The essence of laser beam is a directed high-intensity energy flow. Laser-material interaction features highly sophisticated microscopic mechanisms and a variety of macroscopic effects. This chapter discusses laser-induced macroscopic thermal and mechanical effects on targets from energy sediment with laser irradiance lying in the "material damage range" (10°W/cm 2 < I L < 10 13 W/cm 2 ). As laser power density decreases in this range, a large spectrum of macroscopic thermal and mechanical phenomena, such as impulse coupling, laser-induced shock wave and target spallation, melting and vaporization, thermal softening, thermal stress, prevail. These phenomena are closely related to intense shock or elasoplastic characteristics of materials and structures.