Laser-induced plasma on a metal surface for ionization of organic compounds at atmospheric pressure

Pento, A. V.; Bukharina, A. B.; Никифоров, С. М.; Simanovsky, Yaroslav O.; Sartakov, Boris G.; Ablizen, Roman S.; Fabelinsky, V. I.; Смирнов, В. В.; Grechnikov, A. A.

doi:10.1016/j.ijms.2020.116498

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…1 ). The description of the setup has been given in details in 35 , 39 . It differs from commercial devices in (i) the way VOCs are ionized, (ii) the absence of a hot capillary at the inlet of the device, and (iii) an appliance for introducing VOCs from a urine sample in the as-is state at room temperature.…”

Section: Methodsmentioning

confidence: 99%

“…This requires the use of a mass spectrometer operating without sample preparation and recording VOCs in air at room temperature. The main distinguishing feature of the device is the method developed by the authors for ionization of VOCs by vacuum ultraviolet radiation, emitted by the laser plasma generated on a metal target (atmospheric pressure laser plasma ionization, APLPI) 34 , 35 . To identify individuals with transplanted tumour tissue, we used a probabilistic assessment method based on a limited amount of information obtained from VOC analysis.…”

Section: Introductionmentioning

confidence: 99%

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Changes in the urine volatile metabolome throughout growth of transplanted hepatocarcinoma

Kochevalina

Bukharina

Trunov

et al. 2022

Sci Rep

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Trained detection dogs distinguish between urine samples from healthy organisms and organisms with malignant tumors, suggesting that the volatile urine metabolome contains information about tumor progression. The aim of this study was to determine whether the stage of tumor growth affects the chemical differences in the urine of mice and to what extent the "olfactory image of disease" perceived by dogs coincides with the "image of disease" recorded by the mass spectrometer. We used a novel laser ionization mass spectrometry method and propose a mass spectrometric analysis without detailed interpretation of the spectrum of volatile metabolomes in urine. The mass spectrometer we use works without sample preparation and registers volatile organic compounds in air at room temperature without changing the pH of the sample, i.e. under conditions similar to those in which dogs solve the same problem. The experimental cancer models were male BDF-f1 hybrid mice transplanted with hepatocarcinoma tissue, and similar mice transplanted with healthy liver tissue were used as controls. Our data show that both dogs and our proposed laser mass spectrometry method are able to detect both the entire spectrum of volatile organic compounds associated with the disease and minor changes in this spectrum during its course.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in the urine volatile metabolome throughout growth of transplanted hepatocarcinoma

Kochevalina

Bukharina

Trunov

et al. 2022

Sci Rep

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“…Passively Q-switched microchip laser is an effective method to achieve high repetition rate, narrow pulse width and high-power pulse sequence output because of its low-cost, simplicity and robustness [1][2][3]. It has broad application prospects in many fields such as laser ranging, laser imaging and environmental monitoring and pumping nonlinear optical frequency converters [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Study on pulse jitter of passively Q-switched Nd:YAG/Cr:YAG microchip laser

Qiao

Li²,

Zhang³

et al. 2022

Advanced Lasers, High-Power Lasers, and Applications XIII

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Based on the rate equation of passively Q-switching, the effects of pump rate on the pulse timing jitter was simulated. The evolution of pulse jitter versus initial transmittance of the saturated absorber and pump power were experimentally investigated using different Nd:YAG/Cr:YAG bonded crystals. By adopting reasonable parameters, it was proved that the pulse jitter of passively Q-switching could be controlled within hundreds of nanoseconds. If an actively Q-switched laser was used as the seed laser for a passively Q-switched microchip laser, the pulse jitter could be reduced down to ~5 ns, and the output characteristics of the passively Q-switched laser with seed injection were discussed.

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Near-diffraction-limit 1-kHz sub-nanosecond diode-end-pumped Nd:YAG laser amplifier via self-compensating spherical aberration

Qiao¹,

Zhong²,

Li³

et al. 2023

Optics & Laser Technology

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Laser-induced plasma on a metal surface for ionization of organic compounds at atmospheric pressure

Cited by 8 publications

References 32 publications

Changes in the urine volatile metabolome throughout growth of transplanted hepatocarcinoma

Changes in the urine volatile metabolome throughout growth of transplanted hepatocarcinoma

Study on pulse jitter of passively Q-switched Nd:YAG/Cr:YAG microchip laser

Near-diffraction-limit 1-kHz sub-nanosecond diode-end-pumped Nd:YAG laser amplifier via self-compensating spherical aberration

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