Laser-structured bacterial nanocellulose hydrogels support ingrowth and differentiation of chondrocytes and show potential as cartilage implants

Ahrem, Hannes; Pretzel, David; Endres, Michaela; Conrad, Daniel C.; Courseau, Julien; Müller, Hartmut; Jaeger, Raimund; Kaps, Christian; Klemm, Dieter; Kinne, Raimund W.

doi:10.1016/j.actbio.2013.12.004

Cited by 94 publications

(42 citation statements)

References 32 publications

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“…Laser perforation causes no chemical modifications and no reduction in mechanical strength. Laser perforated BC supported the ingrowth and re-differentiation of human articular chondrocytes, which migrated through the channels into the inner matrix (Ahrem et al, 2014). Jing et al (2011) described the attachment and proliferation of chondrogenic rat cells onto a patterned BC surface.…”

Section: Fig 4 Scanning Electron Micrograph Of Freeze-dried Bacterimentioning

confidence: 99%

Bacterial cellulose as a material for wound treatment: Properties and modifications. A review

Sulaeva

Henniges

Rosenau

et al. 2015

Biotechnology Advances

364

275

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Section: Fig 4 Scanning Electron Micrograph Of Freeze-dried Bacterimentioning

confidence: 99%

Bacterial cellulose as a material for wound treatment: Properties and modifications. A review

Sulaeva

Henniges

Rosenau

et al. 2015

Biotechnology Advances

364

275

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“…However, its dense nanocellulose network prevents cells from penetrating the material. To circumvent this problem, several techniques have been developed to support cell ingrowth in BNC scaffolds by tuning pore size and pore interconnectivity during biosynthesis of BNC [35], via laser ablation [10] and freeze-dry processing [36,37]. Such macroporous BNC scaffolds have been shown to provide an adequate environment that supports ingrowth and differentiation of chondrocytes.…”

Section: Introductionmentioning

confidence: 99%

“…For such cases, the field of tissue engineering (TE) provides a promising potential alternative therapy to the conventional and complex surgical reconstruction of auricular cartilage by using ear-shaped autologous costal and nasoseptal cartilage [1][2][3]. Bacterial nanocellulose (BNC), a novel biomaterial with excellent biocompatibility and remarkable tissue integration capability [4][5][6][7][8], has been evaluated for several TE strategies and has shown to support adhesion, proliferation and differentiation of different cell types [9][10][11][12][13][14][15]. BNC is a natural biopolymer synthesized by various bacteria species, particularly Gluconacetobacter xylinus [16,17].…”

Section: Introductionmentioning

confidence: 99%

Novel bilayer bacterial nanocellulose scaffold supports neocartilage formation in vitro and in vivo

et al. 2015

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“…5). The mechanical properties of the hydrogels were not significantly different from those of nonperforated hydrogels [33].…”

Section: Enzymatic Production Of Nanocellulosementioning

confidence: 96%

Section: Enzymatic Production Of Nanocellulosementioning

confidence: 99%

Nanocellulose and Proteins: Exploiting Their Interactions for Production, Immobilization, and Synthesis of Biocompatible Materials

Fritz

Jeuck

Salas

et al. 2015

Advances in Polymer Science

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Nanocellulose has been used with promising results as reinforcement material in composites, many of which include hydrophobic polymers. However, the hydrophilic nature of nanocellulose can be better exploited in composites that incorporate high surface energy systems as well as in applications that can benefit from such properties. In fact, proteins can be ideal components in these cases. This paper reviews such aspects, which are based on the remarkable mechanical properties of nanocellulose. This material also exhibits low density, high aspect ratio, high surface area, and can be modified by substitution of its abundant hydroxyl groups. It also shows biocompatibility, low toxicity, and biodegradability. Convenient biotechnological methods for its production are of interest not only because of the possible reduction in processing energy but also because of positive environmental aspects. Thus, enzymatic treatments are favorable for effecting fiber deconstruction into nanocellulose. In addition to reviewing nanocellulose production by enzymatic routes, we discuss incorporation of enzyme activity to produce biodegradable systems for biomedical applications and food packaging. Related applications have distinctive features that take advantage of protein-cellulose interactions and the possibility of changing nanocellulose properties via enzymatic or protein treatments.

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Laser-structured bacterial nanocellulose hydrogels support ingrowth and differentiation of chondrocytes and show potential as cartilage implants

Cited by 94 publications

References 32 publications

Bacterial cellulose as a material for wound treatment: Properties and modifications. A review

Bacterial cellulose as a material for wound treatment: Properties and modifications. A review

Novel bilayer bacterial nanocellulose scaffold supports neocartilage formation in vitro and in vivo

Nanocellulose and Proteins: Exploiting Their Interactions for Production, Immobilization, and Synthesis of Biocompatible Materials

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