Late Cardiac Remodeling After Primary Percutaneous Coronary Intervention

Abstract

Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp t present, the preferred strategy for patients with acute myocardial infarction (AMI) is primary percutaneous coronary intervention (PPCI). This treatment reduces infarct size, preserves left ventricular function and improves survival. 1-3 Nevertheless it does not prevent remodeling. 1,2,4-6 Remodeling can importantly affect the function of the left ventricle and survival because progressive dilatation may ultimately lead to chronic heart failure. Up to 30-46% of the patients treated with thrombolysis show dilatation until 6 months follow-up, and 20% show progressive dilatation even after 6 months. 7,8 Several studies have demonstrated the clear benefits of PPCI in AMI on left ventricular function compared to thrombolysis, 3 but even in patients treated with PPCI up to 27%show progressive dilatation until 6 months. 8 To our knowledge, no studies to date have assessed the effects of PPCI on left ventricular function beyond 2 years. In light of these considerations and given that cardiac magnetic resonance imaging (CMRI) enables in vivo visualization of cardiac function and infarct size over time, 9,10 we investigated the prevalence and pattern of global and regional left ventricular remodeling in combination with infarct size and transmural extent of infarction (TEI) at 3 different time points after AMI: within 10 days, at 4 months and at 5 years.

Extracorporeal Low-Energy Shock-Wave Therapy Exerts Anti-Inflammatory Effects in a Rat Model of Acute Myocardial Infarction

“…1-4 However, left ventricular (LV) remodeling after AMI still remains one of the unsolved problems. 5, 6 Thus, it is crucial to develop new therapeutic strategies to suppress LV remodeling after AMI. We have developed a non-invasive angiogenic therapy with extracorporeal low-energy shock waves (SW), and have demonstrated its efficacy and safety in a porcine model of chronic myocardial ischemia 7 and patients with angina pectoris.…”

Glycemic Variability Determined by Continuous Glucose Monitoring System Predicts Left Ventricular Remodeling in Patients With a First ST-Segment Elevation Myocardial Infarction

“…After scout imaging, cine true fast imaging with steady precession (True-FISP) sequences were obtained. Cine images were acquired in 6-8 short-axis views and typical parameters were as follows: TR 39.2 ms, TE 1.94 ms, FA 80°, 10-mm slice thickness, matrix 115×256, and FOV Glycemic Variability of AMI considered as important predictors of LVR (culprit left anterior descending coronary artery (LAD), 15 the extent of Core, 15, 16 and peak hs-CRP 17 ) (model 1). Next we built a multivariate logistic regression model with forced inclusion variables (HbA1c on admission, glucose on admission, group H) to assess the meaning of GV (model 2).…”

A Dataset from Echocardiographic Assessment of Cardiac Function in Mice after Myocardial Infarction

“…1 The main cause of this failure to recover is the development of cardiac remodelling, a process that leads to a series of structural and functional changes in the viable myocardium. Although progress has been made in understanding the pathophysiology of cardiac remodelling, we are still unable to predict disease progress and lack effective treatments tailored to the needs of the specific patient.…”