Since Ancient Egypt up to present day, there have constantly been attempts at creating a perfect ocular prosthesis, which would complement the outstanding deficit in the orbit as a result of enucleation, evisceration and which should be biocompatible with the orbital tissue. Over time, there have been used numerous clinical materials, which were the basis of these eye prostheses. By revising literature through the search engines PubMed, MEDLINE and other sources, this article aims at emphasizing, in a chronological sequence, the way in which different types of ocular prostheses were created, but also their advantages and disadvantages. The evolution and design of biomaterials improved the eye rehabilitation process and reduced the complications caused by these prostheses in the anophthalmic socket.