Late-Convalescent Poliomyelitis

Fishman, Paul S.

doi:10.1001/archneur.1987.00520130076021

Cited by 13 publications

(1 citation statement)

References 19 publications

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“…Post-polio syndrome: clinical manifestations and cerebrospinal fluid markers -REVIEW future science group future science group www.futuremedicine.com single case with exclusive B-cell infiltration has been reported [50]. Notably, Fishman found no evidence of inflammation in seven spinal cords of poliomyelitis survivors [51]. In subjects with new symptoms, the pathological picture was characterized by the presence of axonal spheroids and neuronal chromatolysis, changes regarded as a sign of neuronal dysfunction following increased functional demand [49].…”

Section: A U T H O R P R O O Fmentioning

confidence: 99%

Post-polio syndrome: clinical manifestations and cerebrospinal fluid markers

et al. 2007

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Post-polio syndrome (PPS) refers to a constellation of new neurological, musculoskeletal and general symptoms occurring in survivors of poliomyelitis decades after acute paralytic and nonparalytic disease. The common manifestations of PPS include generalized, central and peripheral fatigue, muscle weakness and musculoskeletal pain. The pathogenesis of PPS remains obscure. Three prevailing hypotheses have been advanced: stress-induced degeneration of surviving neurons, persistent poliovirus replication or virus reactivation and immune-mediated damage. The diagnosis of PPS is based on medical history and clinical examination, since no specific diagnostic tests are available. In the light of recent studies demonstrating a partial beneficial effect of intravenous immunoglobulin, this article will focus on cerebrospinal fluid biomarkers reflecting disease activity and pathogenic processes in PPS. A u t h o r P r o o f2

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Section: A U T H O R P R O O Fmentioning

confidence: 99%

Post-polio syndrome: clinical manifestations and cerebrospinal fluid markers

et al. 2007

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Spinal cord histopathology in long‐term survivors of poliomyelitis

et al. 1995

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Comparative study of spinal cord ubiquitin expression in post-poliomyelitis and sporadic amyotrophic lateral sclerosis

Ito

Hirano

1994

Acta Neuropathol

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This study addresses the suggested possible pathogenetic relationship between the late-onset muscular atrophy in patients with the prior diagnosis of poliomyelitis and amyotrophic lateral sclerosis (ALS). For this purpose we applied immunohistochemical techniques to determine the presence of pathological structures that were stained for ubiquitin (a protein involved in degenerative processes) in the spinal cords of patients with a history of poliomyelitis and compared the results with those of ALS, a condition in which cytoplasmic ubiquitin-positive inclusions are invariably found in the anterior horn cells. Our results indicate that post-poliomyelitis patients have no ubiquitin-reactive inclusion bodies in these cells; however, some immunopositive globular and cord-shaped structures are seen in less-affected areas. Similar structures were also found in the spinal cords from patients with ALS and from normal individuals. Our findings would suggest that the pathogenesis of late muscular atrophy in post-poliomyelitis patients is dissimilar to that of ALS.

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Late-Convalescent Poliomyelitis

Cited by 13 publications

References 19 publications

Post-polio syndrome: clinical manifestations and cerebrospinal fluid markers

Post-polio syndrome: clinical manifestations and cerebrospinal fluid markers

Spinal cord histopathology in long‐term survivors of poliomyelitis

Comparative study of spinal cord ubiquitin expression in post-poliomyelitis and sporadic amyotrophic lateral sclerosis

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