Lasing in blood

Chen, Yu Cheng; Chen, Qiushu; Fan, Xudong

doi:10.1364/optica.3.000809

Cited by 93 publications

(96 citation statements)

References 52 publications

(72 reference statements)

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“…Lasing in blood was as efficient as in water, meaning that the red blood cells and other constituents of blood did not frustrate lasing. Bio-lasers in blood could enable to diagnosis performed directly in blood [27]. …”

Section: Resultsmentioning

confidence: 99%

Biomaterial microlasers implantable in the cornea, skin, and blood

Humar

Dobravec

Zhao

et al. 2017

Optica

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Stand-alone laser particles that are implantable into biological tissues have potential to enable novel optical imaging, diagnosis and therapy. Here we demonstrate several types of biocompatible microlasers and their lasing action within biological systems. Dye-doped polystyrene beads were embedded in the cornea and optically pumped to generate narrowband emission. We fabricated microbeads with poly(lactic-co-glycolic acid) and poly(lactic acid)—substances approved for medical use—and demonstrate lasing from within tissues and whole blood. Furthermore, we demonstrate biocompatible cholesterol-derivative microdroplet lasers via self-assembly to an onion-like radially-resonant photonic crystal structure.

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Section: Resultsmentioning

confidence: 99%

Biomaterial microlasers implantable in the cornea, skin, and blood

Humar

Dobravec

Zhao

et al. 2017

Optica

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“…Most recently, the use of green fluorescent proteins within a single cell embedded in an external microcavity was shown to create lasing action while keeping the cell alive [26], and lasing in blood was also shown [27]. The latter example is illustrated in Figure 1B.…”

Section: Reconfigurable Optofluidic Devices and Systemsmentioning

confidence: 99%

“…(B) Left: schematic view of optically pumped “blood laser” realized in OFRR illustrating components in serum (GLB, globulins; HAS, human serum albumin; ICG, active dye medium; WBC, white blood cells); right: corresponding L-I curve under optical pumping (after [27]).…”

Section: Figurementioning

confidence: 99%

Optofluidic bioanalysis: fundamentals and applications

et al. 2017

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Over the past decade, optofluidics has established itself as a new and dynamic research field for exciting developments at the interface of photonics, microfluidics, and the life sciences. The strong desire for developing miniaturized bioanalytic devices and instruments, in particular, has led to novel and powerful approaches to integrating optical elements and biological fluids on the same chip-scale system. Here, we review the state-of-the-art in optofluidic research with emphasis on applications in bioanalysis and a focus on waveguide-based approaches that represent the most advanced level of integration between optics and fluidics. We discuss recent work in photonically reconfigurable devices and various application areas. We show how optofluidic approaches have been pushing the performance limits in bioanalysis, e.g. in terms of sensitivity and portability, satisfying many of the key requirements for point-of-care devices. This illustrates how the requirements for bianalysis instruments are increasingly being met by the symbiotic integration of novel photonic capabilities in a miniaturized system.

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“…Microlasers have emerged as a promising technology, garnering a tremendous amount of attention owing to its potential for use in biomedical and biological applications . Various types of optical microcavities have been developed, such as Fabry–Perot cavities, photonic crystals, and whispering‐gallery‐modes (WGMs), as implemented in ring resonators, micro‐/nanodisks, and microspheres . In particular, microsphere‐based WGM lasers are appealing candidates for sensing probes owing to their convenience, extremely high Q factor, and potential for application in intracellular and extracellular probes .…”

Section: Introductionmentioning

confidence: 99%

Lasing‐Encoded Microsensor Driven by Interfacial Cavity Resonance Energy Transfer

Yuan

Wang

Guan

et al. 2020

Advanced Optical Materials

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for use in biomedical and biological applications. [1][2][3][4][5] Various types of optical microcavities have been developed, such as Fabry-Perot cavities, [6][7][8] photonic crystals, [9] and whispering-gallery-modes (WGMs), as implemented in ring resonators, [10][11][12] micro-/nanodisks, [13,14] and microspheres. [3][4][5][15][16][17][18][19][20] In particular, microsphere-based WGM lasers are appealing candidates for sensing probes owing to their convenience, extremely high Q factor, and potential for application in intracellular and extracellular probes. [13,15,16,21,22] Moreover, analytes can be positioned outside of the optical cavity, where an evanescent field exists at the external interface between the resonant cavity and surrounding medium. [23][24][25] At present, most microsphere or droplet-based WGM lasers are considered to be passive-detection devices, as they require physical changes (e.g., refractive indexes) to induce a resonance spectral shift, and thus cannot provide detailed biochemical information. [26][27][28] In contrast, active-detection devices, which employ analytes as the gain medium, can provide more selective and sensitive information about the biospecies. [8,29] Therefore, the ability to utilize a biological gain medium on the external surface of a microsphere cavity will allow us to amplify subtle changes in the gain medium and the resultant spectra, threshold, and lasing modes. However, the overlap factor for the optical mode and gain medium is much lower than the value of the gain within the cavity, and the background fluorescence also interferes with the external cavity sensing, making this amplification a difficult task. Thus, to enable amplification of these subtle changes, we have applied the concept of Förster resonance energy transfer (FRET) at the interface of a droplet-based laser to separate the donor and acceptor at the droplet-surface interface (Figure 1a). FRET is an electrodynamic phenomenon that is highly sensitive to distance, spectral overlap, and the orientation between donor and acceptor molecules. In the past decade, FRET has been used as a powerful tool for providing nanoscale information in many biosensing applications. The performance of FRET is mainly dependent on the design of the donor and acceptor pairs. Several groups recently utilized FRET by using donor molecules as exciton funnels, [30,31] or light-harvesting antennas, [31] to realize a wavelength tunable laser, [30] single molecule nanoprobes, [32] or light redirectioning devices [33] that strongly amplify the emission of acceptor molecules when Microlasers are emerging tools for biomedical applications. In particular, whispering-gallery-mode (WGM) microlasers are promising candidates for sensing at the biointerface owing to their high quality-factor and potential in molecular assays, and intracellular and extracellular detection. However, lasing particles with sensing functionality remain challenging since the overlap between the WGM optical mode and external gain medium is much lower compared to ...

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Lasing in blood

Cited by 93 publications

References 52 publications

Biomaterial microlasers implantable in the cornea, skin, and blood

Biomaterial microlasers implantable in the cornea, skin, and blood

Optofluidic bioanalysis: fundamentals and applications

Lasing‐Encoded Microsensor Driven by Interfacial Cavity Resonance Energy Transfer

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