Laser‐induced hyperthermia for treatment of granulation tissue growth in rats

Landsberg, Roee; DeRowe, Ari; Katzir, Abraham; Shtabsky, Alexander; Fliss, Dan M.; Gil, Ziv

doi:10.1016/j.otohns.2008.12.004

Cited by 17 publications

(13 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to the papers discussed above, Landsberg et al [56] showed beneficial effects of heat on granulation tissue (GT) formation in the rat. In this study, skin was excised first and GT developed in the wound area.…”

Section: Effects Of Heat On Other Tissuesmentioning

confidence: 95%

Thresholds for thermal damage to normal tissues: An update

Yarmolenko

Moon

Landon

et al. 2011

International Journal of Hyperthermia

583

487

View full text Add to dashboard Cite

The purpose of this review is to summarise a literature survey on thermal thresholds for tissue damage. This review covers published literature for the consecutive years from 2002–2009. The first review on this subject was published in 2003. It included an extensive discussion of how to use thermal dosimetric principles to normalise all time-temperature data histories to a common format. This review utilises those same principles to address sensitivity of a variety of tissues, but with particular emphasis on brain and testis. The review includes new data on tissues that were not included in the original review. Several important observations have come from this review. First, a large proportion of the papers examined for this review were discarded because time–temperature history at the site of thermal damage assessment was not recorded. It is strongly recommended that future research on this subject include such data. Second, very little data is available examining chronic consequences of thermal exposure. On a related point, the time of assessment of damage after exposure is critically important for assessing whether damage is transient or permanent. Additionally, virtually no data are available for repeated thermal exposures which may occur in certain recreational or occupational activities. For purposes of regulatory guidelines, both acute and lasting effects of thermal damage should be considered.

show abstract

Section: Effects Of Heat On Other Tissuesmentioning

confidence: 95%

Thresholds for thermal damage to normal tissues: An update

Yarmolenko

Moon

Landon

et al. 2011

International Journal of Hyperthermia

583

487

View full text Add to dashboard Cite

show abstract

“…Although PTT has been previously reported to successfully treat granulation tissue formation, there is no consensus regarding the optimal temperature for local heating for the treatment of stent-induced granulation tissue formation 11 , 20 , 24 – 26 . Several studies have reported that at 43 to 65 °C can help inhibit tissue hyperplasia but that an increase to 70 °C induced immediate tissue burn 11 , 19 , 25 . In our current study, stent-induced granulation tissue formation in the rat esophagus was effectively treated with AuNP coated SEMS-mediated local heating at 65 °C, which may effectively burn the granulation tissues generated around the stent.…”

Section: Discussionmentioning

confidence: 99%

Photothermal therapy via a gold nanoparticle-coated stent for treating stent-induced granulation tissue formation in the rat esophagus

Cho

Kang

Park

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Minimally invasive therapies using stent technology are currently limited by stent-induced granulation tissue formation adjacent to the stent. The effectiveness of photothermal therapy (PTT) using a gold nanoparticle (AuNP)-coated stent for treating stent-induced granulation tissue formation in the rat esophagus was investigated. All experiments were approved by the animal research committee of our institution. An AuNP-coated, self-expandable metallic stent (SEMS) was produced to conduct PTT under near-infrared laser irradiation. Forty rats were randomly divided into four groups (10 rats each). The animals in group A (non-coated SEMS) and group B (AuNP-coated SEMS with local heating at 65 °C at 4 weeks) were sacrificed 4 weeks after stent placement. The rats in group C (AuNP-coated SEMS with local heating at 65 °C at 4 weeks) and group D (AuNP-coated SEMS with local heating at 65 °C at 4 and 8 weeks) were sacrificed 8 weeks after stent placement. The effectiveness of local heating was assessed by histopathology. All procedures were successful in all of the animals. Seven rats were excluded because of stent migration (n = 2) and death (n = 5). Granulation tissue formation-related variables were significantly higher in group A than in groups B–D (all p < 0.05). Heat-shock protein 70 (HSP70) and TUNEL expression were significantly lower in group A than in groups B–D (all p < 0.05). Granulation tissue formation-related variables were significantly higher in group C than in groups B and D (all p < 0.05). PTT using AuNP-coated SEMS successfully treated granulation tissue formation after stent placement in the rat esophagus.

show abstract

“…Although PTT has been previously reported to successfully treat granulation tissue formation, there is no consensus regarding the optimal temperature for local heating for the treatment of stent-induced granulation tissue formation. 11,20,[24][25][26] Several studies have reported that at 43 °C to 65 °C can help inhibit tissue hyperplasia but that an increase to 70 °C induced immediate tissue burn. 11,19,25 In our current study, stent-induced granulation tissue formation in the rat esophagus was effectively treated with AuNP coated SEMS-mediated local heating at 65 °C, which may effectively burn the granulation tissues generated around the stent.…”

Section: Discussionmentioning

confidence: 99%

Photothermal Therapy via a Gold Nanoparticle-Coated Stent for Treating Stent-Induced Granulation Tissue Formation in the Rat Esophagus

Cho

Kang

Park

et al. 2020

Preprint

View full text Add to dashboard Cite

Minimally invasive therapies using stent technology are currently limited by stent-induced granulation tissue formation adjacent to the stent. The effectiveness of photothermal therapy (PTT) using a gold nanoparticle (AuNP)-coated stent for treating stent-induced granulation tissue formation in the rat esophagus was investigated. All experiments were approved by the animal research committee of our institution. An AuNP-coated, self-expandable metallic stent (SEMS) was produced to conduct PTT under near-infrared laser irradiation. Forty rats were randomly divided into four groups (10 rats each). The animals in group A (non-coated SEMS) and group B (AuNP-coated SEMS with local heating at 65°C at 4 weeks) were sacrificed 4 weeks after stent placement. The rats in group C (AuNP-coated SEMS with local heating at 65°C at 4 weeks) and group D (AuNP-coated SEMS with local heating at 65°C at 4 and 8 weeks) were sacrificed 8 weeks after stent placement. The effectiveness of local heating was assessed by histopathology. All procedures were successful in all of the animals. Seven rats were excluded because of stent migration (n = 2) and death (n = 5). Granulation tissue formation-related variables were significantly higher in group A than in groups B-D (all p < 0.05). HSP70 and TUNEL expression were significantly lower in group A than in groups B-D (all p < 0.05). Granulation tissue formation-related variables were significantly higher in group C than in groups B and D (all p < 0.05). PTT using AuNP-coated SEMS successfully treated granulation tissue formation after stent placement in the rat esophagus.

show abstract

Laser‐induced hyperthermia for treatment of granulation tissue growth in rats

Cited by 17 publications

References 19 publications

Thresholds for thermal damage to normal tissues: An update

Thresholds for thermal damage to normal tissues: An update

Photothermal therapy via a gold nanoparticle-coated stent for treating stent-induced granulation tissue formation in the rat esophagus

Photothermal Therapy via a Gold Nanoparticle-Coated Stent for Treating Stent-Induced Granulation Tissue Formation in the Rat Esophagus

Contact Info

Product

Resources

About