Laser-triggered drug release from polymeric 3-D micro-structured films via optical fibers

Kurochkin, Maxim A.; Sindeeva, Olga A.; Brodovskaya, Ekaterina P.; Gai, Meiyu; Frueh, Johannes; Su, Lei; Sapelkin, Andrei V.; Tuchin, Valery V.; Sukhorukov, Gleb B.

doi:10.1016/j.msec.2020.110664

Cited by 15 publications

(9 citation statements)

References 70 publications

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“…Microchamber arrays are suitable for loading a wide range of both poorly and well-water-soluble substances with low [ 34 , 36 ] and high [ 37 , 38 ] molecular weight. Such coatings have been demonstrated to be sensitive to ultrasound [ 33 , 34 ] and NIR-laser radiation [ 39 ] after shells were modified with photo adsorbent agents such as gold coating [ 40 , 41 ] or nanoparticles [ 37 ] and carbon dots aggregates [ 38 , 42 ]. The site-specific laser-induced release of glutamate hydrochloride stimulated the response from neuronal-type cells (N2A) located near the open chambers [ 36 ], controlled nerve growth factor release stimulated the growth and proliferation [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Patterned Drug-Eluting Coatings for Tracheal Stents Based on PLA, PLGA, and PCL for the Granulation Formation Reduction: In Vivo Studies

et al. 2021

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Expandable metallic stent placement is often the only way to treat airway obstructions. Such treatment with an uncoated stent causes granulation proliferation and subsequent restenosis, resulting in the procedure’s adverse complications. Systemic administration of steroids drugs in high dosages slows down granulation tissue overgrowth but leads to long-term side effects. Drug-eluting coatings have been used widely in cardiology for many years to suppress local granulation and reduce the organism’s systemic load. Still, so far, there are no available analogs for the trachea. Here, we demonstrate that PLA-, PCL- and PLGA-based films with arrays of microchambers to accommodate therapeutic substances can be used as a drug-eluting coating through securely fixing on the surface of an expandable nitinol stent. PCL and PLA were most resistant to mechanical damage associated with packing in delivery devices and making it possible to keep high-molecular-weight cargo. Low-molecular-weight methylprednisolone sodium succinate is poorly retained in PCL- and PLGA-based microchambers after immersion in deionized water (only 9.5% and 15.7% are left, respectively). In comparison, PLA-based microchambers retain 96.3% after the same procedure. In vivo studies on rabbits have shown that effective granulation tissue suppression is achieved when PLA and PLGA are used for coatings. PLGA-based microchamber coating almost completely degrades in 10 days in the trachea, while PLA-based microchamber films partially preserve their structure. The PCL-based film coating is most stable over time, which probably causes blocking the outflow of fluid from the tracheal mucosa and the aggravation of the inflammatory process against the background of low drug concentration. Combination and variability of polymers in the fabrication of films with microchambers to retain therapeutic compounds are suggested as a novel type of drug-eluting coating.

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Section: Introductionmentioning

confidence: 99%

Patterned Drug-Eluting Coatings for Tracheal Stents Based on PLA, PLGA, and PCL for the Granulation Formation Reduction: In Vivo Studies

et al. 2021

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“…Polymers have been widely used as biomaterials for the manufacture of medical devices as well as tissue engineering platforms. In particular, hydrogels have aroused great interest in biomedicine, mainly focusing on the development of scaffolds that release therapeutic agents [73][74][75][76]. In this context, hydrogels based on natural polymers have been extensively studied for applications in biomedicine due to their intrinsic characteristics of biocompatibility, biodegradability, and similarities to the extracellular matrix [45,[77][78][79].…”

Section: Advantages Of Polyhy In Controlled Drug Distributionmentioning

confidence: 99%

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

2020

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In recent years, polymeric hydrogels (PolyHy) have been extensively explored for their applications in biomedicine as biosensors, in tissue engineering, diagnostic processes, and drug release. The physical and chemical properties of PolyHy indicate their potential use in regulating drug delivery. Calcineurin inhibitors, particularly cyclosporine (CsA) and tacrolimus (TAC), are two important immunosuppressor drugs prescribed upon solid organ transplants. Although these drugs have been used since the 1970s to significantly increase the survival of transplanted organs, there are concerns regarding their undesirable side effects, primarily due to their highly variable concentrations. In fact, calcineurin inhibitors lead to acute and chronic toxicities that primarily cause adverse effects such as hypertension and nephrotoxicity. It is suggested from the evidence that the encapsulation of calcineurin inhibitors into PolyHy based on polysaccharides, specifically alginate (Alg), offers effective drug delivery with a stable immunosuppressive response at the in vitro and in vivo levels. This not only may reduce the adverse effects but also would improve the adherence of the patients by the effective preservation of drug concentrations in the therapeutic ranges.

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“…MCAs are suitable for carrying a wide range of substances with different molecular weights, in particular, enzymes [30], polysaccharides [36], fluorescent dyes [37], neurotransmitters [34], hormones [31,32], and growth factors [35]. The studies have shown that polymer film with MCAs is sensitive to external stimuli such as ultrasound [29,30,32,38], magnetic field [39], and laser irradiation [30,36,40,41] if additional modifiers are used during their fabrication (magnetic nanoparticles and photoabsorbing agents, respectively). The choice of trigger for drug release in real medical practice must exclude a negative effect on drug load and consider material localization.…”

Section: Introductionmentioning

confidence: 99%

“Smart” Polylactic Acid Films with Ceftriaxone Loaded Microchamber Arrays for Personalized Antibiotic Therapy

et al. 2021

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Bacterial infections are a severe medical problem, especially in traumatology, orthopedics, and surgery. The local use of antibiotics-elution materials has made it possible to increase the effectiveness of acute infections treatment. However, the infection prevention problem remains unresolved. Here, we demonstrate the fabrication of polylactic acid (PLA) “smart” films with microchamber arrays. These microchambers contain ceftriaxone as a payload in concentrations ranging from 12 ± 1 μg/cm2 to 38 ± 8 μg/cm2, depending on the patterned film thickness formed by the different PLA concentrations in chloroform. In addition, the release profile of the antibiotic can be prolonged up to 72 h in saline. At the same time, on the surface of agar plates, the antibiotic release time increases up to 96 h, which has been confirmed by the growth suppression of the Staphylococcus aureus bacteria. The efficient loading and optimal release rate are obtained for patterned films formed by the 1.5 wt % PLA in chloroform. The films produced from 1.5 and 2 wt % PLA solutions (thickness—0.42 ± 0.12 and 0.68 ± 0.16 µm, respectively) show an accelerated ceftriaxone release upon the trigger of the therapeutic ultrasound, which impacted as an expansion of the bacterial growth inhibition zone around the samples. Combining prolonged drug elution with the on-demand release ability of large cargo amount opens up new approaches for personalized and custom-tunable antibacterial therapy.

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Laser-triggered drug release from polymeric 3-D micro-structured films via optical fibers

Cited by 15 publications

References 70 publications

Patterned Drug-Eluting Coatings for Tracheal Stents Based on PLA, PLGA, and PCL for the Granulation Formation Reduction: In Vivo Studies

Patterned Drug-Eluting Coatings for Tracheal Stents Based on PLA, PLGA, and PCL for the Granulation Formation Reduction: In Vivo Studies

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

“Smart” Polylactic Acid Films with Ceftriaxone Loaded Microchamber Arrays for Personalized Antibiotic Therapy

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