrile convulsions: A clinical follow-up

Pavone, Lorenzo; Cavazzuti, Giovan Battista; Incorpora, Gemma; Galli, Vanna; Parano, Enrico; Benatti, A; Rizzo, Renata; Ciccarone, Vanna

doi:10.1016/s0387-7604(89)80095-6

Cited by 11 publications

(13 citation statements)

References 6 publications

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“…The incidence of developing epilepsy was 3.5% in children who experienced febrile seizures in the early years of life, and this figure rose to 15.8% in those who had their first febrile seizure after the age of 6 years. 21,22 In contrast, another study reported that the risk of developing epilepsy in the later cohort is small. 23 In this study, the age of onset of the two cases of epilepsy was under 5 years; they had recurrent simple febrile seizures and there was no first-degree relative history of febrile seizures or epilepsy.…”

Section: Discussionmentioning

confidence: 98%

Retrospective Study of Febrile Seizures: Subsequent Electroencephalogram Findings, Unprovoked Seizures and Epilepsy in Adolescents

et al. 2002

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A retrospective questionnaire to determine the prevalence of febrile seizures was given to adolescents (16-and 17-year-olds) in the final 2 years of secondary school at the five schools in Alexandroupolis, Greece. Parents were interviewed, and clinical and electroencephalographic examinations were performed in all adolescents with a history of febrile seizures. Of 1708 adolescents, 56 (3.3%) had experienced at least one febrile seizure. Of these, 44 (78.6%) were simple and 12 (21.4%) were complex febrile seizures. Recurrent seizures occurred in 22 cases (39.3%), and the mean age at onset was 25.1 months. There was a positive first-degree family history in eight cases (14.3%) and this increased to 27.3% in cases with recurrent seizures. Two of the adolescents (3.6%) had had one unprovoked seizure before the age of 3 years, and another two children developed epilepsy. Epileptiform electroencephalogram discharges were observed in only one case (1.8%) with generalized tonic-clonic epilepsy.

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Section: Discussionmentioning

confidence: 98%

Retrospective Study of Febrile Seizures: Subsequent Electroencephalogram Findings, Unprovoked Seizures and Epilepsy in Adolescents

et al. 2002

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“…Moreover, the older literature contains numerous examples of families and individuals compatible with GEFS ϩ . 1,[17][18][19][20][21] We suspect that GEFS ϩ is a common form of childhood epilepsy. Determination of its prevalence will require formal epidemiological study.…”

Section: Diagnosis and Frequency Of Gefs ϩmentioning

confidence: 99%

Generalized epilepsy with febrile seizures plus: A common childhood-onset genetic epilepsy syndrome

et al. 1999

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We examined the phenotypic variation and clinical genetics in nine families with generalized epilepsy with febrile seizures plus (GEFS+). This genetic epilepsy syndrome with heterogeneous phenotypes was hitherto described in only one family. We obtained genealogical information on 799 individuals and conducted detailed evaluation of 272 individuals. Ninety‐one individuals had a history of seizures and 63 had epilepsy consistent with the GEFS+ syndrome. Epilepsy phenotypes were febrile seizures (FS) in 31, febrile seizures plus (FS+) in 15, FS+ with other seizure types (atonic, myoclonic, absence, or complex partial) in 8, and myoclonic–astatic epilepsy in 9 individuals. Inheritance was autosomal dominant with approximately 60% penetrance. This study confirms and expands the spectrum of GEFS+ and provides new insights into the phenotypic relationships and genetics of FS and the generalized epilepsies of childhood. Moreover, the ability to identify large families with this newly recognized common, childhood‐onset, generalized genetic epilepsy syndrome suggests that it should be a prime target for attempts to identify genes relevant to FS and generalized epilepsy. Ann Neurol 1999;45:75–81

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“…Duration of recognized fever lasting longer than 24 hours before seizure onset showed a high hazard ratio (37 times) in our study, which is not significant. For younger children, no association between the duration of precedent fever and a recurrence rate of unprovoked seizures has been found 9,14,17) . Our study also showed a high hazard ratio (5 times) for the presence of more than two complex features; focal seizure (2.2 times) and multiple episodes (1.4 times) ( Table 2).…”

Section: Discussionmentioning

confidence: 97%

“…Our study revealed that an unprovoked seizure recurred in seven of 79 patients (9%) following a first late-onset febrile seizure. We also reviewed previous studies regarding the prognosis of either first (Table 4) 6,[9][10][11][12][13] .…”

Section: Discussionmentioning

confidence: 99%

“…Our study also showed a high hazard ratio (5 times) for the presence of more than two complex features; focal seizure (2.2 times) and multiple episodes (1.4 times) ( Table 2). On literatures, the recurrence rate of unprovoked seizure after a first febrile seizure has been reported as 4-27% for complex febrile seizures 9,14,15,17,18) and up to 49% for those with all three features of complex febrile seizures in children younger than five years 17) .…”

Section: Discussionmentioning

confidence: 99%

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Prognosis in Late-Onset Febrile Seizure

Baek¹,

Hwang²,

Jung-Hye³

et al. 2017

journalofthekoreanchildneurologysociety

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Prognosis in Late-Onset Febrile SeizurePurpose: There is a paucity of evidence about prognosis after a first febrile seizure in older children. We investigated the prognosis and potential risk factors associated with subsequent unprovoked seizures in children who had experienced a first febrile seizure over 6 years of age, which we termed as late-onset febrile seizure. Methods: We included all patients six years or older who presented to the emergency department with a febrile seizure between 2009 and 2015. Clinical data was collected by chart review and parents were contacted for information on seizure progress. We used the Cox proportional-hazards model and Kaplan-Meier analysis for evaluating the risk factors for subsequent unprovoked seizures. Results: Of 247 patients, we excluded 168 children who had a history of epilepsy, unprovoked, or febrile seizure and who were followed-up for period less than six months. Overall, 79 patients were classified as having had a first late-onset febrile seizure. During follow-up of 34.9±25.7(mean±SD) months, unprovoked seizure recurred in 7 of 79 patients (9%). The cumulative probability of seizure recurrence was 4% at 6 months, 6% at 1 year and 9% at 2 years. Clinical variables predictive of subsequent unprovoked seizures were not proved. Conclusion: This is the first multicenter study focusing on prognosis after a lateonset febrile seizure in children six years or older. The percentage of subsequent unprovoked seizure in patients with late-onset febrile seizure was 9% at 2 years of follow-up. Prospective follow-up study with longer duration is warranted.

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Late febrile convulsions: A clinical follow-up

Cited by 11 publications

References 6 publications

Retrospective Study of Febrile Seizures: Subsequent Electroencephalogram Findings, Unprovoked Seizures and Epilepsy in Adolescents

Retrospective Study of Febrile Seizures: Subsequent Electroencephalogram Findings, Unprovoked Seizures and Epilepsy in Adolescents

Generalized epilepsy with febrile seizures plus: A common childhood-onset genetic epilepsy syndrome

Prognosis in Late-Onset Febrile Seizure

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