Late Diagnosis of Autism Spectrum Disorder After Initial Negative Assessment by a Multidisciplinary Team

Davidovitch, Michael; Levit‐Binnun, Nava; Golan, Dafna; Manning-Courtney, Patricia

doi:10.1097/dbp.0000000000000133

Cited by 79 publications

(89 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At age 7, however, their ADI and ADOS scores were high and adaptive behaviour was low, similar to the “Stable diagnosis” group, despite having high‐average intelligence (Table S2). A similar pattern of findings has been reported for later‐diagnosed high‐risk children [Brian et al, ] and in clinical samples [Davidovitch, Levit‐Binnun, Golan & Manning‐Courtney, ]. The “Later diagnosed” subgroup also had high ADHD scores and the highest anxiety scores at 7 (Table S2).…”

Section: Discussionsupporting

confidence: 82%

Mid‐childhood outcomes of infant siblings at familial high‐risk of autism spectrum disorder

et al. 2016

View full text Add to dashboard Cite

Almost 20% of infants with an older sibling with autism spectrum disorder (ASD) exhibit ASD themselves by age 3 years. The longer‐term outcomes of high‐risk infants are less clear. We examined symptoms of ASD, attention‐deficit/hyperactivity disorder (ADHD) and anxiety, language, IQ, and adaptive behaviour at age 7 years in high‐ and low‐risk children prospectively studied since the first year of life. Clinical outcomes were compared between high‐risk children who met diagnostic criteria for ASD at age 7 (HR‐ASD‐7 group, n = 15), high‐risk children without ASD (HR‐Non‐ASD‐7 group, n = 24), and low‐risk control children (LR group, n = 37). Diagnostic stability between age 3 and 7 years was moderate, with five children who did not meet diagnostic criteria for ASD at age 3 years being assigned the diagnosis at age 7, and three children showing the opposite pattern. The HR‐ASD‐7 group showed elevated ADHD and anxiety symptoms and had lower adaptive behaviour scores than LR controls. The HR‐Non‐ASD‐7 group had higher repetitive behaviour, lower adaptive functioning and elevated scores on one anxiety subscale (Separation Anxiety) compared to LR controls, but evidence for subclinical ASD symptoms (the broader autism phenotype, BAP) was limited in the group as a whole, although we identified a subgroup with elevated ASD traits. The difficulties experienced by high‐risk siblings at school‐age extend beyond ASD symptoms. The pattern of difficulties exhibited by the HR‐ASD‐7 group may inform our understanding of developmental trajectories of co‐occurring psychopathology in ASD. Autism Res 2017, 10: 546–557. © The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research

show abstract

Section: Discussionsupporting

confidence: 82%

Mid‐childhood outcomes of infant siblings at familial high‐risk of autism spectrum disorder

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Another limitation relates to age of diagnosis. While diagnoses made at age 2 years are relatively stable over time (Lord et al., ; Shen et al., ), there is variability associated with ASD onset and we expect that diagnostic status will change for a small proportion our sample as they age (Davidovitch, Levit‐Binnun, Golan, & Manning‐Courtney, ; Ozonoff et al., ). Whether the pattern of results observed here will generalize across a wider age range is an important issue, and we are currently following‐up participants from the present study at school‐age to account for later childhood outcomes.…”

Section: Discussionmentioning

confidence: 98%

A longitudinal study of parent‐reported sensory responsiveness in toddlers at‐risk for autism

