In recent years, wearable flexible sensors have garnered significant attention for their potential in monitoring human physiological signals. Current research focuses on flexible sensors with a wide linear range, high sensitivity, and excellent reliability. Micronanostructures have been introduced to balance these three features to some extent. Inspired by the micronanostructures of human fingerprints, we propose a fingerprint-like flexible sensor that combines polydimethylsiloxane with a grating structure and laser-induced graphene. This fingerprint-like flexible sensor exhibits several desirable characteristics: a wider linear range (0−180°), faster response time (0.3 s), higher sensitivity (688.5 kPa −1 ), and excellent reliability (>10,000 cycles). These features make fingerprint-like flexible sensors particularly suitable for detecting various human physiological signals, including finger flexion, elbow flexion, finger pressure, and pulse. Therefore, there is considerable potential for integrating multiple fingerprint-like sensors into human physiological signal monitoring applications. This approach offers a promising direction for the future development of wearable flexible sensors.