2003
DOI: 10.1001/archderm.139.10.1313
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Laser-Mediated Photodynamic Therapy of Actinic Keratoses

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Cited by 159 publications
(128 citation statements)
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“…Furthermore, PDL/PDT has been reported to be successful in the clinical eradication of actinic keratoses and in the treatment of actinic cheilitis. 43,44 Thus, it was somewhat surprising that a similar treatment did not alter p53 immunostaining in our study. It is possible that more rapid uptake of the 5-ALA by the more quickly proliferating cells within the actinic keratoses treated in the prior study 44 resulted in more efficient alteration of these clinically apparent lesions compared with the simply sun-damaged (but nonlesional) skin of our patients.…”
Section: Commentmentioning
confidence: 49%
“…Furthermore, PDL/PDT has been reported to be successful in the clinical eradication of actinic keratoses and in the treatment of actinic cheilitis. 43,44 Thus, it was somewhat surprising that a similar treatment did not alter p53 immunostaining in our study. It is possible that more rapid uptake of the 5-ALA by the more quickly proliferating cells within the actinic keratoses treated in the prior study 44 resulted in more efficient alteration of these clinically apparent lesions compared with the simply sun-damaged (but nonlesional) skin of our patients.…”
Section: Commentmentioning
confidence: 49%
“…These results were extended by Alexiades-Armenakas and Geronemus, 6 who showed that photodynamic treatment of actinic keratoses could be accomplished not only with IPL but also with a 595-nm pulsed-dye laser (PDL) (Vbeam; Candela Corporation, Wayland, Mass). The PDL offered the benefits of rapidity of treatment and the comfort and protective epidermal effects associated with cryogen spray cooling.…”
Section: Commentmentioning
confidence: 94%
“…It is possible that other PDT treatment conditions would be less painful while maintaining efficacy, and we are investigating this possibility. Short-contact ALA and/or pulsed light sources [42][43][44] have been used for extended areas on the face without significant discomfort, but these conditions deliver a small PDT dose, and these approaches have not been substantially effective for BCC. Photodynamic therapy with ALA methylester has been used for individual BCCs and may cause less discomfort, although pain has been reported 45,46 ; the surface preparation used in these studies would be impractical for our patients.…”
Section: Treatment Parametersmentioning
confidence: 99%