Late Breaking Abstract - Burden of pertussis in COPD: a retrospective database study in England

Aris, Emmanuel; Akpo, Essè Ifèbi Hervé; Bhavsar, Amit; Harrington, Lauriane; Merinopoulou, Evie; Sawalhi-Leckenby, Nicola; Turriani, Elisa; Meszaros, Kinga; Lambrelli, Dimitra; Mukherjee, Pritish

doi:10.1183/13993003.congress-2020.2468

Cited by 2 publications

(4 citation statements)

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“…50 years with COPD was similar to that of a general cohort of people aged ! 50 years in the same study period, as reported by Aris et al (5.76 events per 100 000 PYFU) [39]. Similar results were observed for !…”

Section: Discussionsupporting

confidence: 86%

Burden of Pertussis in COPD: A Retrospective Database Study in England

Aris

Harrington

Bhavsar

et al. 2021

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Chronic obstructive pulmonary disease (COPD) may increase the risk and severity of pertussis infection. Health care resource utilization (HCRU) and direct medical costs (DMC) of treating pertussis among patients with COPD are unknown. Reported incidence of pertussis among individuals aged ! 50 years with COPD was assessed in Clinical Practice Research Datalink and Hospital Episode Statistics databases during 2009-2018 using a retrospective cohort design. HCRU and DMC from the National Health Service perspective were compared between patients with COPD and pertussis and propensity score-matched patients with COPD without pertussis. Seventy-eight new pertussis events were identified among 387 086 patients with COPD aged ! 50 years (incidence rate: 4.73; 95% confidence interval 3.74-5.91 per 100 000 person-years). HCRU and DMC were assessed among 67 patients with COPD and pertussis and 267 matched controls. During the month before the pertussis diagnosis, the rates of general practitioner (GP)/nurse visits (4289 vs. 1774 per 100 patient-years) and accident and emergency visits (182 vs. 18 per 100 patient-years) were higher in the pertussis cohort; GP/nurse visits (2935 vs. 1705 per 100 patient-years) were also higher during the following 2 months (all p < 0.001). During the month before the pertussis diagnosis, annualized per-patient total DMC were £2012 higher in the pertussis cohort (£3729 vs. £1717; p < 0.001); during the following 2 months, they were £2407 higher (£5498 vs. £3091; p < 0.001). In conclusion, a pertussis episode among individuals with COPD resulted in significant increases in HCRU and DMC around the pertussis event.

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Section: Discussionsupporting

confidence: 86%

Burden of Pertussis in COPD: A Retrospective Database Study in England

Aris

Harrington

Bhavsar

et al. 2021

COPD: Journal of Chronic Obstructive Pulmonary Disease

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“…When comparing our estimate for recent B. pertussis exposure in the AERIS cohort in 2013 (using an anti-PT threshold of 70 IU/mL indicative of B. pertussis infection within the last year) to the reported incidence of clinical pertussis cases in a COPD cohort aged 50 years obtained from CPRD-HES in the same calendar year [37], we noted a several 100-fold higher rate of pertussis infections based on seroprevalence. This emphasizes the high circulation of B. pertussis in patients with COPD in England, but also that one should take into account the difficulty in distinguishing increased cough without fever due to pertussis infection from other triggers provoking a worsening of the clinical condition in patients with chronic cough.…”

Section: Discussionmentioning

confidence: 92%

“…To this end, the proportion of patients in the AERIS cohort subset with samples taken in 2013 who had an anti-PT 70 IU/mL (indicative of B. pertussis infection within the last 12 months) at M12 or M24 was compared with (i.e. divided by) the reported incidence rate in 2013 in patients 50 years old with COPD obtained from the Clinical Practice Research Datalink (CPRD) linked to the Hospital Episode Statistics (HES) database from a separate study [37].…”

Section: Exploratory Analysesmentioning

confidence: 99%

“…The reported pertussis disease incidence rate in a COPD cohort aged 50 years in the CPRD-HES database ranged between 3.15 and 10.95 per 100 000 person-years follow-up between 2011 and 2018, and was 5.38 per 100 000 personyears follow-up (95% CI, 2.46-10.21) in 2013 [37]. Pertussis is a notifiable disease in England [30], and in 2013, 98.7% of confirmed pertussis cases in individuals >15 years of age were reported to Public Health England based on serology testing with a threshold of 70 IU/mL [30,40].…”

Section: Comparison Of Pertussis Infection With Reported Clinical Casesmentioning

confidence: 99%

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Seroprevalence ofBordetella pertussisInfection in Patients With Chronic Obstructive Pulmonary Disease in England: Analysis of the AERIS Cohort

Wilkinson

Steen

Cheuvart

et al. 2021

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Pertussis is underdiagnosed and underreported in adults and patients with underlying conditions. Patients with chronic obstructive pulmonary disease (COPD) may be at increased risk of severe pertussis. Understanding the true prevalence of pertussis infections in such patients is important. We therefore evaluated the seroprevalence of anti-pertussis toxin (PT) antibodies in a cohort of 40-85-year-old patients diagnosed with moderate, severe or very severe COPD enrolled (between June 2011 and June 2012) in the prospective, observational "Acute Exacerbation and Respiratory InfectionS in COPD" (AERIS; NCT01360398) study, conducted in England. Serum anti-PT antibodies were measured in 104 patients using an enzyme-linked immunosorbent assay on samples collected 12 months (M12) and 24 months (M24) after enrollment. Overall, 14/104 (13.5%) patients had anti-PT concentrations 50 IU/mL at M12 or M24, indicative of exposure to Bordetella pertussis during the preceding 2-3 years. Of these, 6/104 (5.8%) had anti-PT 70 IU/mL, of whom 3/104 (2.9%) had anti-PT 120 IU/mL, indicative of exposure within 12 and 6 months, respectively. These results show a high circulation of B. pertussis in 40-85-year-old patients with moderate, severe or very severe COPD in England between 2012 and 2014, and call for enhanced immunization to prevent pertussis infections in such patients.

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Late Breaking Abstract - Burden of pertussis in COPD: a retrospective database study in England

Cited by 2 publications

References 0 publications

Burden of Pertussis in COPD: A Retrospective Database Study in England

Burden of Pertussis in COPD: A Retrospective Database Study in England

Seroprevalence ofBordetella pertussisInfection in Patients With Chronic Obstructive Pulmonary Disease in England: Analysis of the AERIS Cohort

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