“…1,3 Other important factors include the type and size of the catheter, the angle of the catheter relative to the vessel wall, the osmolarity of the fluid being infused, and anatomical variations. 1,3,6 Mechanisms postulated to contribute to perforations include erosion of the myocardial wall from catheter malposition, catheter migration, and direct trauma during CVC. 3,11 Failure to consider cardiac and vascular wall perforations as differentials in cases of sudden clinical deterioration could lead to serious clinical sequelae, including death.…”