Laser Speckle Contrast Imaging in Neurosurgery: A Systematic Review

Konovalov, A N; Gadzhiagaev, Vadim; Grebenev, Fyodor; Stavtsev, D. D.; Piavchenko, Gennadii.A.; Gerasimenko, Alexander Yu.; Telyshev, D. V.; Meglinski, Igor; Eliava, Shalva

doi:10.1016/j.wneu.2022.12.048

Cited by 22 publications

(18 citation statements)

References 15 publications

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“…Notably, the cost-effectiveness of essential instrumentation, the ease of implementation, and the affordability of optical components utilized in measurements underscore the invaluable resource that the DLS-based approach has become for clinical applications. [238] Furthermore, the integration of DLS with other imaging and electrophysiological modalities holds great promise for multiparameter recording of intricate biological phenomena. This multi-modal approach stands poised to provide a deeper understanding of complex physiological processes.…”

Section: Discussionmentioning

confidence: 99%

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Advances in Dynamic Light Scattering Imaging of Blood Flow

Sdobnov,

Piavchenko,

Bykov

et al. 2023

Laser & Photonics Reviews

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Dynamic light scattering (DLS) is a well known experimental approach uniquely suited for the characterization of small particles undergoing Brownian motion in randomly inhomogeneous turbid scattering medium, including water suspension, polymers in solutions, cells cultures, and so on. DLS is based on the illuminating of turbid medium with a coherent laser light and further analyzes the intensity fluctuations caused by the motion of the scattering particles. The DLS‐based spin‐off derivative techniques, such laser Doppler flowmetry (LDF), diffusing wave spectroscopy (DWS), laser speckle contrast imaging (LSCI), and Doppler optical coherence tomography (DOCT), are exploited widely for non‐invasive imaging of blood flow in brain, skin, muscles, and other biological tissues. The recent advancements in the DLS‐based imaging technologies in frame of their application for brain blood flow monitoring, skin perfusion measurements, and non‐invasive blood micro‐circulation characterization are overviewed. The fundamentals, breakthrough potential, and practical findings revealed by DLS‐based blood flow imaging studies, including the limitations and challenges of the approach such as movement artifacts, non‐ergodicity, and overcoming high scattering properties of studied medium, are also discussed. It is concluded that continued research and further technological advancements in DLS‐based imaging will pave the way for new exciting developments and insights into blood flow diagnostic imaging.

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Section: Discussionmentioning

confidence: 99%

“…Notably, the cost‐effectiveness of essential instrumentation, the ease of implementation, and the affordability of optical components utilized in measurements underscore the invaluable resource that the DLS‐based approach has become for clinical applications. [ 238 ]…”

Section: Discussionmentioning

confidence: 99%

Advances in Dynamic Light Scattering Imaging of Blood Flow

Sdobnov,

Piavchenko,

Bykov

et al. 2023

Laser & Photonics Reviews

Self Cite

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“…Each series of images was then processed using a custom-developed temporal speckle contrast algorithm [5] based on MAT-LABr2019b software, assisted by a standard Fiji/ImageJ plugin [41]. This approach has been successfully used in transcranial vascular imaging [24] and cross-validated using fluorescent intravital microscopy [37], among other studies [42].…”

Section: Methodsmentioning

confidence: 99%

Beyond Life: Exploring Hemodynamic Patterns in Postmortem Mice Brains

Sdobnov,

Bykov,

Piavchenko

et al. 2024

Preprint

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We use Laser Speckle Contrast Imaging (LSCI) for transcranial visualization of cerebral blood flow microcirculation in mice during and after cardiac arrest. Analyzing time series of LSCI images, we observed temporal variations in blood flow distribution across the brain surface for up to several hours postmortem. Utilizing Fast Fourier Transform (FFT) analysis, we depicted the decay in blood flow oscillations and microcirculation following death. Due to the exponential drop in blood flow intensity and ensuing non-stationary conditions, Continuous Wavelet Transform (CWT) was applied to identify potential spatial or temporal synchronization patterns in cerebral hemodynamics. Additionally, we conducted Non-negative Matrix Factorization (NMF) analysis with four components to segment LSCI images, revealing temporal alterations in structural subcomponents. This integrated approach, combining LSCI, FFT, CWT and NMF, provides a comprehensive tool for understanding cerebral blood flow dynamics in mice, metaphorically capturing the end of the tunnel experience. Results indicated a primary localization of hemodynamic activity in the olfactory bulbs postmortem, followed by minor successive relocations of blood microflows between the somatosensory and visual cortical regions via the superior sagittal sinus. The proposed approach opens avenues for further exploration into these phenomena, potentially bridging the gap between neuroscientific understanding and the longstanding mysteries surrounding consciousness and perception at the end of life.

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“…The variant in which our work was performed implies the use of the exoscope principle. We have not seen in the literature LVSC systems integrated into a neurosurgical exoscope 1 .…”

Section: Lsci In Modern Neurosurgery and Its Limitationsmentioning

confidence: 98%

Real-time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment. Animal experimental study.

Konovalov,

Grebenev,

Stavtsev

et al. 2023

Preprint

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The use of various blood flow control methods in neurovascular interventions is crucial for reducing postoperative complications. Neurosurgeons worldwide use different methods, such as contact Dopplerography, intraoperative indocianine videoangiography (ICG) video angiography, fluorescein angiography, flowmetry, intraoperative angiography, direct angiography, etc. However, there is no noninvasive method that can assess the presence of blood flow in the vessels of the brain without the introduction of fluorescent substances throughout the intervention. The real-time laser-speckle contrast imaging (LSCI) method was studied for its effectiveness in controlling blood flow in standard cerebrovascular surgery cases in rat common carotid arteries, such as proximal occlusion, trapping, reperfusion, anastomosis, and intraoperative vessel thrombosis. The real-time LSCI method is a promising method for use in neurosurgical practice. It allows timely diagnosis of intraoperative disturbance of blood flow in the vessels in case of clip occlusion or thrombosis. Additionally, LSCI allows us to reliably confirm the functioning of the anastomosis and reperfusion after removal of the clips and thrombolysis in real time. An unresolved limitation of the method is noise from movements, but this does not reduce the value of the method. Additional research is required to improve the quality of the data obtained.

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Laser Speckle Contrast Imaging in Neurosurgery: A Systematic Review

Cited by 22 publications

References 15 publications

Advances in Dynamic Light Scattering Imaging of Blood Flow

Advances in Dynamic Light Scattering Imaging of Blood Flow

Beyond Life: Exploring Hemodynamic Patterns in Postmortem Mice Brains

Real-time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment. Animal experimental study.

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