Late development of bile duct cancer after sphincteroplasty: A ten- to twenty-two-year follow-up study

Hakamada, Kenichi; Sasaki, Makoto; Endoh, Masao; Itoh, Takashi; Morita, Takayuki; Konn, Mitsuru

doi:10.1016/s0039-6060(97)90101-x

Cited by 108 publications

(59 citation statements)

References 18 publications

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“…This may be a cause for concern in younger patients as it can increase the incidence of primary choledocholithiasis caused by deconjugation of the bilirubin by bacterial enzymes, and the number of tumours of biliary origin. Acamada [24] detected primary cancer of the biliary tree detected in 7.4% of patients undergoing transduodenal surgical destruction of the muscle fibres of the sphincter of Oddi after a mean follow-up of 18 (10-22) years. In the majority of these cases, bacterial contamination of the biliary tract was also observed.…”

Section: Discussionmentioning

confidence: 99%

Selective sphincteroplasty of the papilla in cases at risk due to atypical anatomy

Múgica¹,

Urdapilleta²,

Castiella³

et al. 2007

WJG

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Section: Discussionmentioning

confidence: 99%

Selective sphincteroplasty of the papilla in cases at risk due to atypical anatomy

Múgica¹,

Urdapilleta²,

Castiella³

et al. 2007

WJG

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“…Other predisposing factors for CC are diabetes, obesity, presence of bile duct adenomas and biliary papillomatosis [64,65] . Although there is no evidence that endoscopic sphincterotomy increases the risk of CC, biliary-enteric bypasses may do so [66] .…”

Section: Other Risk Factorsmentioning

confidence: 99%

Advances in diagnosis, treatment and palliation of cholangiocarcinoma: 1990-2009

Aljiffry¹,

Walsh²,

Molinari³

2009

WJG

253

190

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Several advances in diagnosis, treatment and palliation of cholangiocarcinoma (CC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. CC is a relatively rare tumor and the main risk factors are: chronic inflammation, genetic predisposition and congenital abnormalities of the biliary tree. While the incidence of intra-hepatic CC is increasing, the incidence of extra-hepatic CC is trending down. The only curative treatment for CC is surgical resection with negative margins. Liver transplantation has been proposed only for selected patients with hilar CC that cannot be resected who have no metastatic disease after a period of neoadjuvant chemo-radiation therapy. Magnetic resonance imaging/ magnetic resonance cholangiopancreatography, positron emission tomography scan, endoscopic ultrasound and computed tomography scans are the most frequently used modalities for diagnosis and tumor staging. Adjuvant therapy, palliative chemotherapy and radiotherapy have been relatively ineffective for inoperable CC. For most of these patients biliary stenting provides effective palliation. Photodynamic therapy is an emerging palliative treatment that seems to provide pain relief, improve biliary patency and increase survival. The clinical utility of other emerging therapies such as transarterial chemoembolization, hepatic arterial chemoinfusion and high intensity intraductal ultrasound needs further study.

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“…Although the incidence of cholangiocarcinoma has been reported to be relatively low [1, 5], Hakamada et al [1]reported that 7.4% of patients had developed cholangiocarcinoma after transduodenal sphincteroplasty with a mean interval of 18 years. Tocchi et al [2]also reported that the incidence of cholangiocarcinomas after sphincteroplasty, choledochoduodenostomy, and hepaticojejunostomy was 4.8, 7.6, and 1.9%, respectively, with intervals of 11–18 years.…”

Section: Discussionmentioning

confidence: 99%

“…A high frequency of biliary cancer developing after sphincteroplasty and choledochoenteric anastomosis has recently been reported [1, 2]. However, there have been few descriptions or case reports [3, 4]documenting this condition and its complete histological context.…”

Section: Introductionmentioning

confidence: 99%

Bile Duct Cancer Developing 21 Years after Choledochoduodenostomy

et al. 2003

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Background: Cholangiocarcinoma in patients with choledochoenterostomy has been a rare condition with few cases reported in the literature written in English, and there have been few pathological descriptions of this disease. However, it has recently been documented as a late complication of choledochoenteric anastomosis, and has become a serious issue today since choledochoenterostomy and sphincteroplasty for benign biliary lesions were frequently resorted to in the 1970s and 1980s. The authors here present a case of a 67-year-old woman who developed a cholangiocarcinoma 21 years after choledochoduodenostomy. Methods: The patient underwent a curative resection of the tumor with a hepatopancreatoduodenectomy after a detailed preoperative assessment, including cholangiography and cholangioscopy. Results: Although this tumor has been reported to have a poor prognosis, a precise preoperative evaluation and aggressive surgery may contribute to better survival. Pathologically, the tumor originated in the bile duct mucosa of the choledochoduodenostomy, and was accompanied by intestinal and pyloric gland-like metaplasia. Conclusion: These epithelial changes presumably induced by chronic inflammation due to the reflux of intestinal contents and bile stasis may be responsible for the carcinogenesis.

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Late development of bile duct cancer after sphincteroplasty: A ten- to twenty-two-year follow-up study

Cited by 108 publications

References 18 publications

Selective sphincteroplasty of the papilla in cases at risk due to atypical anatomy

Selective sphincteroplasty of the papilla in cases at risk due to atypical anatomy

Advances in diagnosis, treatment and palliation of cholangiocarcinoma: 1990-2009

Bile Duct Cancer Developing 21 Years after Choledochoduodenostomy

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