Laser treatment of benign melanocytic lesion: a review

Araghi, Farnaz; Ohadi, Laya; Moravvej, Hamideh; Amani, Maliheh; Allameh, Farzad; Dadkhahfar, Sahar

doi:10.1007/s10103-022-03642-9

Cited by 4 publications

(2 citation statements)

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“…Before recommending a therapeutic approach, and laser treatment specifically, it is crucial to consider the location of these pigments within the skin, their types that correspond to separated chromophores, and the pathophysiological processes underlying these pigmentary disorders [ 18 ]. Indeed, the chromophore and location of a particular skin lesion are two parameters that affect which type of laser is most suitable [ 19 ]. As a result, optimal wavelengths with the least amount of hemoglobin or water absorption will target the pigment (typically melanin).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Q-Switched 1064/532 nm Nd:YAG Lasers on Benign Hypermelanosis in Dark-Skinned Individuals—A Preliminary Study

Piccolo,

Fusco,

Crisman

et al. 2024

JCM

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Background: Facial hypermelanosis is a major cosmetic issue that causes severe social embarrassment and psychological pain, particularly among Asians and dark-skinned individuals. Aim: This study assesses the safety and effectiveness of Q-switched 1064/532 nm nanosecond/picosecond lasers in removing benign hypermelanosis in dark-skinned individuals, evaluating the possible associated side effects. Material and methods: A total of 30 participants (80% females and 20% males) with Fitzpatrick skin types IV–V–VI who presented superficial benign hypermelanoses on the facial and décolleté area were enrolled. All patients underwent to one to two laser treatment sessions with a 1064/532 nm Q-switched laser system. Three months after the final laser session, results were assessed by comparing before- and after-treatment photos and using a quartile scale for lesion clearance (4-point Investigator Global Assessment scale). Results: All patients observed global improvements in their pigmented lesions: 53% of patients achieved excellent clearance, 30% of patients achieved good to moderate clearance, 10% of patients achieved slight clearance, and 7% of patients did not respond to the therapy. No serious adverse event occurred. Photos showed the clinical improvement achieved at 3 months follow-up. Conclusions: The Q-switched 1064/532 nm laser proved to be a key tool for treating benign hypermelanosis in all skin types, including dark-skinned persons.

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Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Q-Switched 1064/532 nm Nd:YAG Lasers on Benign Hypermelanosis in Dark-Skinned Individuals—A Preliminary Study

Piccolo,

Fusco,

Crisman

et al. 2024

JCM

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“…The application of lasers in the medical field has undergone substantial expansion, becoming integral components within medical systems and surgical procedures. Laser technology finds diverse applications across various medical domains, encompassing cancer diagnosis [1], cancer therapy [2], dermatology [3], ophthalmology (e.g., Laser Assisted In Situ Keratomileusis laser coagulation, and optical tomography) [4], and prostatectomy. Moreover, lasers play pivotal roles in cosmetic procedures such as unwanted hair removal and tattoo elimination [5].…”

Section: Introductionmentioning

confidence: 99%

Determination of Laser Parameters in Thermomechanical Treatment of Skin Based on Response Surface Methodology

Nazha,

Darwich,

Ammar

et al. 2024

Applied Sciences

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An investigation was conducted to examine the photothermal and thermomechanical effects of short-pulse laser irradiation on normal tissues. This study analyzed the impact of short-pulse laser radiation on the heat-affected region within tissues, taking into consideration a set of laser variables, namely wavelength, intensity, beam size, and exposure time. The beam size ranged between 0.5 and 3 mm, and the intensity of the laser radiation ranged from 1 to 5 W/mm2 at wavelengths of 532 and 800 nm. A three-layered, three-dimensional model was implemented and studied in a polar coordinate system (r = 10 mm, z = 12 mm) in COMSOL Multiphysics (version 5.4, COMSOL Inc., Stockholm, Sweden) to perform numerical simulations. The Pennes bioheat transfer model, Beer-Lambert, and Hooke’s law are integrated to simulate the coupled biophysics problem. Temperature and stress distributions resulting from laser radiation were produced and analyzed. The accuracy of the developed model was qualitatively verified by comparing temperature and mechanical variations following the variations of laser parameters with relevant studies. The results of Box-Behnken analysis showed that beam size (S) had no significant impact on the response variables, with p-values exceeding 0.05. Temperature (Tmax) demonstrates sensitivity to both beam intensity (I) and exposure time (T), jointly contributing to 89.6% of the observed variation. Conversely, while beam size (S) has no significant effect on stress value (Smax), wavelength (W), beam intensity (I), and exposure time (T) collectively account for 71.6% of the observed variation in Smax. It is recommended to use this model to obtain the optimal values of the laser treatment corresponding to tissue with specified dimensions and properties.

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