Laser-photosensitizer assisted immunotherapy: a novel modality for cancer treatment

Chen, Wei R.; Adams, Robert L.; Carubelli, R.; Nordquist, Robert E.

doi:10.1016/s0304-3835(97)04707-1

Cited by 245 publications

(165 citation statements)

References 17 publications

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“…A vaccination effect has been suggested to be important for the effect of the two chemotherapy models cytosine deaminase/5-fluorocytosine (Consalvo et al, 1995;Kuriyama et al, 1999b;Morris, 1999;Pierrefite-Carle et al, 1999) and herpes simplex virus thymidine kinase/ganciclovir (Barba et al, 1994;Yamamoto et al, 1997;Kuriyama et al, 1999a), and for the effect of photodynamic therapy (PDT) (Chen et al, 1997;Chen et al, 1999). These modalities induce tumour cell necrosis, and an inflammatory microenvironment, which is critical for eliciting an efficient immune response (Melcher et al, 1998;Todryk et al, 1999;Sauter et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Resistance to tumour challenge after tumour laser thermotherapy is associated with a cellular immune response

et al. 2005

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Previous studies in our laboratory have shown that interstitial laser thermotherapy (ILT) of an experimental liver tumour is superior to surgical excision, at least partly due to a laser-induced immunological effect. The aim of the present study was to investigate the time -response relationship of the ILT-induced immunisation and the cellular response of macrophages and lymphocytes. A dimethylhydrazine-induced adenocarcinoma was transplanted into the liver of syngeneic rats. Rats with tumour were treated 6 -8 days later (tumour size 0.25 -0.40 cm 3 ) with ILT of tumour or resection of the tumour-bearing lobe. Two groups of rats without tumour were treated with resection of a normal liver lobe or ILT of normal liver. A challenging tumour was implanted into the liver of each rat 2, 5 or 10 weeks after primary treatment. Rats were killed 6, 12 and 48 days (or earlier due to their condition) after challenge (n ¼ 8 in all groups). Immunohistochemical techniques were used to determine lymphocytes (CD8, CD4) and macrophages (ED1, ED2) in rats having had treatment of a primary tumour. Interstitial laser thermotherapy of the first tumour was followed by eradication of challenging tumour and absence of tumour spread. This contrasted with rapid growth and spread of challenging tumour in the other groups. In the challenging vital tumour tissue and in the interface between the tumour and surroundings, the number of ED1 macrophages and CD8 lymphocytes was higher in rats having been treated with the ILT of tumour than in those having undergone resection of the tumour-bearing lobe. The number of ED2 macrophages and CD4 lymphocytes was low and did not vary between these two groups. Interstitial laser thermotherapy elicited an immune response that eradicated a challenging tumour and was associated with increased numbers of tumour-infiltrating macrophages and CD8 lymphocytes.

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Section: Discussionmentioning

confidence: 99%

Resistance to tumour challenge after tumour laser thermotherapy is associated with a cellular immune response

et al. 2005

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“…Selectivity is achieved by focused directional control or invasive [40][41][42] (fiber optic) positioning of the incident radiation, often pulsed [28][29][30] or continuous wave [24-28, 30, 48] (cw) laser, and is typically accompanied by preferential administration of photoactive molecules [60][61][62] or nano-scale particles. Photoexcitation of the latter two results in nonradiative relaxation by local heat transfer to the surrounding tumor environment.…”

Section: Introductionmentioning

confidence: 99%

Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice

et al. 2008

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Plasmonic photothermal therapy (PPTT) is a minimally-invasive oncological treatment strategy in which photon energy is selectively administered and converted into heat sufficient to induce cellular hyperthermia. The present work demonstrates the feasibility of in vivo PPTT treatment of deep-tissue malignancies using easily-prepared plasmonic gold nanorods and a small, portable, inexpensive near-infrared (NIR) laser. Dramatic size decreases in squamous cell carcinoma xenografts were observed for direct (P<0.0001) and intravenous (P<0.0008) administration of pegylated gold nanorods in nu/nu mice. Inhibition of average tumor growth for both delivery methods was observed over a 13-day period, with resorption of >57% of the directly-injected tumors and 25% of the intravenously-treated tumors.

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“…Recently, a novel therapy using laser-assisted photothermal interaction and adjuvant-enhanced immunostimulation has been developed [35]. Its preclinical and preliminary clinical results showed promising outcomes [36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Improvement of DC vaccine with ALA-PDT induced immunogenic apoptotic cells for skin squamous cell carcinoma

Wang

2015

Photodiagnosis and Photodynamic Therapy

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Laser-photosensitizer assisted immunotherapy: a novel modality for cancer treatment

Cited by 245 publications

References 17 publications

Resistance to tumour challenge after tumour laser thermotherapy is associated with a cellular immune response

Resistance to tumour challenge after tumour laser thermotherapy is associated with a cellular immune response

Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice

Improvement of DC vaccine with ALA-PDT induced immunogenic apoptotic cells for skin squamous cell carcinoma

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