Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene

Roth, Tania L.; Lubin, Farah D.; Funk, Adam; Sweatt, J. David

doi:10.1016/j.biopsych.2008.11.028

Cited by 1,109 publications

(1,121 citation statements)

References 75 publications

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“…1). Similarly, risks related to undernutrition, obesity, substance abuse and mental disorders become prominent following puberty and tend to persist through the transition to parenthood even when this occurs decades later 84 .…”

Section: Persistence Of Adolescent Assets and Risksmentioning

confidence: 99%

Adolescence and the next generation

Patton

Olsson

Skirbekk

et al. 2018

Nature

259

204

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Adolescent growth and social development shape the early development of offspring from preconception through to the post-partum period through distinct processes in males and females. At a time of great change in the forces shaping adolescence, including the timing of parenthood, investments in today’s adolescents, the largest cohort in human history, will yield great dividends for future generations.

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Section: Persistence Of Adolescent Assets and Risksmentioning

confidence: 99%

Adolescence and the next generation

Patton

Olsson

Skirbekk

et al. 2018

Nature

259

204

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“…Rats reared (and subsequently housed) on corncob bedding exhibited signicantly less-anxious phenotypes compared to those reared (then housed) on wood pulp bedding material. As glucocorticoid receptor, BDNF, CRH, CRH-R1, and CRH-R2 expression (in various neuronal regions) have all been implicated in the expression of fear and anxiety and are sensitive to early life environmental factors, we wished to assess if bedding conditions during early life inuenced the expression of these genes [11,31,[41][42][43]. Hypothalamic CRH, CRH-R1, and CRH-R2 mRNA levels were not signicantly different across conditions.…”

Section: Discussionmentioning

confidence: 99%

Influence of housing variables on the development of stress-sensitive behaviors in the rat

Sakhai

Preslik

Francis

2013

Physiology & Behavior

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• Laboratory bedding material inuences developmental programming of rats.• Bedding material during early life can alter stress sensitive measures in adulthood.• Corncob bedding during sensitive periods decreases adult measures of anxiety.• Bedding material during adulthood does not affect adult anxiety-like behavior. Diverse environments early in mammalian life can have profound inuences on the physiology and behavior of developing offspring. Environmental factors can inuence offspring development directly or through perturbations in parental care. In the current study, we wished to determine if the inuence of a single environmental variable, type of bedding material used in laboratory cages, is capable of altering physiological and behavioral outcomes in offspring. Female rats were housed in cages containing wood pulp or corncob bedding and allowed to mature. These rats, while housed on assigned bedding material, were bred and allowed to give birth. At weaning, male offspring were housed on one of the two bedding conditions and tested later in adulthood on stress-sensitive behavioral measures. Postmortem analysis of glucocorticoid receptor expression and CRH mRNA levels were also measured. Maternal care directed at the pups reared in the two different bedding conditions was also recorded. Rats reared from birth on corncob bedding exhibited decreased anxiety-like behavior, as adults, in both open eld and light-dark box tasks compared to wood pulp reared animals. Animals that received similar overall levels of maternal care, regardless of bedding condition, also differed in anxiety-like behaviors as adults, indicating that the bedding condition is capable of altering phenotype independent of maternal care. Despite observed behavioral differences in adult offspring reared in different bedding conditions, no changes in glucocorticoid receptor expression at the level of the hippocampus, frontal cortex, or corticotrophin releasing hormone (CRH) mRNA expression in the hypothalamus were observed between groups. These results highlight the importance of early life housing variables in programming stress-sensitive behaviors in adult offspring. a b s t r a c t a r t i c l e i n f oPublished by Elsevier Inc.

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“…Variations in pup LG in the rat directly affect the development of behavioral and hypothalamic-pituitary-adrenal (HPA) responses to stress in adulthood [25][26][27][28][29][30][31][32][33]. Rat mothers exhibit considerable naturallyoccurring variations in the frequency of pup LG over the first week A schema outlining the function of the hypothalamic-pituitary-adrenal axis, the nexus of which are the corticotropin-releasing factor (CRF) neurons of the paraventricular nucleus of the hypothalamus.…”

Section: Parental Effects On Stress Responsesmentioning

confidence: 99%

Environmental regulation of the neural epigenome

et al. 2011

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a b s t r a c tParental effects are a major source of phenotypic plasticity. Moreover, there is evidence from studies with a wide range of species that the relevant parental signals are influenced by the quality of the parental environment. The link between the quality of the environment and the nature of the parental signal is consistent with the idea that parental effects, whether direct or indirect, might serve to influence the phenotype of the offspring in a manner that is consistent with the prevailing environmental demands. In this review we explore recent studies from the field of 'environmental epigenetics' that suggest that (1) DNA methylation states are far more variable than once thought and that, at least within specific regions of the genome, there is evidence for both demethylation and remethylation in post-mitotic cells and (2) that such remodeling of DNA methylation can occur in response to environmentally-driven, intracellular signaling pathways. Thus, studies of variation in mother-offspring interactions in rodents suggest that parental signals operate during pre-and/ or post-natal life to influence the DNA methylation state at specific regions of the genome leading to sustained changes in gene expression and function. We suggest that DNA methylation is a candidate mechanism for parental effects on phenotypic variation.

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Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene

Cited by 1,109 publications

References 75 publications

Adolescence and the next generation

Adolescence and the next generation

Influence of housing variables on the development of stress-sensitive behaviors in the rat

Environmental regulation of the neural epigenome

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