Laserthermia on Head and Neck Malignancies— Experimental and Clinical Studies

Ohyama, Masaru; Nobori, Takuo; Moriyama, Ichiro; Furuta, Shigeru; Shima, Tetsuya

doi:10.3109/00016488809125094

Cited by 14 publications

(7 citation statements)

References 9 publications

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“…ILTT is based on interstitial tissue destruction by means of laser coagulation as well as hyperthermia and was described first by Bown in 1983 [7]. Since then several experimental and clinical studies in liver [37], pancreas [14], prostate [40], head and neck [26] and brain have been performed [31,39]. The purpose of this article is to present the current status of ILTT for the treatment of intracranial tumours, to discuss its possibilities in neurosurgery, and to suggest possible improvements.…”

Section: Introductionmentioning

confidence: 99%

Interstitial laser thermotherapy in neurosurgery: A review

et al. 1996

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One of the most recent laser treatment modalities in neurosurgery is interstitial laser thermotherapy (ILTT). In this review, experimental and clinical studies concerning intracranial ILTT are discussed. Two methods for intra-operative control of the laser induced lesions are described; i.e., computer-controlled power delivery, using a thermocouple that is positioned interstitially at the periphery of the tumour to maintain the desired temperature at that point, and MRI, to visualise the extent of the thermal lesions induced by ILTT. The results show that ILTT using a Nd: YAG laser is easy and relatively effective in the treatment of small deep-seated brain tumours with minimal risk and complications. This review is concluded with suggestions for further improvement of this treatment modality.

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Section: Introductionmentioning

confidence: 99%

Interstitial laser thermotherapy in neurosurgery: A review

et al. 1996

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“…The Nd:YAG laser operating at 1,064 nm has generally been preferred since there is relatively good light penetration in soft tissues at this wavelength [61. While still experimental, ILP has been used both interstitially and in contact mode to treat unresectable localized human tumors in brain 171, head and neck [8,9], liver, breast, and pancreas [lo-121. Most of the experimental work has involved assessing safety and efficacy using animal models [2,3, and determining appropriate technical parameters [18-211. A central problem in interstitial heating is that the size and geometry of thermal lesions are difficult to predict due to the variability of blood flow in living tissues.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging of interstitial laser photocoagulation in brain

et al. 1992

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Magnetic resonance (MR) imaging can be used to monitor the development of thermal lesions induced in tissue using interstitial laser photocoagulation (ILP). A potential application for ILP is the treatment of surgically inaccessible brain tumors. For the successful clinical application of MR-monitored ILP, it is necessary to relate MR images of ILP lesions to the actual induced lesions. In this preliminary study we performed ILP in the normal brains of anesthetized cats by delivering interstitially 1.0, 1.5, and 2.0 W of continuous-wave Nd:YAG laser energy (1,064 nm) for 1,000 s via a plane-cut 400 microns core optical fiber. At 48 h post-irradiation the lesions consisted of four sharply demarcated concentric zones of thermal damage. Lesion diameter increased linearly with delivered power. T2-weighted proton spin-echo images acquired during ILP showed a region of complete or near signal loss that underestimated the actual lesion at 48 h. Gadolinium-enhanced T1-weighted spin-echo images acquired immediately post-irradiation showed the actual lesion precisely.

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“…3 Furthermore, hyperthermia has been shown to reduce blood flow at the heated area around the probe while increasing blood flow at the margin. 4 Increased blood flow at the margin of hyperthermia may increase the concentration of chemotherapeutic agents and tissue oxygen, thus enhancing the antitumor effect of chemotherapy or radiation when combined with hyperthermia.…”

Section: Discussionmentioning

confidence: 99%

Multidisciplinary treatment, including laser hyperthermia, for extensive regional metastasis of a penile tumor

Shirahama¹,

Enokida²,

Yanase³

et al. 1999

Int J of Urology

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Background: There is no reliable treatment for penile tumor with lymph node metastasis. Methods: We report on a patient with a penile tumor with extensive regional metastasis that was successfully managed with combined laser hyperthermia, radiation and chemotherapy. Results:The patient has survived more than 7 years without evidence of disease. Conclusions: Multidisciplinary treatment, including laser hyperthermia, may be useful for the treatment of regional metastasis of penile tumor.

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Laserthermia on Head and Neck Malignancies— Experimental and Clinical Studies

Cited by 14 publications

References 9 publications

Interstitial laser thermotherapy in neurosurgery: A review

Interstitial laser thermotherapy in neurosurgery: A review

Magnetic resonance imaging of interstitial laser photocoagulation in brain

Multidisciplinary treatment, including laser hyperthermia, for extensive regional metastasis of a penile tumor

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