Late Effects of Fast Neutrons and Gamma Rays in Mice as Influenced by the Dose Rate of Irradiation: Life Shortening

Hematotoxicity and Carcinogenicity of Inhaled Benzene

“…It has been known for years by the present investigators that four strains of mice developed an increased incidence of acute myelogenous leukemia after exposure to ionizing radiation (50)(51)(52)(53)(54). The RFM strain is less desirable because of expense and it has a high spontaneous incidence of acute myeloblastic and other leukemias.…”

Annex D. Radiation Effects in Reference Animals and Plants

“…(D12) No effects have been observed on the life span of adult mice after exposure to 11 mGy/day gamma radiation or lower (up to 526 days; total dose 5.8 Gy) (Upton et al, 1967). Mice irradiated with 22.9 mGy/day gamma radiation (total dose 8 Gy) showed some decrease in life span (11-14% reduction, depending on gender) (Tanaka et al, 2003).…”

“…Mice irradiated with 22.9 mGy/day gamma radiation (total dose 8 Gy) showed some decrease in life span (11-14% reduction, depending on gender) (Tanaka et al, 2003). A decrease in life span of 20-30% was seen in mice exposed to 23 mGy/day gamma radiation (total dose 5.8 Gy) (Mole and Thomas, 1961;Upton et al, 1967;Thomson and Grahn, 1989). Exposure to 120 mGy/day (total dose 35.4 Gy) led to a 50% decrease in life span (Spalding et al, 1964), while 500 mGy/day (total dose 14 Gy) reduced life span by more than 60% (Mole and Thomas, 1961).…”

Tumour Incidence and Longevity in Neutron and Gamma-irradiated Rabbits, with an Assessment of R.b.e.

“…1960, Darden, Cosgrove, Upton, Christenberry, Conklin and Davies 1967, Upton, Randolph and Conklin 1967, Covelli, Di Paola, Bassani and Metalli 1976 . values of 1 .…”