Laser polarization noise elimination in sensitive polarimetric systems

Baba, Justin S.; Chung, Jungrae; Coté, Gerard L.

doi:10.1117/1.1464869

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Furthermore, we demonstrate that this method can be applied to reduce the disturbance impact of scattering by turbid media on glucose predictability. This is an alternative method to other approaches using closed loop systems [3,[13][14][15][16] and PEM-modulated polarimeters [7,9,11,17,18] as described in subsection 2.2.…”

mentioning

confidence: 99%

Real-time compensation method for robust polarimetric determination of glucose in turbid media

Stark

Behroozian

Redmer

et al. 2018

Biomed. Opt. Express

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Polarimetric determination of glucose is known to be strongly affected by scattering in turbid media. Other effects like fluctuations of light source emission and sample absorption also deteriorate glucose predictability. This work presents a measurement setup using a real-time data processing method to address these problems. The approach uses the frequency-dependent intensity components created when the polarization of the incident light is periodically modulated by a Faraday rotator. The efficacy of the proposed method was verified experimentally for a glucose range of 0 − 500 mg/dl. It was shown that the approach reduces the prediction errors in slightly turbid media from 35.7 mg/dl down to 1.17 mg/dl. In a similar way, the glucose predictability for fluctuating light source emission was improved from ±16.16 mg/dl to ±1 mg/dl and for varying sample absorbance from ±15.69 mg/dl to ±1.23 mg/dl, respectively. Therefore, considerable improvement of robustness and reproducibility of glucose determination was demonstrated.

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mentioning

confidence: 99%

Real-time compensation method for robust polarimetric determination of glucose in turbid media

Stark

Behroozian

Redmer

et al. 2018

Biomed. Opt. Express

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“…It has been shown that this combination of a quarterwave plate and a linear polarizer reduces the noise due to inherent fluctuations in laser polarization. 29 Both the beams then pass through respective in-house-built Faraday rotators that act as rotation compensators and are present only for closed-loop operation. These compensators consist of 1-cm-long terbium-gallium-garnet ͑TGG͒ crystals ͑Deltronic Crystals, Inc., Dover, New Jersey͒ inside electrical coils.…”

Section: Dual-wavelength Optical Polarimetermentioning

confidence: 99%

Real-time, closed-loop dual-wavelength optical polarimetry for glucose monitoring

Malik

Coté

2010

J. Biomed. Opt.

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Abstract. The development of a real-time, dual-wavelength optical polarimetric system to ultimately probe the aqueous humor glucose concentrations as a means of noninvasive diabetic glucose monitoring is the long-term goal of this research. The key impact of the work is the development of an approach for the reduction of the time-variant corneal birefringence due to motion artifact, which is still a limiting factor preventing the realization of such a device. Our dualwavelength approach utilizes real-time, closed-loop feedback that employs a classical three-term feedback controller and efficiently reduces the effect of motion artifact that appears as a common noise source for both wavelengths. In vitro results are shown for the openloop system, and although the dual-wavelength system helps to reduce the noise, it is shown that closed-loop control is necessary to bring the noise down to a sufficient level for physiological monitoring. Specifically, in vitro measurement results with the closed-loop dualwavelength approach demonstrate a sensitivity of 12.8 mg/ dl across the physiologic glucose range in the presence of time-variant test cell birefringence. Overall, it is shown that this polarimetric system has the potential to be used as a noninvasive measure of glucose for diabetes.

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Size and Shape Prediction of Colloidal Metal Oxide MgBaFeO Particles from Light Scattering Measurements

et al. 2006

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Laser polarization noise elimination in sensitive polarimetric systems

Cited by 4 publications

References 18 publications

Real-time compensation method for robust polarimetric determination of glucose in turbid media

Real-time compensation method for robust polarimetric determination of glucose in turbid media

Real-time, closed-loop dual-wavelength optical polarimetry for glucose monitoring

Size and Shape Prediction of Colloidal Metal Oxide MgBaFeO Particles from Light Scattering Measurements

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