Laser Therapy for Prevention and Treatment of Pathologic Excessive Scars

Jin, Rui; Huang, Xiaolu; Li, Hua; Yuan, Ye; Li, Bin; Chen, Cheng; Li, Qingfeng

doi:10.1097/prs.0b013e3182a97e43

Cited by 59 publications

(39 citation statements)

References 36 publications

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“…The beneficial effect of LLLT or photobiomodulation therapy in ameliorating fibrosis has been recently demonstrated in different damaged and diseased organs including kidney, skeletal muscle, skin, heart and tendon, but little is known concerning the cellular and molecular mechanisms by which the laser could exert this action .…”

Section: Discussionmentioning

confidence: 99%

Low intensity 635 nm diode laser irradiation inhibits fibroblast–myofibroblast transition reducing TRPC1 channel expression/activity: New perspectives for tissue fibrosis treatment

et al. 2015

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Low intensity irradiation with 635 ± 5 nm diode laser inhibited TGF-β1/Smad3-mediated fibroblast-myofibroblast transition and this effect involved the modulation of TRPC1 ion channels. These data contribute to support the potential anti-fibrotic effect of LLLT and may offer further informations for considering this therapy as a promising therapeutic tool for the treatment of tissue fibrosis.

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Section: Discussionmentioning

confidence: 99%

Low intensity 635 nm diode laser irradiation inhibits fibroblast–myofibroblast transition reducing TRPC1 channel expression/activity: New perspectives for tissue fibrosis treatment

et al. 2015

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“…Among these beneficial effects are skin rejuvenation [6], reduction of acne scars [7, 8], reduction of hypertrophic scars [9], and healing of burns [10, 11]. In addition, faster healing of an aseptic injured epithelium i.e.…”

Section: Introductionmentioning

confidence: 99%

Low‐level laser irradiation promotes the proliferation and maturation of keratinocytes during epithelial wound repair

Sperandio

Simões

Corrêa

et al. 2014

Journal of Biophotonics

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Low-level laser therapy (LLLT) has been extensively employed to improve epithelial wound healing, though the exact response of epithelium maturation and stratification after LLLT is unknown. Thus, this study aimed to assess the in vitro growth and differentiation of keratinocytes (KCs) and in vivo wound healing response when treated with LLLT. Human KCs (HaCaT cells) showed an enhanced proliferation with all the employed laser energy densities (3, 6 and 12 J/cm2, 660nm, 100mW), together with an increased expression of Cyclin D1. Moreover, the immunoexpression of proteins related to epithelial proliferation and maturation (p63, CK10, CK14) all indicated a faster maturation of the migrating KCs in the LLLT-treated wounds. In that way, an improved epithelial healing was promoted by LLLT with the employed parameters; this improvement was confirmed by changes in the expression of several proteins related to epithelial proliferation and maturation.

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“…This might in part be explained by the lack of guidelines for the optimal timing of preventive or therapeutic intervention and by the confirmation of positive results for hypertrophic scars by subjective assessments only in most studies. The level of evidence for laser therapy as a keloid treatment was found to be low . Further research is required to evaluate the single use or combination of different laser systems and to examine the outcome by use of objective parameters.…”

Section: Discussionmentioning

confidence: 98%

Internet‐based survey on current practice for evaluation, prevention, and treatment of scars, hypertrophic scars, and keloids

Lumenta

Siepmann

Kamolz

2014

Wound Repair Regeneration

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No universally accepted standard for evaluation, prevention, and treatment of scars, hypertrophic scars, and keloids exists. Following development of a questionnaire, we performed a closed Web-based survey among burn centers. Server-based data collection was performed over 4 weeks and closed thereafter. The poll revealed emerging new treatment schemes, but the majority of participants adhered to evaluation (Patient and Observer Scar Assessment Scale, Matching Assessment of Scars and Photographs, Vancouver Scar Scale, two-dimensional photography) and prevention (silicone gel sheets and compression garments) strategies that were in line with the currently available recommendations from the literature. We noted a low penetration for the use of objective evaluation tools in our poll and detected differences in surgical approaches to keloids. Based on the results of our survey and the power of currently available clinical recommendations, we expect future guidelines to gain more evidence-based power, especially when more high-quality clinical trials with objective evaluation support, clearly defined disease entities, and therapeutic outcome factors have become available.

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Laser Therapy for Prevention and Treatment of Pathologic Excessive Scars

Cited by 59 publications

References 36 publications

Low intensity 635 nm diode laser irradiation inhibits fibroblast–myofibroblast transition reducing TRPC1 channel expression/activity: New perspectives for tissue fibrosis treatment

Low intensity 635 nm diode laser irradiation inhibits fibroblast–myofibroblast transition reducing TRPC1 channel expression/activity: New perspectives for tissue fibrosis treatment

Low‐level laser irradiation promotes the proliferation and maturation of keratinocytes during epithelial wound repair

Internet‐based survey on current practice for evaluation, prevention, and treatment of scars, hypertrophic scars, and keloids

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