Laser printing based colorimetric paper sensors for glucose and ketone detection: Design, fabrication, and theoretical analysis

Mukhopadhyay, Mainak; Subramanian, Sri Ganesh; Durga, K. Vijaya; Sarkar, Debasish; DasGupta, Sunando

doi:10.1016/j.snb.2022.132599

Cited by 7 publications

(2 citation statements)

References 34 publications

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“…Over the last decade, it has been utilised extensively to develop point-of-care diagnostic devices for cost effective, accurate, and user-friendly testing in resource constrained settings [3]. Their material and fabrication cost have also been minimized by implementing printing techniques for large-scale production, e.g., laser [4] and wax printing [5]. However, certain limitations of paper devices (µPADs) such as fixed pore dimensions and imprecise flow control, could have an impact on the accuracy and reproducibility of certain assays, restricting their utility for on-field testing [6], [7].…”

Section: Introductionmentioning

confidence: 99%

Rapid Hematocrit Estimation Using a Fold-Crease Induced Fast Flowing Paper Sensor

Dash,

Mukhopadhyay,

Shaw

et al. 2024

Preprint

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Increased evaporative losses and flow obstructions can present substantial impediments to current paper analytical devices (μPADs) for efficient on-site testing of biological fluids. Strategic enhancements in wicking rates of paper may thereby counter these limitations and enable on-demand healthcare monitoring. Therefore, herein we have leveraged the features of paper fold-crease regions, for the very first time, and developed a novel fast-flowing platform using laser printing to accelerate fluid flow through paper. A series of extensive experiments have been conducted to optimize the design and maximize wicking rates of μPADs for smaller liquid volumes, making it well-suited for analysing biofluids. The investigation delves into structural alterations within the creased regions, employing both static and dynamic force application strategies. A first-generation Washburn type model in excellent agreement with the experimental findings is developed, providing a comprehensive insight into the fundamental physics involved. Finally, the folded channels are utilized for a distance-based hematocrit sensor employing grade-1 filter paper at very low-cost, simplified fabrication, lesser sample volume and faster analysis. The findings of this work unveil a plethora of potentialities for employing paper and paper folds to develop affordable medical devices with advanced analytical functionalities, specifically tailored for the resource-constrained settings.

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Section: Introductionmentioning

confidence: 99%

Rapid Hematocrit Estimation Using a Fold-Crease Induced Fast Flowing Paper Sensor

Dash,

Mukhopadhyay,

Shaw

et al. 2024

Preprint

Self Cite

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“…for detection of diseases [11], it was understood that the final dried patterns of complex biofluids are more complex than that of pure solutions as even minor changes in the initial composition of the contents of the body fluids led to signatory differences in the final morphologies of the dried droplets. Thus, investigating the sole effect of various components on the evaporation dynamics and the resulting drying patterns became essential for fundamental explorations and understanding, to further aid in disease detection [12][13][14]. Studies related to the drying of model systems/solutions became pre-eminent where these bio-fluids were modelled as a suspension of colloidal particles based on their size, shape, and concentrations.…”

Section: Introductionmentioning

confidence: 99%

Desiccation Patterns of Particle Laden Salt Droplets

Mukhopadhyay

Subramanian

Nair

et al. 2023

Preprint

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Drying of complex fluids leads to the formation of several intricate patterns where each component plays a unique role in determining the final dried morphologies. Salts are essential to body fluids (viz. blood, urine, saliva) and buffer solutions. Hence, understanding the sole effect of salts on the dried patterns of complex fluids has become imperative. In the present investigation, the exclusive effects of some commonly available salts on the final dried patterns of model solutions in the presence of polystyrene particles have been explored. Fascinating results have been observed as the sole presence of salts was found to alter the final dried patterns of the particle suspensions. To delve deeper into the physics of evaporation dynamics, a qualitative analysis has also been undertaken to estimate the predominant forces affecting the dried droplet morphologies. This investigation can serve as a baseline for understanding the underlying mechanisms involved during the drying of complex fluids to further aid in disease diagnosis.

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Selective colorimetric sensors and diagnostic microfiber yarn for carbonyl groups via ion-pairing dyes with plural chromatic behaviors

Kim,

Lee,

Ahn

et al. 2024

Chemical Engineering Journal

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Laser printing based colorimetric paper sensors for glucose and ketone detection: Design, fabrication, and theoretical analysis

Cited by 7 publications

References 34 publications

Rapid Hematocrit Estimation Using a Fold-Crease Induced Fast Flowing Paper Sensor

Rapid Hematocrit Estimation Using a Fold-Crease Induced Fast Flowing Paper Sensor

Desiccation Patterns of Particle Laden Salt Droplets

Selective colorimetric sensors and diagnostic microfiber yarn for carbonyl groups via ion-pairing dyes with plural chromatic behaviors

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