Laser Interstitial Thermal Therapy for Posterior Fossa Lesions: An Initial Experience

Borghei-Razavi, Hamid; Koech, Hilary; Sharma, Mayur; Krivosheya, Daria; Lee, Bryan S.; Barnett, Gene H.; Mohammadi, Alireza

doi:10.1016/j.wneu.2018.05.217

Cited by 34 publications

(17 citation statements)

References 24 publications

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“…A total of 150 patients with a mean age of 56.47 years had undergone LITT for posterior fossa tumors between 2014 and 2021 ( Table 1 ) [ 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 23 , 24 , 25 , 26 ]. Of these patients, 76.1% were female and 23.9% were male.…”

Section: Resultsmentioning

confidence: 99%

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Laser Interstitial Thermal Therapy for Posterior Fossa Lesions: A Systematic Review and Analysis of Multi-Institutional Outcomes

Sabahi

Bordes

Najera

et al. 2022

Cancers

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Background: Laser interstitial thermal therapy (LITT) has emerged as a treatment option for deep-seated primary and metastatic brain lesions; however, hardly any data exist regarding LITT for lesions of the posterior fossa. Methods: A quantitative systematic review was performed. Article selection was performed by searching MEDLINE (using PubMed), Scopus, and Cochrane electronic bibliographic databases. Inclusion criteria were studies assessing LITT on posterior fossa tumors. Results: 16 studies comprising 150 patients (76.1% female) with a mean age of 56.47 years between 2014 and 2021 were systematically reviewed for treatment outcomes and efficacy. Morbidity and mortality data could be extracted for 131 of the 150 patients. Death attributed to treatment failure, disease progression, recurrence, or postoperative complications occurred in 6.87% (9/131) of the pooled sample. Procedure-related complications, usually including new neurologic deficits, occurred in approximately 14.5% (19/131) of the pooled sample. Neurologic deficits improved with time in most cases, and 78.6% (103/131) of the pooled sample experienced no complications and progression-free survival at the time of last follow-up. Conclusions: LITT for lesions of the posterior fossa continues to show promising data. Future clinical cohort studies are required to further direct treatment recommendations.

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Section: Resultsmentioning

confidence: 99%

“…Various techniques, such as OsiriX MD (Pixmeo SARL, Geneva, Switzerland) [ 11 , 12 ] and iplan workstation (BrainLab, Munich, Germany) [ 13 , 14 , 15 ], were used in different studies to provide tumor dimensions and volumetric analyses.…”

Section: Methodsmentioning

confidence: 99%

Laser Interstitial Thermal Therapy for Posterior Fossa Lesions: A Systematic Review and Analysis of Multi-Institutional Outcomes

Sabahi

Bordes

Najera

et al. 2022

Cancers

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“…For lesions consistent with RN, LITT is commonly employed for patients that may not be good surgical candidates (e.g. deep-seated lesion location, advanced patient age, poor patient functional status) and have failed to respond to conservative treatments with corticosteroids [54,70,96,97]. Reported outcome data for these patients are promising with local control rates reaching 75% recurrence free [54].…”

Section: Brain Metastasis and Rnmentioning

confidence: 99%

“…Nevertheless, both studies highlight the need of clinical trials to evaluate the role of LITT in HGGs. LITT has been also employed for low grade gliomas (LGGs) with promising results [63,97,119]. However, the lack of long-term follow-up data and controlled clinical trials precludes any assumptions regarding the role of LITT in this subset of patients.…”

Section: Gliomasmentioning

confidence: 99%

Hyperthermia treatment advances for brain tumors

Skandalakis

Rivera

Rizea

et al. 2020

International Journal of Hyperthermia

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Hyperthermia therapy (HT) of cancer is a well-known treatment approach. With the advent of new technologies, HT approaches are now important for the treatment of brain tumors. We review current clinical applications of HT in neuro-oncology and ongoing preclinical research aiming to advance HT approaches to clinical practice. Laser interstitial thermal therapy (LITT) is currently the most widely utilized thermal ablation approach in clinical practice mainly for the treatment of recurrent or deepseated tumors in the brain. Magnetic hyperthermia therapy (MHT), which relies on the use of magnetic nanoparticles (MNPs) and alternating magnetic fields (AMFs), is a new quite promising HT treatment approach for brain tumors. Initial MHT clinical studies in combination with fractionated radiation therapy (RT) in patients have been completed in Europe with encouraging results. Another combination treatment with HT that warrants further investigation is immunotherapy. HT approaches for brain tumors will continue to a play an important role in neuro-oncology.

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“… 18 Another study of 8 posterior fossa lesions, including 2 RNs, 3 BMs, and 3 primary brain tumors (2 pilocytic astrocytomas and 1 GBM) found that 1 needed open resection 7.7 months after LITT and 2 had disease progression (GBM and one BM); all other lesions remained stable or diminished at median follow-up of 14.8 months. 19 It appears that posterior fossa lesions can be treated with LITT, although their location should be taken into account as significant lesion volume expansion can be expected after treatment.…”

Section: Treatment Outcomesmentioning

confidence: 99%

Laser interstitial thermal therapy

Holste

Orringer

2019

Neuro-Oncology Advances

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Background Laser interstitial thermal therapy (LITT) is becoming an increasingly popular technique for the treatment of brain lesions. More minimally invasive that open craniotomy for lesion resection, LITT may be more appropriate for lesions that are harder to access through an open approach, deeper lesions, and for patients who may not tolerate open surgery. Methods A search of the current primary literature on LITT for brain lesions on PubMed was performed. These studies were reviewed and updates on the radiological, pathological, and long-term outcomes after LITT for brain metastases, primary brain tumors, and radiation necrosis as well as common complications are included. Results Larger extent of ablation and LITT as frontline treatment were potential predictors of favorable progression-free and overall survival for primary brain tumors. In brain metastases, larger extent of ablation was more significantly associated with survival benefit, whereas tumor size was a possible predictor. The most common complications after LITT are transient and permanent weakness, cerebral edema, hemorrhage, seizures, and hyponatremia. Conclusions Although the current literature is limited by small sample sizes and primarily retrospective studies, LITT is a safe and effective treatment for brain lesions in the correct patient population.

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Laser Interstitial Thermal Therapy for Posterior Fossa Lesions: An Initial Experience

Cited by 34 publications

References 24 publications

Laser Interstitial Thermal Therapy for Posterior Fossa Lesions: A Systematic Review and Analysis of Multi-Institutional Outcomes

Laser Interstitial Thermal Therapy for Posterior Fossa Lesions: A Systematic Review and Analysis of Multi-Institutional Outcomes

Hyperthermia treatment advances for brain tumors

Laser interstitial thermal therapy

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