Wolff

Dimian

Botteron

et al. 2018

Child Psychology Psychiatry

View full text Add to dashboard Cite

Background Atypical sensory responsivity and sensory interests are now included in the DSM 5 diagnostic criteria for autism spectrum disorder (ASD) under the broad domain of restricted and repetitive behavior (RRB). However, relatively little is known about the emergence of sensory‐related features and their relation to conventionally defined RRB in the first years of life. Methods Prospective, longitudinal parent‐report data using the Sensory Experiences Questionnaire (SEQ) were collected for 331 high‐risk toddlers (74 of whom met diagnostic criteria for ASD at age 2) and 135 low‐risk controls. Longitudinal profiles for SEQ scores were compared between groups across ages 12–24 months. Associations between SEQ measures and measures of RRB subtypes (based on the Repetitive Behavior Scale, Revised) were also examined. Results Longitudinal profiles for all SEQ scores significantly differed between groups. SEQ scores were elevated for the ASD group from age 12 months, with differences becoming more pronounced across the 12–24 month interval. At both 12 and 24 months, most measures derived from the SEQ were significantly associated with all subtypes of RRB. Conclusions These findings suggest that differences in sensory responsivity may be evident in high‐risk infants later diagnosed with ASD in early toddlerhood, and that the magnitude of these differences increases over the second year of life. The high degree of association between SEQ scores and RRB supports the conceptual alignment of these features but also raises questions as to explanatory mechanisms.

show abstract

“…Similar to our findings, Frenette et al (2011) reported that in children with a diagnosis of ADHD, attention and hyperactivity symptoms masked core ASD symptoms and could explain why they were diagnosed 1.29 years later than those without ADHD. Further, Davidovitch et al (2015) reported that almost half of children later diagnosed with ASD were initially diagnosed with ADHD features and behaviors problems. The potential “masking effect” of ADHD symptoms on the diagnosis of ASD may lead clinicians to consider primarily a diagnosis of ADHD instead of ASD.…”

Section: Discussionmentioning

confidence: 99%

“…Some co-occurring conditions/symptoms can mask or modify the expression of the core ASD symptoms, which may result in later age of diagnosis or loss of a previous diagnosis (Blumberg et al 2016; Close et al 2012; Davidovitch et al 2015; Jonsdottir et al 2011; Levy et al 2010; Mandell et al 2007; Mazurek et al 2014; Wiggins et al 2012; Wu et al 2016). For example, Davidovitch et al (2015) found that children with language or cognitive deficits, or attention or motor problems were more likely to be diagnosed with ASD after the age of 6 years, even though they were initially evaluated at a younger age. A current or past developmental condition (e.g., developmental delay, hearing problem) or other disorders, such as anxiety or epilepsy, was associated with a loss of a previous ASD diagnosis (Close et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Co-occurring Medical and Behavioral Conditions/Symptoms Among 4- and 8-Year-Old Children with Autism Spectrum Disorder in Selected Areas of the United States in 2010

Soke

Maenner

Christensen

et al. 2018

J Autism Dev Disord

158

153

View full text Add to dashboard Cite

We compared the prevalence of various medical and behavioral co-occurring conditions/symptoms between 4- and 8-year-olds with autism spectrum disorder (ASD) from five sites in the Autism and Developmental Disabilities Monitoring Network during the 2010 survey year, accounting for sociodemographic differences. Over 95% of children had at least one co-occurring condition/symptom. Overall, the prevalence was higher in 8- than 4-year-olds for 67% of co-occurring conditions/symptoms examined. Further, our data suggested that co-occurring conditions/symptoms increased or decreased the age at which children were first evaluated for ASD. Similarly, among the 8-year-olds, the prevalence of most co-occurring conditions/symptoms was higher in children with a previous ASD diagnosis documented in their records. These findings are informative for understanding and screening co-occurring conditions/symptoms in ASD.

show abstract

Late Diagnosis of Autism Spectrum Disorder After Initial Negative Assessment by a Multidisciplinary Team

Abstract: Subsequent late diagnosis of ASD after an initial ASD-negative comprehensive assessment is a common clinical experience. Reasons for this scenario may include evolving diagnosis as well as missed and overdiagnosed cases of ASD.

Cited by 79 publications

References 13 publications

Mid‐childhood outcomes of infant siblings at familial high‐risk of autism spectrum disorder

Mid‐childhood outcomes of infant siblings at familial high‐risk of autism spectrum disorder

A longitudinal study of parent‐reported sensory responsiveness in toddlers at‐risk for autism

Prevalence of Co-occurring Medical and Behavioral Conditions/Symptoms Among 4- and 8-Year-Old Children with Autism Spectrum Disorder in Selected Areas of the United States in 2010

Contact Info

Product

Resources

About