Laser treatment of experimentally induced chronic arthritis

Guerino, M.R; Baranauskas, Vı́tor; Guerino, Adriane Cristina; Parizotto, Nivaldo Antônio

doi:10.1016/s0169-4332(99)00460-2

Cited by 13 publications

(7 citation statements)

References 10 publications

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“…Many reports have showed that LLL relieves pain and stiffness [12], reduce swelling [13], beneficial to improve the limited range of motion (ROM) in human OA [14]. Animal experiments also revealed that the LLL is beneficial to chemically induced OA models in reducing swelling [15], inhibition of inflammation [16], and decreasing destruction of cartilage [17]. Some investigators found that LLL protected the articular cartilage in immobilized rabbit knee [18].…”

Section: Introductionmentioning

confidence: 99%

The effect of low-level laser to apoptosis of chondrocyte and caspases expression, including caspase-8 and caspase-3 in rabbit surgery-induced model of knee osteoarthritis

Lin

Luo

et al. 2010

Rheumatol Int

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The purpose of this study was to observe the effect of 810-nm low-level laser to apoptosis of chondrocyte and related proteins, including caspase-3 and caspase-8, in rabbit surgery-induced model of knee osteoarthritis. A total of 24 New Zealand White rabbits were randomly assigned into 3 groups: test group, model group, and normal group. The rabbits in test group and model group received anterior cruciate ligament transection in the right knee. Six weeks after transection, the rabbits in test group were given 10-session 810-nm laser illumination. Eight weeks after transection, all animal were killed. Modified Mankin Score was made for histological assessment. The caspases expressions and chondrocytes apoptosis were tested using the immunohistochemistry and TUNEL assessment, respectively. The modified Mankin Score of test group was significantly lower than model group (P < 0.01) and higher than normal group (P < 0.01). The caspase-8 expression of test group was lower than model group and higher than normal group, but no significant difference was found (P > 0.05). This study revealed that the 810-nm low-level laser can improve cartilage structure, prevent articular cartilage degradation and significantly decrease the expression of caspase-3 in this surgery-induced OA model. Further studies are needed.

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Section: Introductionmentioning

confidence: 99%

The effect of low-level laser to apoptosis of chondrocyte and caspases expression, including caspase-8 and caspase-3 in rabbit surgery-induced model of knee osteoarthritis

Lin

Luo

et al. 2010

Rheumatol Int

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“…1,12,15,16 Kushibiki et al 15 showed an increased chondrocyte differentiation and higher chondrogenic messenger RNA expression in prechondrogenic cells after laser irradiation. Furthermore, the LLLT is able of reducing swelling, 12 modulating inflammation, 17 decreasing cartilage destruction, 18,19 stimulating angiogenesis, and reducing fibrosis formation 1 in OA animal models. Lin et al 19 demonstrated that 810-nm LLLT can improve cartilage structure, prevent articular cartilage degradation, and significantly decrease the expression of caspase-3 in the knees of the rats submitted to an anterior cruciate ligament transection (ACLT).…”

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confidence: 99%

Effects of phototherapy on cartilage structure and inflammatory markers in an experimental model of osteoarthritis

et al. 2013

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The aim of this study was to evaluate the effects of laser phototherapy on the degenerative modifications on the articular cartilage after the anterior cruciate ligament transection (ACLT) in the knee of rats. Eighty male rats (Wistar) were distributed into four groups: intact control group (IG), injured control group (CG), injured laser treated group at 10 J/cm(2) (L10), and injured laser treated group at 50 J/cm(2) (L50). Animals were distributed into two subgroups, sacrificed in 5 and 8 weeks postsurgery. The ACLT was used to induce knee osteoarthritis in rats. After 2 weeks postsurgery, laser phototherapy initiated and it was performed for 15 and 30 sessions. The histological findings revealed that laser irradiation, especially at 10 J/cm(2), modulated the progression of the degenerative process, showing a better cartilage structure and lower number of condrocytes compared to the other groups. Laser phototherapy was not able to decrease the degenerative process measured by Mankin score and prevent the increase of cartilage thickness related to the degenerative process. Moreover, it did not have any effect in the biomodulation of the expression of markers IL1β, tumor necrosis factor-α, and metalloprotein-13. Furthermore, laser irradiated animals, at 50 J/cm(2) showed a lower amount of collagen type 1.

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“…Vários autores [20][21][22][23][24][25] , verificaram importantes efeitos anti-inflamatórios e analgésicos da terapia laser de baixa potência . A terapia com esse tipo de laser pode ser efetiva, ao mediar os sintomas do processo inflamatório, por meio da estabilização da membrana celular pela normalização das concentrações de cálcio, sódio e potássio, contribuindo com a reparação celular; com a vasodilatação, aumentando o transporte de oxigênio e nutrientes para as células danificadas e facilitando a reparação e remoção dos restos celulares; acelerando a atividade dos leucócitos; aumentando a síntese de prostaglandina em razão da conversão das prostaglandinas PGG2 e PGH2 periosídeos em prostaglandinas PGI2, que possuem ação vasodilatadora e anti-inflamatória, reduzindo a interleucina I, aumentando a resposta dos linfócitos, o que afeta beneficamente toda a resposta linfática, estimulando a angiogênese de capilares linfáticos e sanguíneos por induzir o aumento de Figura 4: Ação do laser na redução do MIP-2.…”

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Terapia com laser 670nm no tratamento da DPOC experimental em ratos

et al. 2010

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Introdução: DPOC é uma enfermidade respiratória com manifestações sistêmicas que se caracteriza pela presença de obstrução crônica do fluxo aéreo, associada a uma resposta inflamatória. Objetivo: Verificar o efeito da laserterapia de laser 670nm, no tratamento da inflamação pulmonar induzida em ratos. Metodologia: 30 ratos foram divididos em três grupos, dos quais dois foram expostos à fumaça de cigarro durante 45 dias e um deles tratados com laser 670nm. Para análise dos resultados foram realizados LBA e ELISA. Resultados: Os resultados foram submetidos à análise de variância (ANOVA), seguida do teste Newman- Keuls para amostras não pareadas. A análise do LBA demonstrou um aumento altamente significativo no número de neutrófilos no grupo DPOC. O grupo tratado, quando comparado ao grupo DPOC, evidenciou uma diminuição significativa no número de neutrófilos. Para o resultado do ELISA, houve queda altamente significativa de TNF-α, quando tratado com laser 670nm, e significativa de MIP-2 e IL-1β. Conclusão: Verifica-se que a ação do laser de 670nm pode atenuar o processo inflamatório induzido.

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Laser treatment of experimentally induced chronic arthritis

Cited by 13 publications

References 10 publications

The effect of low-level laser to apoptosis of chondrocyte and caspases expression, including caspase-8 and caspase-3 in rabbit surgery-induced model of knee osteoarthritis

The effect of low-level laser to apoptosis of chondrocyte and caspases expression, including caspase-8 and caspase-3 in rabbit surgery-induced model of knee osteoarthritis

Effects of phototherapy on cartilage structure and inflammatory markers in an experimental model of osteoarthritis

Terapia com laser 670nm no tratamento da DPOC experimental em ratos

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