Late Breaking Abstract - Long-term variability of blood eosinophils in COPD patients by GOLD 2017 staging, and gender bias

Soriano, Joan B.; Pastor-Sanz, María Teresa; García-Castillo, Elena; Vázquez, Emma; Gómez-Punter, Rosa Mar; Alonso, Tamara; Ancochea, Julio

doi:10.1183/13993003.congress-2018.pa4065

Cited by 1 publication

(1 citation statement)

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“…Rosenkranz (2020) [44] Santos (2018) [45] Shoemark (2019) [46] Shteinberg (2020) [47] Simpson (2017) [48] Simpson (2018) [49] Soriano (2018) [50] Tay (2018) [51] Tiew (2020) [52] Tiotiu (2018) [53] Toledo-Pons (2019) [54] Meer (2019) [55] Dijk (2020) [56] Yii (2018) [57] Yii (2019) [58] Chung (2019) [59] A maximum of one star for each item within the Selection and Outcome categories. A maximum of two stars can be given for Comparability.…”

Section: Adequacy Of Follow-upmentioning

confidence: 99%

Treatable Traits in Chronic Respiratory Disease: A Comprehensive Review

Lee

Selvakumar

See

2021

Cells

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Chronic respiratory diseases are major contributors to the global burden of disease. While understanding of these diseases has improved, treatment guidelines have continued to rely on severity and exacerbation-based approaches. A new personalised approach, termed the “treatable traits” approach, has been suggested to address the limitations of the existing treatment strategies. We aim to systematically review the current evidence regarding treatable traits in chronic respiratory diseases and to identify gaps in the current literature. We searched the PubMed and Embase databases and included studies on treatable traits and chronic respiratory diseases. We then extracted information on prevalence, prognostic implications, treatment options and benefits from these studies. A total of 58 papers was included for review. The traits identified were grouped into five broad themes: physiological, biochemical, psychosocial, microbiological, and comorbidity traits. Studies have shown advantages of the treatable traits paradigm in the clinical setting. However, few randomised controlled trials have been conducted. Findings from our review suggest that multidisciplinary management with therapies targeted at treatable traits has the potential to be efficacious when added to the best practices currently implemented. This paradigm has the potential to improve the holistic care of chronic respiratory diseases.

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