Laser-Mediated Photodynamic Therapy of Actinic Keratoses

Alexiades-Armenakas, Macrene; Geronemus, Roy G.

doi:10.1001/archderm.139.10.1313

Cited by 159 publications

(128 citation statements)

References 18 publications

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, PDL/PDT has been reported to be successful in the clinical eradication of actinic keratoses and in the treatment of actinic cheilitis. 43,44 Thus, it was somewhat surprising that a similar treatment did not alter p53 immunostaining in our study. It is possible that more rapid uptake of the 5-ALA by the more quickly proliferating cells within the actinic keratoses treated in the prior study 44 resulted in more efficient alteration of these clinically apparent lesions compared with the simply sun-damaged (but nonlesional) skin of our patients.…”

Section: Commentmentioning

confidence: 49%

Molecular Effects of Photodynamic Therapy for Photoaging

et al. 2008

View full text Add to dashboard Cite

show abstract

Section: Commentmentioning

confidence: 49%

Molecular Effects of Photodynamic Therapy for Photoaging

et al. 2008

View full text Add to dashboard Cite

show abstract

“…These results were extended by Alexiades-Armenakas and Geronemus, 6 who showed that photodynamic treatment of actinic keratoses could be accomplished not only with IPL but also with a 595-nm pulsed-dye laser (PDL) (Vbeam; Candela Corporation, Wayland, Mass). The PDL offered the benefits of rapidity of treatment and the comfort and protective epidermal effects associated with cryogen spray cooling.…”

Section: Commentmentioning

confidence: 94%

Topical 5-Aminolevulinic Acid Combined With Intense Pulsed Light in the Treatment of Photoaging

Dover¹,

Bhatia²,

Stewart³

et al. 2005

Arch Dermatol

197

142

View full text Add to dashboard Cite

Background:The adjunctive use of 5-aminolevulinic acid (5-ALA) with intense pulsed-light (IPL) treatments has been suggested to increase the benefit of IPL for photoaging; however, to our knowledge, no controlled trials have been performed.Design: A prospective, randomized, controlled, splitface study was designed. Twenty subjects participated in a series of 3 split-face treatments 3 weeks apart in which half of the face was pretreated with 5-ALA followed by IPL treatment while the other half was treated with IPL alone. Two additional full-face treatments (with IPL alone) were then delivered 3 weeks apart. Assessment of global photodamage, fine lines, mottled pigmentation, tactile roughness, and sallowness (on a scale of 0-4) was performed by a blinded investigator before each treatment and 4 weeks after the final treatment. Patients also completed an assessment at the conclusion of the study comparing their results with pretreatment photographs.Results: All 20 volunteers completed the study. Pretreatment with 5-ALA resulted in more improvement in the global score for photoaging (16 [80%] subjects vs 9 [45%] subjects; P = .008) and mottled pigmentation (19 [95%] subjects vs 12 [60%] subjects; P= .008) than IPL

show abstract

“…It is possible that other PDT treatment conditions would be less painful while maintaining efficacy, and we are investigating this possibility. Short-contact ALA and/or pulsed light sources [42][43][44] have been used for extended areas on the face without significant discomfort, but these conditions deliver a small PDT dose, and these approaches have not been substantially effective for BCC. Photodynamic therapy with ALA methylester has been used for individual BCCs and may cause less discomfort, although pain has been reported 45,46 ; the surface preparation used in these studies would be impractical for our patients.…”

Section: Treatment Parametersmentioning

confidence: 99%