Laser Therapy for Onychomycosis: Fact or Fiction?

Liddell, Lucette Teel; Rosén, Ted

doi:10.3390/jof1010044

Cited by 13 publications

(7 citation statements)

References 36 publications

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“…Hence there is a need to treat the disease effectively. 12,13 Landsman et al have shown an efficacy of 19.2% with infrared light (IR) therapy in the treatment of Onychomycosis. 14 The IR spectrum may be arbitrarily divided by wavelength into near-IR (760-3000nm), middle-IR (3000-30000nm),&far-IR (30000nm-1 mm).…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Infrared Light Therapy in the Treatment of Onychomycosis

Sadal

Habib²

2023

PAFMJ

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Objective: To study the efficacy of Infrared light therapy in treating Onychomycosis. Study Design: Cross-sectional study. Place and Duration of Study: Department of Dermatology, Combined Military Hospital, Bahawalpur Pakistan, from Jan to Jul 2022. Methodology: A total of 122 patients of either gender with Onychomycosis were included in the study. Sessions with infrared light (24W Red Bulb, 660nm-850nm wavelength) were arranged once a week. The total duration of therapy consisted of four weeks in the case of fingernails and eight weeks in the case of toenails. Patients were called for follow-up at the end of the first, second, and third months after completion of treatment for efficacy evaluation. Results: The mean duration of complaints was 9.12±2.58 weeks, and the mean weight of patients was 84.11±8.38Kg. Male patients were 36(29.5%), and females were 86(70.5%). 98(80.3%) patients had toenail involvement, and 24(19.7%) patients had fingernail involvement. Efficacy was defined as 2/3rd (66.0%) clearance of the nail plate after 90 days of completion of treatment from the first observation at the time of presentation on visual examination. Efficacy in our study was observed in 25(20.5%) patients. Conclusion: Our study concluded that infrared light therapy is an effective treatment modality for Onychomycosis.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of Infrared Light Therapy in the Treatment of Onychomycosis

Sadal

Habib²

2023

PAFMJ

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“…Recent reviews on laser treatment of onychomycosis have concluded that the evidence for its effectiveness is limited and of poor methodological quality [ 22 , 50 , 51 ]. Current findings are largely based on studies with small sample sizes, differing definitions for outcome measures and a lack of control groups.…”

Section: Physical Treatmentsmentioning

confidence: 99%

Challenges and Opportunities in the Management of Onychomycosis

Christenson

Peterson

Naunton

et al. 2018

JoF

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Onychomycosis is an increasingly common fungal nail infection, chiefly caused by dermatophyte fungi. The disease is notoriously difficult to treat due to the deep-seated nature of fungi within the nail plate, prolonged treatment requirements, poor patient adherence and frequent recurrences. Given the poor efficacy of currently available topical and systemic therapies, there is a renewed interest in exploring alternative treatment modalities for onychomycosis. Natural therapies, physical treatments and various combination therapies have all shown potential for the management of onychomycosis, though research on many of these methods is still in preliminary stages. Further large, well-designed, randomised controlled trials are necessary to confirm the efficacy of these novel treatments in order to make formal recommendations regarding their use in the management of onychomycosis.

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“…Photodynamic therapy can be used in dermatology in the treatment of fungal infections and skin rejuvenation [19][20][21][22][23]. In this case, the modern chlorinecontaining photosensitizing drug Chloderm (Chloderm, Russia) is widely used [24].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Changes in Extinction Spectrum of Modern Chlorine-Containing Photosensitizing Drugs under the Visible Light Action

Беликов

Kozlova

Smirnov

et al. 2022

J-BPE

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The paper presents the results of a study of the extinction spectra (350-900 nm) of aqueous solutions of modern chlorine-containing photosensitizing drugs for photodynamic therapy "Chloderm" (Chloderm, Russia) and "Chloderm with hyaluronic acid" (Chloderm, Russia) before and after irradiation by visible light with wavelengths of 405 nm, 450 nm, and 656±10 nm, with exposure time 0-20 min and intensity 0-200 mW/cm 2 . It is demonstrated that the addition of hyaluronic acid does not deform the shape of the extinction spectrum of the photosensitizing drug but reduces its absorption in proportion to the drop in the concentration of the photosensitizer in the drug. Photodynamic light action in the investigated range of parameters leads to a slight decrease in the extinction coefficient of both drugs at the wavelengths of the exposure, but significantly reduces extinction and deforms the Qy 00 absorption band (600-700 nm), thereby changing the ratio of monomers and tetramers in the drugs. This band is most significantly deformed after exposure to light with a wavelength of 656±10 nm, the least -with a wavelength of 450 nm.

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Laser Therapy for Onychomycosis: Fact or Fiction?

Cited by 13 publications

References 36 publications

The Efficacy of Infrared Light Therapy in the Treatment of Onychomycosis

The Efficacy of Infrared Light Therapy in the Treatment of Onychomycosis

Challenges and Opportunities in the Management of Onychomycosis

Investigation of the Changes in Extinction Spectrum of Modern Chlorine-Containing Photosensitizing Drugs under the Visible Light Action

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