“…One such modality is laser therapy, which has been tested and approved as a cosmetic treatment for onychomycosis (64). Its fungicidal action occurs through a direct thermal effect and possibly via the generation of reactive oxygen species (65); however, there are no rigorous, randomized controlled trials testing it against current topical and oral therapies, making it difficult to evaluate its efficacy (64). Photodynamic therapy, ultrasound, and iontophoresis are also currently being explored as treatment modalities for onychomycosis but are only in the early stages of development (66).…”