Late diagnosis of intraplacental choriocarcinoma co-existing with fetomaternal haemorrhage causing fetal demise: A case report

Monteiro, Sofia; Burling, Michael; Doyle, Helen

doi:10.1016/j.crwh.2021.e00341

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…At present, only 5 cases with subsequent pregnancy have been reported, [ 6 , 9 , 15 , 16 ] all of them were nonmetastatic IC cases, with good maternal and infant outcomes.…”

Section: Resultsmentioning

confidence: 99%

Long-term outcome and fertility results of intraplacental choriocarcinoma: a retrospective study of 14 patients and literature review

Liu,

Song,

Zhang

et al. 2024

Orphanet J Rare Dis

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Backgrounds Intraplacental choriocarcinoma (IC) is an extremely rare subtype of gestational choriocarcinoma. The long-term follow-up and reproductive outcomes of IC patients remain unclear. Here, we report a series of 14 cases and conduct a literature review to assess the fertility and recurrence results of this rare disease. Results Fourteen patients with pathologically confirmed IC treated in Peking Union Medical College Hospital between January 2002 and July 2022 were included in this study. Half of them had metastatic IC and were treated by chemotherapy with or without surgery. Only 1 patient had chemoresistant disease, but she achieved complete remission after immunotherapy. The median follow-up time was 45.5 months (range 4-192), and no recurrence occurred. One metastatic IC patient who achieved remission after chemotherapy had a full-term delivery. Among the 5 patients with fertility demands, 3 abandoned their pursuit of pregnancy because of “fear and worry about choriocarcinoma recurrence”. We reviewed a total of 89 cases of IC in English and Chinese literature from 1963 to 2022, and only 5 cases with subsequent pregnancy were reported, all of them were nonmetastatic IC cases. Conclusions IC is sensitive to chemotherapy and has good long-term remission and a low recurrence rate. Patients with metastatic or nonmetastatic IC can have good pregnancy results after treatment. Doctors should pay more attention to the psychology of these patients. Clinical trial registration N/A.

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“…At present, only 5 cases with subsequent pregnancy have been reported, [ 6 , 9 , 15 , 16 ] all of them were nonmetastatic IC cases, with good maternal and infant outcomes.…”

Section: Resultsmentioning

confidence: 99%

Long-term outcome and fertility results of intraplacental choriocarcinoma: a retrospective study of 14 patients and literature review

Liu,

Song,

Zhang

et al. 2024

Orphanet J Rare Dis

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“…When the blood type of the fetus is incompatible with that of the mother, antibodies against fetal RBCs are produced in the mother. These antibodies pass through the placenta and cause the destruction of fetal RBCs ( Troia et al, 2019 ; Hookins and Vatsayan, 2020 ; Monteiro et al, 2021 ). 16 weeks is the earliest placenta rupture, so pregnant women at 16 weeks are at risk for FMH ( Akorsu et al, 2019 ; Athiel et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Prenatal diagnosis of fetomaternal hemorrhage by a novel hydrogel fluoroimmunoassay that accurately quantifies fetal haemoglobin

Yin

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Objective: Fetomaternal hemorrhage (FMH) is an alloimmunization resulting caused by the incompatibility between fetal and maternal blood. For the prevention of newborn haemolytic disease (HDN), it is crucial to quantify the amount of fetomaternal hemorrhage. However, the classical Kleihauer–Betke test (K-B test) for detecting fetomaternal hemorrhage is limited by experimental tools and conditions and is not suitable for routine clinical use. Consequently, the method of prenatal diagnosis of fetomaternal hemorrhage applicable to the clinic is a topic worthy of further study. Therefore, it is worthwhile to further investigation on the clinically applicable prenatal diagnosis method for fetomaternal hemorrhage.Methods: This experiment demonstrates hydrogel’s ability to separate sensitized red blood cells from soluble antibodies. Using flow cytometry the fluorescence values of sensitized red blood cells and fluorophore-labeled antibodies were measured, and the testing steps for the detection products of a novel technology were determined. The properties of a hydrogel fluoroimmunoassay were evaluated by distinguishing between the amounts of fetal and adult haemoglobin. The precision of this technology is evaluated using the Kleihauer–Betke test as a comparison.Results: This experiment compared the detection of haemoglobin fluorescence in adults (n = 2) and fetuses (n = 6). At the same time, the fluorescence intensity of different fetal haemoglobin (HbF) in adult haemoglobin (HbA) was calculated. The fluorescence value is 1.6% when the fetal hemoglobin concentration is 0.1%.Conclusion: The novel hydrogel fluoroimmunoassay can accurately determine the fluorescence intensity by flow cytometry to differentiate fetal haemoglobin from adult haemoglobin, quantitatively prenatally diagnose fetal haemoglobin, address the incompatibility between fetal and maternal blood types, and prevent alloimmunization.

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“…It may lead to fetal anemia, jaundice, edema, and even death ( Carr et al, 2022 ). There are numerous causes of placenta rupture, but the most common are trauma and intrauterine death ( Davis, 2019 ; Hsia et al, 2019 ; Hookins and Vatsayan, 2020 ; Monteiro et al, 2021 ). In the United States, 40% of pregnant women die from trauma, according to statistics ( Krywko et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

A novel enzyme-linked immunostaining technique based on silk membrane for the prenatal detection of fetomaternal haemorrhage

Li,

Duan

et al. 2023

Front. Bioeng. Biotechnol.

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Objective: Developing a simple, rapid, reliable, sensitive, and cost-effective method for prenatal detection of fetomaternal haemorrhage by combining multi-aperture silk membrane with enzyme-linked immunosorbent assay (ELISA), which does not require any complicated instruments and can be visually colored, so as to provide a new method for clinical detection of fetomaternal haemorrhage.Methods: As a carrier, a chemically treated silk membrane was used to immobilize anti-A/anti-B antibody reagent. PBS washed slowly after vertically dropping red blood cells. After adding biotin-labeled anti-A/anti-B antibody reagent, PBS is slowly washed, enzyme-labeled avidin is added, and TMB is used for color development after washing.Results: When there were both anti-A and anti-B fetal erythrocytes in pregnant women’s peripheral blood, the final color was dark brown. When there are no anti-A and anti-B fetal red blood cells in pregnant women’s peripheral blood, the final color development results do not change, which corresponds to the color of chemically treated silk membrane.Conclusion: The new enzyme-linked immunosorbent assay (ELISA) based on a silk membrane can distinguish fetal red blood cells from maternal red blood cells prenatally and can be used for prenatal detection of fetomaternal haemorrhage.

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Late diagnosis of intraplacental choriocarcinoma co-existing with fetomaternal haemorrhage causing fetal demise: A case report

Cited by 4 publications

References 12 publications

Long-term outcome and fertility results of intraplacental choriocarcinoma: a retrospective study of 14 patients and literature review

Long-term outcome and fertility results of intraplacental choriocarcinoma: a retrospective study of 14 patients and literature review

Prenatal diagnosis of fetomaternal hemorrhage by a novel hydrogel fluoroimmunoassay that accurately quantifies fetal haemoglobin

A novel enzyme-linked immunostaining technique based on silk membrane for the prenatal detection of fetomaternal haemorrhage

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