Laser irradiation as a potential pathogenetic method for immunocorrection in rheumatoid arthritis

Timofeyev, Valeriy; Poryadin, G. V.; Goloviznin, Mark

doi:10.1016/s0928-4680(00)00059-6

Cited by 11 publications

(5 citation statements)

References 4 publications

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“…ILIB has been applied to many diseases, for instance, arthritis [5][6][7], fibromyalgia [8], hepatic disease [9], postpartum mastitis [10], diabetes mellitus [11][12][13], some systemic dys-metabolism [14,15], and regional cerebral hypoperfusion [4,16], as its properties of improving oxygen supply and hence amplifying microcirculation.…”

Section: Discussionmentioning

confidence: 99%

Effects of Intravascular Laser Irradiation of Blood on Cognitive Function in a Stroke Survivor with Hyperhomocysteinemia: Dual Recuperations in Thalamus and Serum Homocysteine

Chang

2019

BJSTR

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Section: Discussionmentioning

confidence: 99%

Effects of Intravascular Laser Irradiation of Blood on Cognitive Function in a Stroke Survivor with Hyperhomocysteinemia: Dual Recuperations in Thalamus and Serum Homocysteine

Chang

2019

BJSTR

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“…Their study does not answer the question whether ILIB-therapy has a prolonged disease-modifying action. Further long-term studies of its clinical efficiency and mechanism of action are necessary to determine the place and significance of ILIB in rheumatology 93 .…”

Section: Radiosynovectomy In Rheumatoidmentioning

confidence: 99%

Untitled

2011

IJPSR

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Rheumatoid arthritis (RA) is an aggressive disease that needs to be treated effectively if subsequent deformity and disability are to be reduced. A recent advance in the management of RA is the use of biological agents which block certain key molecules involved in the pathogenesis of the illness. They include tumor necrosis factor (TNF-) -blocking agents, Anti-Interleukin-1receptor (IL-1) antagonist, anti-CD-20 agents, CTLA-4 Ig, anti IL-6 etc. These newer agents proved to be useful for alleviating symptoms and slowing the disease progression in the patients with RA who have failed to respond to conventional disease modifying anti-rheumatic drugs (DMARDs). DMARDs are nonspecific immunomodulators, each of which has substantial drawbacks in terms of effectiveness or adverse effects (AEs). The development of biologic agents has provided more effective therapeutic options. The terms biologic therapies and biologics have emerged to describe agents with biologic properties, including monoclonal antibodies and soluble cytokine receptors etc. The advent of effective biological agents has certainly been a major advance in the treatment of inflammatory arthritis, heralding a new era for rheumatology. In this review the focus is only on pathophysiology of the disease process as well as the recent advances with Biological response modifiers (BRMs) and its impact on current clinical practice in the treatment of RA.

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“…6 However, these treatments have many side effects and complications requiring the development of new treatment modalities. 7 Low-level laser therapy (LLLT) was found to have analgesic and bio-modulative effects, 8 so it has been widely used in dental practice for the management of dentine hypersensitivity, soft tissue disorders, musculoskeletal pain, and for stimulating bone regeneration. It has also been applied as a conservative treatment modality enhancing function and reducing patients' complaints.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Low-level Laser Photobiomodulation on Adjuvant Induced Temporomandibular Joint Arthritis in A Rat Model

2023

Mansoura Journal of Dentistry

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Objective: To test the efficacy of low-level laser therapy (LLLT) to alleviate temporomandibular TMJ induced arthritis in rats. Materials and methods: Rats were randomly allocated to three groups: group I (sham control), group II (arthritis) where animals were subjected to arthritis induction using complete Freund's adjuvant followed by LLLT (0 j/cm 2 ), and group III (LLLT) where animals were subjected to arthritis induction followed by LLLT (38 j/cm 2 ). One and three weeks after treatment onset, rats were euthanized and specimens were subjected to histological, histomorphometric, and histochemical analysis. Results: The sham group showed normal histology. The arthritic group showed severe changes with surface irregularity, loss of condylar zones, hypocellularity, and bone resorption. The articular disc was significantly increased in thickness (P=0.0005), while the condylar cartilage was atrophied (P<0.0001). LLLT treatment caused significant enhancement of disc (P<0.0001) and cartilage thickness (P=0.0001) compared to the arthritic group after three weeks. The histological structure of TMJs appeared more regularly arranged than the arthritis group with better results after three weeks, where articular surfaces showed uniform outlines, chondrocytes were well arranged, less osteochondral detachment was detected, and subchondral bone showed arranged trabeculae. However, LLLT did not restore complete normal architecture as compared to the sham group. Conclusions: LLLT can significantly promote the regeneration and healing of arthritic TMJs. However, longer follow-up periods or different laser doses may be recommended to restore normal tissue architecture.

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Laser irradiation as a potential pathogenetic method for immunocorrection in rheumatoid arthritis

Cited by 11 publications

References 4 publications

Effects of Intravascular Laser Irradiation of Blood on Cognitive Function in a Stroke Survivor with Hyperhomocysteinemia: Dual Recuperations in Thalamus and Serum Homocysteine

Effects of Intravascular Laser Irradiation of Blood on Cognitive Function in a Stroke Survivor with Hyperhomocysteinemia: Dual Recuperations in Thalamus and Serum Homocysteine

Untitled

Therapeutic Potential of Low-level Laser Photobiomodulation on Adjuvant Induced Temporomandibular Joint Arthritis in A Rat Model

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