Late Complications Following Heart Transplant

Murad, Khalil; Colvin, Monica

doi:10.1007/978-3-319-44577-9_31

Cited by 2 publications

(3 citation statements)

References 90 publications

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Section: Discussionmentioning

confidence: 99%

“…[16,17] Moreover, it is well-known that valvular dysfunction following cardiac transplantation is not as frequent as CAV, a condition that is responsible for long-term graft dysfunction. [3,18] Tricuspid regurgitation following cardiac transplantation is the most commonly diagnosed valve dysfunction. [6,19] This can be explained with right heart strain and repeated endomyocardial biopsy.…”

Section: Discussionmentioning

confidence: 99%

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Management options of valvular heart diseases after heart transplantation: A scoping review

Yilmaz,

Keenan

2024

Turk Gogus Kalp Dama

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Background: This study aimed to outline the valvular changes following heart transplantation and describe the management options to address these conditions. Methods: A literature search using EMBASE, MEDLINE, and PubMed databases was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines in this study. Clinical studies involving patients who had their first heart transplant and articles that mentioned management for valvular heart disease were included. Treatment options were grouped into four categories: cardiac surgery other than retransplant and valve surgery, valve replacement and repairs, nonsurgical interventions, and conservative management. Results: Nine hundred and three (6.56%) patients out of 13,757 patients (10,529 males, 3,228 females; mean age: 60.3±10.4 years; range, 20 to 83 years) undergoing heart transplantation were identified with valvular disease affecting one or more valves. The mean interval between the transplant and the diagnosis of valve disease was 11.31±6.95 years. The most common valvular heart disease was tricuspid regurgitation, with 796 (94.09%) occurrences, followed by mitral regurgitation (n=22, 2.6%), aortic regurgitation (n=14, 1.65%), aortic stenosis (n=11, 1.3%), and mitral stenosis (n=3, 0.35%). Additionally, the number of surgical valve replacement and repairs (n=89) was higher than nonsurgical interventions (n=20). Conclusion: Acquired valvular heart diseases after cardiac transplantation are an infrequent clinical presentation that can cause valvular changes in the recipient. According to the extracted data, there is no sole superior management option, and more research is needed in this area.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Management options of valvular heart diseases after heart transplantation: A scoping review

Yilmaz,

Keenan

2024

Turk Gogus Kalp Dama

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“…The post‐kidney transplantation status of the central or peripheral nervous system has been discussed in the previous studies. However, the electrophysiological findings have not been investigated .…”

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confidence: 99%

Neurological Complications After Renal Transplantation: A Systematic Review and Meta‐Analysis

2019

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The aim of this systematic review and meta‐analysis was to evaluate the prevalence of neurological complication after renal transplantation. The searches were conducted by two independent researchers in the international (PubMed, Web of Science, Scopus, and Google Scholar) and national databases (Magiran and SID) to find the relevant studies published in English and Persian languages since the creation of the databases until January 2019 (without time limitations). The keywords used in the search strategy were: neurologic complication, central nervous system, peripheral nervous system, tremor, CVA, encephalopathy, neurological complications, renal transplantation, renal failure, kidney transplantation, immunosuppression, neurotoxicity, opportunistic infections, CNS, cerebrovascular disease, chronic kidney disease, cognitive impairment, and end‐stage renal disease, which were combined using the AND, OR, and NOT operators. Finally, a meta‐analysis was conducted in STATA14 statistical software. Based on the random effect model, the total prevalence of neurologic complications in 4674 patients who had undergone the renal transplantation surgery was 7.9% (95% confidence interval [CI]:7.2%,8.7%, I2 = 90.1%). The prevalence of infectious, non‐infectious and treatment associated neurologic complications was 9.5% (95% CI –8.9, 10.2), 91.8% (95% CI –91.3, 92.4) and 97% (95% CI‐95.7%,98.4%) of all neurologic complications in renal transplant patients, respectively. And according to the present subgroup analysis, peripheral neuropathy with a prevalence about 30% (29%) (95% CI –27.6%, 30.4%, I2 = 99.4%) was the most common neurological disorder in renal transplant patients followed by tremor with a prevalence of 19.5% (CI –17.6%, 21.3%, I2 = 97.1%), cerebrovascular events with a prevalence of 15.1% (95% CI –13.9%, 16.4%, I2 = 96.5%), encephalopathy with the prevalence of 13% (95% CI –12%, 14%, I2 = 99.3%), headache with a prevalence of 8.3% (95% CI –6.8%, 9.8%, I2 = 97.3%) and seizure with a prevalence of 7.4% (CI – 6.5%, 8.3%, I2 = 94.6%). The results of the present systematic review and meta‐analysis, suggests that post‐kidney transplantation neurological disorders, with a prevalence rate about 8%, are relatively common; most of them are caused by immunosuppressive drugs and can be treated by decreasing the dose or switching the immunosuppressive drugs. Neurological disorders are associated with increased mortality; thus, differential diagnosis should be conducted for each individual patient with neurological symptoms after transplantation. It is important for all health care providers to become familiar with the symptoms of neurological disorders that may occur after organ transplants. Recognizing and monitoring these symptoms can reduce the risk of death in kidney transplant recipients. Further research is needed to help the transplant community to identify these issues and problems better in order to achieve the ultimate goal of helping renal patients and sending them back into their normal lives.

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Late Complications Following Heart Transplant

Cited by 2 publications

References 90 publications

Management options of valvular heart diseases after heart transplantation: A scoping review

Management options of valvular heart diseases after heart transplantation: A scoping review

Neurological Complications After Renal Transplantation: A Systematic Review and Meta‐Analysis

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