Laser‐polarized 3He as a probe for dynamic regional measurements of lung perfusion and ventilation using magnetic resonance imaging

Viallon, Magalie; Berthezène, Yves; Décorps, M.; Wiart, Marlène; Callot, Virginie; Bourgeois, Marc; Humblot, H.; Briguet, A.; Crémillieux, Yannick

doi:10.1002/1522-2594(200007)44:1<1::aid-mrm1>3.3.co;2-l

Cited by 24 publications

(29 citation statements)

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“…Cremillieux et al (10) combine the use of hyperpolarized 3 He gas for ventilation and contrast-enhanced perfusion imaging using gadolinium diethylene triamine pentaacetic acid (Gd-DTPA). Viallon et al (11) investigate the use of superparamagnetic iron oxide nanoparticles to induce an increase in magnetic susceptibility in the lung, which modulates 3 He signal, thereby allowing for the acquisition of simultaneous ventilation and perfusion images. Chen et al (17) propose the use of oxygen as a paramagnetic agent for ventilation imaging and Gd-DTPA contrast enhanced study for perfusion imaging.…”

Section: Discussionmentioning

confidence: 99%

MR ventilation‐perfusion imaging of human lung using oxygen‐enhanced and arterial spin labeling techniques

Bankier

Prasad

et al. 2001

Magnetic Resonance Imaging

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Magnetic resonance ventilation-perfusion (V/Q) imaging has been demonstrated using oxygen and arterial spin labeling techniques. Inhaled oxygen is used as a paramagnetic contrast agent in ventilation imaging using a multiple inversion recovery (MIR) approach. Pulmonary perfusion imaging is conducted using a flow-sensitive alternating inversion recovery with an extra radiofrequency pulse (FAIRER) technique. A half Fourier single-short turbo spin echo (HASTE) sequence is used for data acquisition in both techniques. V/Q imaging was performed in ten of the twenty volunteers, while either ventilation or perfusion was imaged in the other ten. This V/Q imaging scheme is completely noninvasive, does not involve ionized radiation, and shows promising potential for clinical use in the diagnosis of lung diseases such as pulmonary embolism. J. Magn. Reson. Imaging 2001;14: 574 -579.

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Section: Discussionmentioning

confidence: 99%

MR ventilation‐perfusion imaging of human lung using oxygen‐enhanced and arterial spin labeling techniques

Bankier

Prasad

et al. 2001

Magnetic Resonance Imaging

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“…Some efforts have been made (27) to evaluate such perfusion/ventilation defects in a porcine model using contrast-enhanced perfusion imaging and oxygen-enhanced ventilation imaging approaches. Another method using 3 He itself for dynamic measurement of lung perfusion as well as ventilation has also been reported (28). To date, however, MR techniques using proton and 3 He imaging to visualize lung structure have only been reported for assessing perfusion and ventilation in rat lungs (29).…”

mentioning

confidence: 99%

Combined MR proton lung perfusion/angiography and helium ventilation: Potential for detecting pulmonary emboli and ventilation defects

