Laserbehandlung von Pigmentstörungen

Fritz, Klaus; Sălăvăstru, Carmen

doi:10.1007/s00105-020-04716-x

Cited by 5 publications

(1 citation statement)

References 41 publications

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“…The optimal treatment would be one of a multifactorial action, such as a combination therapy in which topical treatment would inhibit the production of melanin and the transfer of melanosomes to keratinocytes and the laser or light-based treatment would accelerate the removal of melanin. It is worth mentioning that laser therapy and light therapy can also be used effectively in other diseases and conditions with hyperpigmentation [177][178][179].…”

Section: Laser Therapymentioning

confidence: 99%

Understanding Melasma-How Can Pharmacology and Cosmetology Procedures and Prevention Help to Achieve Optimal Treatment Results? A Narrative Review

Piętowska

Nowicka

Szepietowski

2022

IJERPH

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Melasma is a chronic skin condition that involves the overproduction of melanin in areas exposed to ultraviolet radiation. Melasma treatment is long-term and complicated with recurrence and resistance to treatment. The pathogenesis of melasma is highly complex with multiple pathologies occurring outside of the skin pigment cells. It includes photoaging, excessive melanogenesis, an increased number of mast cells, increased vascularization, and basement membrane damage. In addition, skin lesions related to melasma and their surrounding skin have nearly 300 genes differentially expressed from healthy skin. Traditionally, melasma was treated with topical agents, including hydroquinone, tretinoin, glucocorticosteroids and various formulations; however, the current approach includes the topical application of a variety of substances, chemical peels, laser and light treatments, mesotherapy, microneedling and/or the use of systemic therapy. The treatment plan for patients with melasma begins with the elimination of risk factors, strict protection against ultraviolet radiation, and the topical use of lightening agents. Hyperpigmentation treatment alone can be ineffective unless combined with regenerative methods and photoprotection. In this review, we show that in-depth knowledge associated with proper communication and the establishment of a relationship with the patient help to achieve good adherence and compliance in this long-term, time-consuming and difficult procedure.

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Section: Laser Therapymentioning

confidence: 99%