Late and very‐late first‐contact schizophrenia and the risk of dementia–a nationwide register based study

Kørner, Alex; López, Ana García; Lauritzen, L.; Andersen, Per Kragh; Kessing, Lars Vedel

doi:10.1002/gps.2075

Cited by 66 publications

(82 citation statements)

References 14 publications

(25 reference statements)

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“…Similarly, the debate on whether early-life or late-life depression is more important risk factor is ongoing (3,6,(8)(9)(10)(11)(12)(13). The results of studies investigating the association between bipolar disorder and dementia (14)(15)(16)(17) and late-life schizophrenia and dementia (18)(19)(20)(21) have been equally heterogeneous.…”

Section: Introductionmentioning

confidence: 99%

Hospital-treated mental and behavioral disorders and risk of Alzheimer's disease: A nationwide nested case-control study

et al. 2017

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ArtikkelitTerveystieteiden Conflicts of Interest and Source of FundingVesa Tapiainen, Sirpa Hartikainen, Heidi Taipale and Anna-Maija Tolppanen report no competing interests. Jari Tiihonen reports serving as a consultant to AstraZeneca, Bristol-Myers Squibb, Eli Lilly, F. Hoffman-La Roche, Janssen-Cilag, Lundbeck, and Organon. He has received fees for giving expert opinions to AstraZeneca, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen-Cilag, Lundbeck, Otsuka and Pfizer, and lecture fees from AstraZeneca, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen-Cilag, Lundbeck, Novartis, Otsuka, and Pfizer; and grant from Stanley Foundation and Sigrid Jusélius Foundation. He is a member of advisory board in AstraZeneca, Eli Lilly, Janssen-Cilag, and Otsuka.This work was supported by European Regional Development Fund (Regional Council of Pohjois-Savo) [32198 to Vesa Tapiainen, Heidi Taipale and Anna-Maija Tolppanen]. The funder had no role in study design; in the collection, analysis, and interpretation of data, in the writing of the report; and in the decision to submit the paper for publication. Conclusions:The associations between mental and behavioral disorders and AD were modest and dependent on the time window. Therefore, some of the disorders may represent misdiagnosed prodromal symptoms of AD which underlines the importance of proper differential diagnostics among older persons. These findings also highlight the importance of appropriate time window in psychiatric and neuroepidemiology research.

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Section: Introductionmentioning

confidence: 99%

Hospital-treated mental and behavioral disorders and risk of Alzheimer's disease: A nationwide nested case-control study

et al. 2017

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“…after age 40 years) were at increased risk of dementia [20-22]. The Danish study reported a 2.4-fold increased risk of dementia after almost 5-years of follow-up in 1,206 late-onset schizophrenia patients when compared to normal controls [20].…”

Section: Introductionmentioning

confidence: 99%

Severe Psychiatric Disorders in Mid-Life and Risk of Dementia in Late- Life (Age 65-84 Years): A Population Based Case-Control Study

Zilkens¹,

Bruce²,

Duke³

et al. 2014

CAR

108

126

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Objective: To examine the association of mid-life exposure to several psychiatric disorders with the development of late-life dementia. Methods: A matched case-control study using Western Australian state-wide hospital inpatient, outpatient mental health and emergency records linked to death records. Incident dementia cases (2000-2009) aged 65 to 84 years were sex- and age-matched to an electoral roll control. Records as far back as 1970 were used to assess exposure to medical risk factors before age 65 years. Candidate psychiatric risk factors were required to be present at least 10 years before dementia onset to ensure direction of potential causality. Odds ratios were estimated using conditional logistic regression. Results: 13, 568 dementia cases (median age 78.7 years, 43.4% male) were matched to a control. Depression, bipolar disorder, schizophrenia, anxiety disorder and alcohol dependence were found to be significant and independent risk factors for late-life dementia after adjusting for diabetes, heart disease, cerebrovascular disease and smoking risk factors. The effect of a history of depression, schizophrenia and alcohol dependency on dementia risk varied with age, being strongest for earlier onset late-life dementia and waning at older ages. Conclusion: Severe depression, anxiety disorder, bipolar disorder, schizophrenia and alcoholic dependency disorder treated by specialists in psychiatric facilities in mid-life are important risk factors for late-life dementia. These psychiatric conditions need to be considered in future studies of the risk and prevention of late-life dementia.

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“…33 In Danish register data study, patients with late-onset schizophrenia (first-contact over age 40) and very-late-onset schizophrenia (first contact over age 60) were both 3-times more likely to develop dementia than patients with osteoarthritis, and twice more likely to develop dementia than a gender-and age-matched sample of the general population over a median follow-up period of 3-4 years. 61 Another study, based on the same registry approach, showed that patients with very-lateonset delusional disorder were 8-times more likely to develop dementia (15.2% versus 2.1%) compared to those with osteoarthritis over a median follow-up period of approximately 2 and 4 years, respectively. 60 Compared to age-, gender-, and calendar-matched general population, very-late-onset delusional disorder were 5-times more likely to develop dementia.…”

Section: Is Late-onset Psychosis a Prodromal Symptom Of Dementia?mentioning

confidence: 99%

“…A certain cutoff Mini-Mental State Examination (MMSE) score or similar neuropsychological test score for inclusion used in many studies have not been strictly comparable. Some studies excluded patients only on the basis of a clinical diagnosis of dementia, 58,60,61,97 while another study did not use any specific exclusion criteria regarding cognitive status. 46 Considering the lack of standardized and validated study design, it is not surprising that cognitive cut-off scores adopted in study populations varied from a MMSE score of 17.6 46 to 28.21.…”

Section: Is Late-onset Psychosis a Prodromal Symptom Of Dementia?mentioning

confidence: 99%

Late-Onset Psychosis; Is It Real?

Kwak

Yang

Koo

2015

Dement Neurocognitive Disord

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The nature of late-onset psychosis in the absence of a dementia or secondary to organic dysfunctions in the fifth decade of life and beyond is contentious and unresolved. Different terminologies, diagnostic criteria and age cut-offs have been applied to late-onset psychosis, which have stymied clinicians and researchers. No official diagnostic designation for patients with late-onset psychosis is included in the current psychiatric diagnostic system (Diagnostic and Statistical Manual of Mental Disorders-V, International Classification of Diseases-10). The validity of this diagnostic exclusion has been questioned. Despite these problems, a relatively consistent clinical picture has reported. However, many questions remain regarding the underlying etiology, pathophysiological mechanisms, treatment and prognosis. Whether late-onset psychosis is distinct from schizophrenia and whether it might be a harbinger of dementia are unclear. Recent studies have suggested an underlying biological pathophysiology of late-onset psychosis.

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Late and very‐late first‐contact schizophrenia and the risk of dementia–a nationwide register based study

Abstract: schizophrenic patients with late- and very-late first-contact with the psychiatric hospital system are at two to three times higher risk of subsequently getting a diagnosis of dementia compared to patients with osteoarthritis and compared to the general population.

Cited by 66 publications

References 14 publications

Hospital-treated mental and behavioral disorders and risk of Alzheimer's disease: A nationwide nested case-control study

Hospital-treated mental and behavioral disorders and risk of Alzheimer's disease: A nationwide nested case-control study

Severe Psychiatric Disorders in Mid-Life and Risk of Dementia in Late- Life (Age 65-84 Years): A Population Based Case-Control Study

Late-Onset Psychosis; Is It Real?

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