Last Decade of Unconventional Methodologies for the Synthesis of Substituted Benzofurans

Abstract

This review describes the progress of the last decade on the synthesis of substituted benzofurans, which are useful scaffolds for the synthesis of numerous natural products and pharmaceuticals. In particular, new intramolecular and intermolecular C–C and/or C–O bond-forming processes, with transition-metal catalysis or metal-free are summarized. (1) Introduction. (2) Ring generation via intramolecular cyclization. (2.1) C7a–O bond formation: (route a). (2.2) O–C2 bond formation: (route b). (2.3) C2–C3 bond formation: (route c). (2.4) C3–C3a bond formation: (route d). (3) Ring generation via intermolecular cyclization. (3.1) C7a-O and C3–C3a bond formation (route a + d). (3.2) O–C2 and C2–C3 bond formation: (route b + c). (3.3) O–C2 and C3–C3a bond formation: (route b + d). (4) Benzannulation. (5) Conclusion.

Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes

“…Hence, the main synthetic task was developing a suitable cross-coupling method introducing the desired residues in position five of building block II and subsequent elaboration of the olefin function towards the substituents identified for the naturally occurring compounds. Naturally, there are many ways to synthesize substituted benzofurans [ 11 ], and also the type of structure we are aiming for has been synthesized previously. For example, Duan et al used a strategy in which the benzofuran core was constructed individually for each derivative synthesized [ 12 ].…”

Clarification on the Reactivity of Diaryl Diselenides toward Hexacyclohexyldilead under Light

“…Organochalcogen compounds are widely used as functional materials and pharmaceuticals [ 1 , 2 ]. These functional molecules are mainly synthesized using ionic and metal-assisted reactions [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. To develop new functional molecules that will support future society, conventional synthetic methods alone are insufficient.…”

2,2-Bis(phenylselanyl)-1-(p-tolyl)vinyl 2-Oxo-2-(p-tolyl)acetate

“…Atomically efficient and selective addition reaction of heteroatom compounds to car-boncarbon unsaturated bonds is one of the most valuable synthetic reactions [1][2][3][4][5][6][7][8][9][10][11][12]. The addition of heteroatom compounds to alkynes affords the corresponding alkenyl heteroatoms, which are typically present not only in synthetic intermediates but also in a variety of natural products and functional molecules [13][14][15][16][17][18].…”