Late Causes of Death in Children Treated for CNS Malignancies

Long-term outcomes and late effects for childhood and young adulthood intracranial germinomas

“…Cumulative incidence of SMN at 25 years was 6.1% for GGCTs and 4.1% for NGGCTs, which is comparable to previously reported cumulative incidence of 6.4% at 30 years for pediatric CNS malignancies. 14 In our cohort, deaths due SMN or recurrent disease accounted for 29 of 54 deaths (54%).…”

“…When analyzing the late causes of death in 5-year survivors of pediatric CNS malignancies, Perkins et al found that 50% of the deaths were attributable to recurrent disease. 14 The CCSS demonstrated that the annual risk of death from recurrence or progression of primary was 0.44% per year, but this varied across diagnostic groups with the highest rates being in Ewing's sarcoma (0.95% per year) and CNS tumors (1.14% per year for medulloblastoma and 0.95% per year for other CNS tumors). 12 Nordic data from populationbased registries assessed cause of death in 37 515 five-year survivors of childhood and adolescent cancer and categorized them as follows: death due to the first cancer, death due to a second or subsequent primary cancer, or death due to a noncancer-related cause.…”

Quality of life and late‐effects among childhood brain tumor survivors: a mixed method analysis

“…Brain tumors (BTs) are the most common solid tumors in childhood [1], and currently, close to 80% of childhood BT patients survive at least 5 years [2]. The survivors have an elevated risk for a number of late-effects [3][4][5][6][7][8]. Quality of life (QOL) has been extensively studied in survivors.…”