Zheng

Leawoods

Nolte

et al. 2002

Magnetic Resonance in Med

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Three-dimensional (3D) perfusion imaging allows the assessment of pulmonary blood flow in parenchyma and main pulmonary arteries simultaneously. MRI using laser-polarized 3 He gas clearly shows the ventilation distribution with high signal-tonoise ratio (SNR). In this report, the feasibility of combined lung MR angiography, perfusion, and ventilation imaging is demonstrated in a porcine model. Ultrafast gradient-echo sequences have been used for 3D perfusion and angiographic imaging, in conjunction with the use of contrast agent injections. 2D multiple-section 3 He imaging was performed subsequently by inhalation of 450 ml of hyperpolarized 3 He gas. The MR techniques were examined in a series of porcine models with externally delivered pulmonary emboli and/or airway occlusions. The development of high-speed gradient systems and fast imaging methods has permitted ultrafast contrast-enhanced lung perfusion imaging with subsecond temporal resolution and millimeter spatial resolution (1-8). Imaging of the lung parenchyma suffers from low proton density, physiological motion (cardiac and respiratory motion adjacent to the lung), and short T* 2 from local magnetic field inhomogeneity due to multiple interfaces of air and soft tissues (3,9 -12); significantly reduced times TR and TE in the gradient-echo sequence allow dramatically improved SNR. Recently, bolus injection of gadolinium contrast agent in conjunction with an ultrafast 3D gradient-echo sequence has demonstrated volumetric lung parenchymal perfusion images with 2-3 sec temporal resolution (7). This technique allows simultaneous evaluation of lung perfusion and flow in the major pulmonary vasculature. On the other hand, submillimeter high-spatial-resolution pulmonary angiography has been achieved with bolus administration of gadolinium contrast agent and first-pass MR data acquisition during the arterial phase of the contrast agent (13-15). This contrast-enhanced pulmonary angiography shows high SNR and can depict pulmonary arteries beyond the subsegmental branches. Integration of perfusion and angiography may allow better evaluation of parenchymal blood flow states and vasculature involvement; this is particularly interesting when pulmonary emboli are studied (10,16).The ability of MR to image the lung air space is important for the diagnosis of a variety of pulmonary ventilation abnormalities. Recently, assessment of regional lung ventilation using hyperpolarized noble gas has emerged as an imaging technique for evaluating patients with lung disease, such as tumor, emphysema, bronchiectasis, cystic fibrosis, and asthma (17-24). Compared to O 2 -enhanced lung MRI (25,26), which has the advantage of needing no special equipment, 3 He MRI provides high SNR and contrast-to-noise ratio (CNR), with image intensity directly proportional to the local concentration of inhaled 3 He. It has long been recognized that both pulmonary perfusion and ventilation images are needed to identify and distinguish certain lung diseases. For example, mismatched and matched perfusi...

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“…Since these studies rely on reporting changes in the T2 (or phase) of the protons of the surrounding tissues, their application is severely restricted in the lungs, where the proton concentration is low. Finally, there are two published reports (27,28) that have investigated the possibility for using HP gas and injection of superparamagnetic iron oxide nanoparticles to measure lung perfusion. One of the significant differences between their studies and our report is that they rely on magnitude images to gain insight into perfusion.…”

Section: Discussionmentioning

confidence: 99%

Indirect detection of lung perfusion using susceptibility‐based hyperpolarized gas imaging

Dimitrov

Insko

Rizi

et al. 2005

Magnetic Resonance Imaging

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Purpose:To address the problem of inadequate signal-tonoise ratio (SNR) encountered in lung perfusion magnetic resonance imaging (MRI) by developing an indirect detection based on the strong hyperpolarized (HP) gas signal. Materials and Methods:Our model is based on detecting the effects of gadolinium (Gd) flowing through lung capillaries by recording the phase of the nearby alveolar HP gas. In a HP gas 3 He phantom we imaged gas phases before and after removing tubes containing paramagnetic solution away from the phantom. We also imaged HP gas phases in pig lungs before and after injection of Gd. Finally, parenchymal spin phase in excised lungs was measured as a function of Gd concentration. Results:In the phantom, the differential phase map displayed a pattern characteristic of a susceptibility-induced dipole field, showing the possibility of an indirect detection. In vivo, the differential phase map showed homogeneous appearance, as expected for uniform perfusion in healthy lungs. Ex vivo, the parenchymal spin phases were shown to depend linearly on Gd concentration. Conclusion:Our method should allow indirect perfusion (Q) and direct ventilation (V) to be assessed simultaneously, thus allowing for diagnosis of V/Q mismatches. The linear dependency of parenchymal spin phase vs. Gd concentration may allow for quantification of lung perfusion.

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Laser‐polarized 3He as a probe for dynamic regional measurements of lung perfusion and ventilation using magnetic resonance imaging

Cited by 24 publications

References 0 publications

MR ventilation‐perfusion imaging of human lung using oxygen‐enhanced and arterial spin labeling techniques

MR ventilation‐perfusion imaging of human lung using oxygen‐enhanced and arterial spin labeling techniques

Combined MR proton lung perfusion/angiography and helium ventilation: Potential for detecting pulmonary emboli and ventilation defects

Indirect detection of lung perfusion using susceptibility‐based hyperpolarized gas imaging

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