Late Breaking Abstract - Maternal asthma, weight gain in early life and infant lung function

Belinelo, Patricia de Gouveia; Jesson, Kathryn; Appenzeller, Rhea; Gorlanova, Olga; Collison, Adam; Oldmeadow, Christopher; Murphy, Vanessa E.; Robinson, Paul D.; Latzin, Philipp; Gibson, Péter G.; Frey, Urs; Mattes, Joërg

doi:10.1183/13993003.congress-2019.oa4937

Cited by 1 publication

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“…We have previously demonstrated that lung function at 6 weeks of age is reduced in babies born to asthmatic mothers. 38 Thus, in this cohort of infants born to asthmatic mothers, the lung function in the top quartile of infants equates with those above the median in previous normative cohorts. 25 tSNE plots allowed the visualisation of distinct cluster distribution between lung function groups for tPTEF/tE% (Figure 3a ) and LCI (Figure 3c ).…”

Section: Resultsmentioning

confidence: 49%

“…Lung function results for both parameters were analysed separately in quartiles with the quartile with the best lung function compared to the three quartiles of lower lung function. We have previously demonstrated that lung function at 6 weeks of age is reduced in babies born to asthmatic mothers 38 . Thus, in this cohort of infants born to asthmatic mothers, the lung function in the top quartile of infants equates with those above the median in previous normative cohorts 25 .…”

Section: Resultsmentioning

confidence: 52%

“…The influence of confounders was assessed by performing uni‐ and multivariable regression analysis. In multivariable analyses performed to identify variables associated with tPTEF/tE%, the following known confounders were included the following: (1) male sex, (2) birth order, (3) exclusive breastfeeding until test date, (4) weight gain from birth until test date and (5) age at lung function test in days 38 . In further analyses, tPTEF/tE% was adjusted by these known confounders.…”

Section: Methodsmentioning

confidence: 99%

“…In multivariable analyses performed to identify variables associated with tPTEF/tE%, the following known confounders were included the following: (1) male sex, (2) birth order, (3) exclusive breastfeeding until test date, (4) weight gain from birth until test date and (5) age at lung function test in days. 38 In further analyses, tPTEF/tE% was adjusted by these known confounders. To identify variables associated with LCI, a univariable analysis was performed after certifying that LCI was not affected by body size.…”

Section: Methodsmentioning

confidence: 99%

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Cord blood group 2 innate lymphoid cells are associated with lung function at 6 weeks of age

et al. 2021

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Objective. Offspring born to mothers with asthma in pregnancy are known to have lower lung function which tracks with age. Human group 2 innate lymphoid cells (ILC2) accumulate in foetal lungs, at 10-fold higher levels compared to adult lungs. However, there are no data on foetal ILC2 numbers and the association with respiratory health outcomes such as lung function in early life. We aimed to investigate cord blood immune cell populations from babies born to mothers with asthma in pregnancy. Methods. Cord blood from babies born to asthmatic mothers was collected, and cells were stained in whole cord blood. Analyses were done using traditional gating approaches and computational methodologies (t-distributed stochastic neighbour embedding and PhenoGraph algorithms). At 6 weeks of age, the time to peak tidal expiratory flow as a percentage of total expiratory flow time (tPTEF/tE%) was determined as well as Lung Clearance Index (LCI), during quiet natural sleep. Results. Of 110 eligible infants (March 2017 to November 2019), 91 were successfully immunophenotyped (82.7%). Lung function was attempted in 61 infants (67.0%), and 43 of those infants (70.5% of attempted) had technically acceptable tPTEF/tE% measurements. Thirty-four infants (55.7% of attempted) had acceptable LCI measurements. Foetal ILC2 numbers with increased expression of chemoattractant receptorhomologous molecule (CRTh2), characterised by two distinct analysis methodologies, were associated with poorer infant lung function at 6 weeks of age." Conclusion. Foetal immune responses may be a surrogate variable for or directly influence lung function outcomes in early life.

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Section: Resultsmentioning

confidence: 49%

Section: Resultsmentioning

confidence: 52%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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