Late Effects of Childhood Malignancies seen in Western Australia

Crooks, GM; Baron-Hay, G S; Byrne, G C; Cameron, F.; Hookings, P; Keogh, E.J.; MacKellar, Alasdair; Price, P J; Stuckey, Bronwyn; Campbell, Sarah

doi:10.1097/00043426-199124000-00009

Cited by 6 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This can be compared to a long-term endocrine failure rate of 91 % when all hypothalamic-pituitary axes are considered. This long-term endocrine failure rate reflects both tumor and radiation therapy effects [28], The incidence of growth hormone deficiency in long-term sur vivors of acute lymphoblastic leukemia may be as high as 33% in patients who receive greater than or equal to 24 cGy of cranial irradiation [29], Among our patients the likelihood of resecting greater than 50% of the tumor was higher in those with a diame ter greater than 25 mm (table 2). Our impression that larg er tumors are more amenable to debulking.…”

Section: Surgical Morbiditymentioning

confidence: 73%

Optic Chiasm Astrocytomas of Childhood

Medlock¹,

Scott²

1997

Pediatr Neurosurg

View full text Add to dashboard Cite

We presented our experience from 1975 to 1994 with emphasis on the long term follow-up of children with optic chiasm astrocytomas in part I. In part II we describe the surgical management of 20 patients with the diagnosis of an astrocytoma of the optic chiasm confirmed by biopsy. These patients underwent surgery by the senior author between 1988 and 1994. The patients and the tumors in this series are comparable in age, sex, and presentation and imaging characteristics to other series. Surgery was undertaken with the intent to reduce tumor volume and mass effect and in certain cases to confirm the diagnosis. The patients’ mean age at the time of surgery was 81 (range 18–216) months. The surgical approaches used were pterional in 11 patients, transorbital/subfrontal in 8, and subfrontal in 1 patient. Greater than 50% of the tumor was resected in 8 patients, less than 50% was resected in 9, and biopsy only was achieved in 3 patients. Larger tumors were more likely to have magnetic resonance imaging documented debulking of tumor. Permanent morbidity included mild visual loss, diabetes insipidus, mild hemiparesis, and panhypopituitarism in 1 patient each. There was no surgical mortality. The likelihood of resecting greater than 50% of the tumor was higher in those with a diameter greater than 25 mm. The indications for craniotomy are (1) to debulk symptomatic tumors greater than 50 mm in diameter which are exophytic or cystic; (2) to relieve obstruction at the foramen of Monro, and (3) for diagnostic biopsy.

show abstract

Section: Surgical Morbiditymentioning

confidence: 73%

Optic Chiasm Astrocytomas of Childhood

Medlock¹,

Scott²

1997

Pediatr Neurosurg

View full text Add to dashboard Cite

show abstract

“…The inhibitory effect of radiation on osteogenesis commonly manifests as hypoplasia of bones among survivors of childhood cancer (45, 48, 50, 51, 55, 66), reported especially in flat bones (21, 33, 42, 45–47, 50, 66–69). In a study of 89 survivors of various childhood cancers treated at a median age of 3.8 years and followed for an average of 10.8 years, Crooks et al .…”

Section: Resultsmentioning

confidence: 99%

“…In a study of 89 survivors of various childhood cancers treated at a median age of 3.8 years and followed for an average of 10.8 years, Crooks et al . (48) observed a higher prevalence of skeletal hypoplasia among survivors treated with > 25 Gy than among those treated with ≤ 25 Gy radiation (9/16 vs. 0/8).…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Selected Musculoskeletal Late Effects in Survivors of Childhood Cancer

Gawade¹,

Hudson²,

Kaste³

et al. 2015

CPR

View full text Add to dashboard Cite

Survivors of childhood cancer are at risk for treatment-related musculoskeletal late effects. Early detection and orthopedic intervention can help ameliorate musculoskeletal late effects and prevent subsequent complications. This systematic review summarizes the literature describing associations between cancer, its treatment, and musculoskeletal late effects. We searched PubMed and Web of Science for English language articles published between January 1970 and December 2012. The search was limited to investigations with at least 15 participants and conducted at least 2 years after completion of therapy for childhood, adolescent, or young adult cancer. Some late skeletal effects, including low bone mineral density, osteonecrosis, slipped capital femoral epiphyses, oncogenic rickets, and hormone-related growth disturbances have been previously reviewed and were excluded, as were outcomes following amputation and limb-salvage procedures. Of 2347 references identified, 30 met inclusion criteria and were retained. An additional 54 studies that met inclusion criteria were found in reference lists of retained studies. Of 84 studies, 60 focused on associations between radiotherapy, six between chemotherapy, and 18 between surgery and musculoskeletal late effects. We found that younger age, higher radiation dosage, and asymmetric or partial bone radiation volume influences the effects of radiation on the musculoskeletal system. Methotrexate and vincristine are associated with long-term muscular strength and flexibility deficits. Laminectomy and chest wall resection are associated with spinal malalignment, and enucleation is associated with orbital deformities among survivors. Radiotherapy, chemotherapy, and surgery are associated with musculoskeletal late effects independently and additively. Associations are additionally influenced by host and treatment characteristics.

show abstract

“…3 Skeletal hypoplasia was found in 9 of 16 patients (56%) treated with doses greater than 25 Gy. 9 Furthermore, after pelvic radiation, low bone-mineral density resulting in osteoporosis or insufficiency fractures can occur. 10 Slipped capital femoral epiphysis after radiation has a reported incidence of 10% to 18% and is noted to occur at a younger age than expected-mean age, 10.4 years-in patients who received prior pelvic radiation.…”

Section: Target the Entire Vertebral Body And Minimize Dose To The Fe...mentioning

confidence: 99%