Laser light-scattering studies of poly(caprolactone-b-ethylene oxide-b-caprolactone) nanoparticles and their enzymatic biodegradation

Zhao, Yue; Hu, Tianyi; Lv, Ze; Wang, Shenguo; Wu, Chi

doi:10.1002/(sici)1099-0488(19991201)37:23<3288::aid-polb3>3.0.co;2-l

Cited by 31 publications

(37 citation statements)

References 14 publications

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“…The enzymatic hydrolysis of polyester nanoparticles has been investigated previously by laser light scattering [40][41][42], titration [22], and turbidimetric analysis [24]. The intermediate soluble hydrolysis products formed during the hydrolysis of PET nanoparticles by the polyester hydrolase TfCut2 could be reliably determined and quantified by reversed-phase HPLC [13,14,34,35].…”

Section: Discussionmentioning

confidence: 99%

Effect of hydrolysis products on the enzymatic degradation of polyethylene terephthalate nanoparticles by a polyester hydrolase from Thermobifida fusca

Barth

Oeser

Wei

et al. 2015

Biochemical Engineering Journal

180

167

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Section: Discussionmentioning

confidence: 99%

Effect of hydrolysis products on the enzymatic degradation of polyethylene terephthalate nanoparticles by a polyester hydrolase from Thermobifida fusca

Barth

Oeser

Wei

et al. 2015

Biochemical Engineering Journal

180

167

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“…29 Zimm plots yielded molar masses of approximately 1.80 × 10 6 and 2.97 × 10 6 g mol -1 , and the corresponding arm numbers of the micelles, N agg , are 226 for Sam10 and 193 for Sam20 (Table 4).…”

Section: Scheme 2 Preparation Of Micelles By Polymer Linking Reactionmentioning

confidence: 99%

Reversible Addition−Fragmentation Transfer Polymerization in Nanosized Micelles Formed in Situ

2005

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The reversible addition-fragmentation transfer (RAFT) polymerizations of 4-vinylpyridine (4VP) in tetrahydrofuran (THF) and in cyclohexane with RAFT agent, dithiobenzoate-terminated polystyrene (PS-SC(S)Ph), involve one polymerization rate (R p ) 0.083 mol L -1 h -1 ) and two stages of polymerization (R p ) 0.164 and 0.0024 mol L -1 h -1 before and after 5 h), respectively. The polymerization of 4VP and divinylbenzene (less than 10% relative to 4VP) in THF led to gelation, but the polymerization in cyclohexane displayed clear solution consistently throughout polymerization, and kinetic studies showed sudden decrease of polymerization rate and sharp increase of molecular weight at around 5 h. Polymerization was followed by gel permeation chromatography (GPC) and the combination of GPC and multiangle laser light scattering (MALLS). The results show the formation of micelles with PS as shell and poly(PVP-co-DVB) as core by microphase separation; the micelles' size increased fast around 5 h polymerization, and then the micelles grew slowly with progress of polymerization. A series of experiments were made to look for reasons for the decrease of polymerization rate at around 5 h of polymerization, and the possible reasons are the restriction of diffusion and higher concentration of dithiobenzoate groups in the cores of micelles. The effects of molecular weight of RAFT agent and the content of DVB in the mixture of 4VP and DVB on the polymerization and the formation of micelles were also investigated. 1 H NMR, dynamic and static light scattering (DLS, SLS), transmission electron micrograph (TEM), and atomic force microscopy (AFM) were used to characterize the micelles, and the micelles with less than 50 nm in diameter and narrow size distribution were obtained. Thus, an efficient synthetic method of stable micelles was developed in comparison with the self-assembling of block and graft polymers in selective solvents, and one advantage of this method is that the polymerization, micellization, and cross-linking reactions occur in one pot, forming stable, narrow micelles with functional cores.

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“…A combination of the decrease of the scattered light intensity and the constant size of the remaining particles reveals that not all the particles were simultaneously degraded. [9,32] The degradation is a random ''one-by-one'' process. The degradation of individual particles was too fast to be followed by our present LLS setup.…”

Section: Laser Light Scatteringmentioning

confidence: 99%

Formation and Degradation of Poly(D,L‐lactide) Nanoparticles and Their Potential Application as Controllable Releasing Devices

Zhao

et al. 2004

Macromolecular Bioscience

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In the presence of surfactant, water-insoluble poly(D,L-lactide) (PLA) was dispersed into narrowly distributed nanoparticles stable in water via microphase inversion. The structure and degradation of such formed nanoparticles were investigated by a combination of static and dynamic laser light scattering. Our results revealed that the degradation rate increased with the temperature and pH so that the degradation could be regulated from minutes to days. Using anionic sodium dodecyl sulfate (SDS) as stabilizer resulted in a slower degradation than using cationic hexadecyltrimethylammonium bromide (HTAB). The phthalocyanine chromophores (PC) could be encapsulated inside these PLA nanoparticles. The degradation of individual PLA nanoparticles led to a controllable releasing of PC. The absorption and fluorescence studies revealed a correlation between the degradation and the releasing of PC. Our results showed that a higher PC/PLA ratio could lead to a faster degradation.

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Laser light-scattering studies of poly(caprolactone-b-ethylene oxide-b-caprolactone) nanoparticles and their enzymatic biodegradation

Cited by 31 publications

References 14 publications

Effect of hydrolysis products on the enzymatic degradation of polyethylene terephthalate nanoparticles by a polyester hydrolase from Thermobifida fusca

Effect of hydrolysis products on the enzymatic degradation of polyethylene terephthalate nanoparticles by a polyester hydrolase from Thermobifida fusca

Reversible Addition−Fragmentation Transfer Polymerization in Nanosized Micelles Formed in Situ

Formation and Degradation of Poly(D,L‐lactide) Nanoparticles and Their Potential Application as Controllable Releasing Devices

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